Kimura's disease (KD) is a chronic inflammatory disorder characterized by tumours in the head and neck region, enlarged lymph nodes, increased eosinophil counts andhigh serum IgE. Mast cells are known to play central role IgE-mediated allergic diseases through release of mediators like IL-4, IL-5 chemokines. We hypothesized that mast may pathogenesis KD regulating eosinophilic infiltration IgE synthesis.In order investigate KD, we examined expression cytokines/chemokines lesions KD.We number...

This study implemented a randomized crossover design to evaluate the efficacy and safety of switching from insulin glargine (IGlar) degludec (IDeg) in 18 children (11 males, 7 females; age 11.0 ± 0.5 years) with type 1 diabetes. All subjects had previously used IGlar once daily at bedtime. We compared fasting plasma glucose (FPG) HbA1c levels, frequencies overall nocturnal (2200 h - 0659 h) hypoglycemia, basal dose baseline those measured during 24-week period which or IDeg was administered...

Abstract Background We assessed the association between scanning frequency of flash glucose monitoring (FGM) and continuous (CGM)‐derived glycemic markers in children adolescents with type 1 diabetes. Methods Subjects consisted 85 diabetes using FGM. frequencies FGM‐ CGM‐derived metrics: Time range (TIR) (70‐180 mg/dL), time below (TBR) (<70 above (>180 other – laboratory‐measured HbA1c CGM‐estimated (eA1c) levels subjects. Results The mean number scans was 11.5 ± 3.5 (5–20) times per...

We examined the impact of scanning frequency with flash glucose monitoring on glycemic control in children and adolescents type 1 diabetes.

Abstract Aims/Introduction Coefficient of variation (CV) is an indicator for glucose variability in continuous monitoring (CGM), and the target threshold %CV type 1 diabetes proposed to be ≤36%. This study aimed evaluate clinical significance CV children adolescents with diabetes. Materials Methods Participants included 66 A total 48 participants were treated multiple daily injections insulin, 18 continues subcutaneous insulin infusion, using intermittently scanned CGM. The frequencies CGM...

To analyze changes in the annual incidence of school students with type 2 diabetes detected by urine glucose screening at schools Tokyo Metropolitan Area during 1975-2015.Trend temporal rate were analyzed using a joinpoint regression model and joinpoints. Annual percent change (APC) was calculated for each segmented line regression. Average (AAPC) also whole period analyzed.In total, 301 students, including 64 primary 237 junior high diagnosed diabetes. The overall (per 100 000/year) entire...

We assessed the significance of recommendations from international consensus on continuous glucose monitoring (CGM)-derived metrics in Japanese children and adolescents with type 1 diabetes. Eighty-five patients (age, 13.5 ± 4.7 years) who wore FreeStyle® Libre for a 28-day period were enrolled this study. Seventy-three treated multiple daily injections insulin 12 pump therapy without using sensor-augmented or predictive low-glucose suspend-function pump. evaluated relationship between...

The aim of the study was to compare two continuous glucose monitoring (CGM) systems, intermittently scanned CGM (isCGM) and real-time (rtCGM), determine which system achieved better glycemic control in pediatric patients.We carried out a retrospective cohort children adolescents with type 1 diabetes, compared time range (70-180 mg/dL), below (<70 mg/dL) above (>180 estimated glycated hemoglobin levels between patients on isCGM rtCGM.Of 112 participants, 76 (67.9%) used 36 (32.1%) rtCGM for...

We evaluated the efficacy and safety of switching to insulin degludec (IDeg) from glargine (IGlar) as basal-bolus therapy in young people with type 1 diabetes. The subjects were 36 patients, 21.3±1.0 years age, IGlar had previously been injected once daily 25 patients twice 11. They then switched once-daily injection IDeg. Both fasting plasma glucose (FPG) HbA1c levels decreased significantly 134±3.9 mg/dL 7.9±0.2% at baseline 116±2.2 7.4±0.2% 12 months after starting IDeg (P<0.0001 P≤0.001,...

Rats with hereditary defects in ascorbic acid (AsA) synthesis (ODS rats) subjected to AsA-deficiency for 3 weeks showed reductions of plasma alkaline phosphatase and dry ash weights the tibia, but no body weight alteration. In accordance chemical changes, bone loss decrease formation by AsA deficiency not malnutrition were observed contact microradiographs tibia a tetracycline double labeling technique, respectively. The mechanical properties femora measured three point-bending procedure...

Abstract A case of 80‐year‐old man with a verruciform xanthoma on the right side scrotum was reported. The tumor examined histologically by light and electron microscope. We surveyed literature found 25 Japanese cases 11 foreign in skin. also reviewed pathogenesis location this disease.

