A5001913534- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Obesity, Physical Activity, Diet
- Fatty Acid Research and Health
- Cancer, Lipids, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Body Composition Measurement Techniques
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Cholesterol and Lipid Metabolism
- Cardiovascular Disease and Adiposity
- Nutrition and Health in Aging
- Peroxisome Proliferator-Activated Receptors
- Hereditary Neurological Disorders
- Lipid metabolism and biosynthesis
- Peripheral Neuropathies and Disorders
- Infectious Diseases and Tuberculosis
- Respiratory and Cough-Related Research
- Food Allergy and Anaphylaxis Research
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Lipid metabolism and disorders
Saiseikai Wakakusa Hospital
2019-2022
Kanagawa Institute of Technology
2022
Nihon University
2006-2016
Tokyo Metropolitan Hiroo Hospital
1996-2007
Beijing Children’s Hospital
2003
Chubu Rosai Hospital
1993
Nagoya Municipal Industrial Research Institute
1990
In adults, visceral fat accumulation is an important indicator for cardiovascular disease risk. This relationship not fully understood in children. To determine the best predictor of risk factors among anthropometric indices such as body mass index (BMI), percent (%Fat), waist-to-hip ratio (WHR), waist circumference, and waist-to-height (W/Ht ratio) Japanese schoolchildren. study included 880 children (447 boys 433 girls), 9-13y age. Dependent variables were total cholesterol (TC),...
In obesity, fatty acid composition is altered with reduced docosahexaenoic (DHA) levels. Desaturating enzymes, stearoyl-CoA desaturase (SCD), delta-6 (D6D) and delta-5 (D5D) modulate are thus associated the development of metabolic syndrome. The aim this study was to identify relationships among DHA content, indices components syndrome in childhood obesity.Thirty-two obese children (27 male, 5 female) aged 12.0±2.6 years (mean±SD), a relative body weight greater than 120% standard for sex,...
In 2001, WHO developed a pole for the administration of praziquantel without use weighing scales, with encouraging results in African populations. present study, was tested on height/weight data from 9354 individuals 11 non-African countries. more than 98% (95% CI 97.8-98.4) estimated an acceptable dosage (30-60 mg/kg), performance statistically similar to that observed Reproducing form strip paper and including it each container would greatly facilitate drug large-scale interventions.
As obesity has been increasing in China, the present study examined body composition of children to assess their fatness.A total 532 healthy schoolchildren who lived central Beijing were examined. Skinfold thicknesses, hip and waist circumferences, fat percentage measured, as well height weight.The prevalence overweight (Body Mass Index (BMI) >or= 95% for age sex Chinese children) was 27.7% boys 14.2% girls (chi-squared; P = 0.0001). The percentages (BF%), waist/hip ratios skinfold...
Abstract Background: Although there have been many studies on the relationship between obesity and long‐chain polyunsaturated fatty acid (LCPUFA), results their interpretation are controversial, especially in children. Arachidonic (AA), product of n‐6 LCPUFA, is reported to be related insulin resistance. The purpose present paper was investigate LCPUFA profile obese children mechanisms that contribute reduced AA content. Method: An age‐ sex‐matched control study performed. subjects were 59...
Background:Alanine-for-threonine substitution at codon 54 (A54T polymorphism) in the fatty acid-binding protein 2 gene (FABP2) has been associated with hypertriglyceridemia and insulin resistance. Impairment activity of delta 6 5 desaturases is also supposed to be a factor predisposing development resistance syndrome.Aim: We investigated relationship between A54T polymorphism FABP2 impairment long-chain polyunsaturated acid metabolism obese children.Methods: Thirty-two children participated....
Plasma fatty acid composition can change with age, reflecting diet and levels of desaturating enzymes such as stearoyl-CoA desaturase (SCD), delta-6 (D6D) delta-5 (D5D), which contribute to the development insulin resistance. This study analyzed longitudinal changes in Japanese children during early puberty association between indices body fatness resistance.The included 77 (38 boys 39 girls) aged 9.6±0.5 years. Relative weight (RW) waist-to-height ratio (WHtR) were determined. The plasma...
The aim was to investigate the characteristics of abdominal fat distribution in Japanese adolescents with type 2 diabetes mellitus.Eighty-six simple obesity or mellitus treated between 2002 and 2018 were included. subjects classified into group (SO group, n=38) (DM n=23) by matching average age gender ratio. metabolic parameters VFA, SFA, V/S ratio compared groups. Multivariate logistic regression analysis performed identify clinical factors associated mellitus. Linear hemoglobin A1