&lt;b&gt;&lt;i&gt;Introduction:&lt;/i&gt;&lt;/b&gt; We evaluated the frequencies of various glycemic markers derived from continuous glucose monitoring in Japanese children and adolescents with type 1 diabetes assessed significance hypoglycemia duration. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; enrolled 85 (36 boys 49 girls) who used FreeStyle&lt;sup&gt;®&lt;/sup&gt; Libre present study. Frequencies blood levels as time within target range (TIR; 70–180 mg/dL), below (TBR; &amp;#x3c;70...

We conducted an annual urine glucose screening program at schools, and diagnosed schoolchildren with diabetes early stage of the disease. also identified some cases renal glucosuria (RG), based on positive normal tolerance.During 2000-2015, 3 309 631 participated in program. The rate for first test was approximately 0.1%, whereas repeat it 0.05%. In total 350 were detailed examination. Oral tolerance (OGTT) used to evaluate intolerance.One hundred two (29.7%) diabetes, RG 246 (70.3%)...

There are no study reports to clarify the association between gestational age (GA) or anthropometric values at birth, and plasma cortisol levels in blood of preterm infants birth one month age. This hospital-based retrospective cohort included born &lt;37 weeks’ gestation 2019 2021. First, level GA (birth weight standard deviation score [SDS], length SDS, head circumference SDS) was identified by regression multiple analyses. Second, umbilical cord were compared small-for-gestational (SGA)...

The aim was to investigate the characteristics of abdominal fat distribution in Japanese adolescents with type 2 diabetes mellitus.Eighty-six simple obesity or mellitus treated between 2002 and 2018 were included. subjects classified into group (SO group, n=38) (DM n=23) by matching average age gender ratio. metabolic parameters VFA, SFA, V/S ratio compared groups. Multivariate logistic regression analysis performed identify clinical factors associated mellitus. Linear hemoglobin A1c (HbA1c)...

The first-line pharmacological treatment for patients with maturity-onset diabetes of the young type 1 (MODY1) and 3 (MODY3) are sulfonylureas (SUs) or insulin. However, several reports have suggested possibility using incretin-associated drugs, including dipeptidyl-peptidase-4 (DPP-4) inhibitors, these types MODY. Here we report a case pediatric patient MODY1 who was successfully treated DPP-4 inhibitor, alogliptin. A 13-yr-old Japanese girl initially insulin 5 mo. After diagnosis MODY1,...

(1) 石臼挽きしたそば粉から連続蒸留抽出装置(SDE装置)にて香気濃縮物を得,ガスクロマトグラフィーによる分析を行ない主要成分の含有量を求めた.(2) 更に1の主要成分について官能検査の手法を用いて閾値を求め1の結果とから各物質についてのオーダーユニットを算出した.(3) 2の結果によりnonanal, octanal, hexanal等がオーダーユニットが高くそば粉の香気成分として重要なものであることが分った.(4) 一方,そばを石臼製粉した直後から経時的にその香気濃縮物をガスクロマトグラフィーにて測定した結果nonanalを主成分とするピーク,hexanal, salicylal-dehyde, acetophenoneの製粉後1~2日間に於ける減少が著しかった.(5) 以上の結果より,砕きたてのそば粉の香りを特徴付けるものとしてnonanal, hexanalが重要な香気成分であることが分った.

(1) 石臼挽きしたそば粉から連続蒸留抽出法にて揮発性成分を得,ガスクロマトグラフィーの相対保持時間の測定とGC-MS分析により45物質を同定した。(2) 一方,そばのロール製粉を行ない6区分のそば粉と殼を主体とする区分の合計7区分を得,香りの分布を調べた。一般分析・官能的評価の結果,胚芽や種皮の含有量の多い区分でそばの香りが強いことが分った。(3) さらに(2)の試料について連続蒸留抽出法にて揮発性成分を得,ガスクロマトグラフィーを用いて各区分の比較を行った。その結果,直鎖脂肪族アルコールとsalicylaldehydeを成分とするピークが殼を主体とする区分で特に大きかった。さらに,n-hexanalとn-non-analや2-octanolを成分とするピークがFr.3, Fr.4で最大を示し,その分布傾向はそば粉の匂いの官能的評価の傾向とほぼ一致していた。

We aimed to create percentile-based reference values of the umbilical cord blood insulin-like growth factor-1 (IGF-1) levels in Japanese newborns, as these have not yet been established. A total 259 newborns were classified into four gestational-age-at-birth (GA) groups: extremely preterm (<28 weeks); early (28−33 late (34−36 and term (≥37 weeks). They further subclassified small-for-gestational-age (SGA) or non-SGA. The 10th, 25th, 50th, 75th, 90th percentiles IGF-1 calculated compared...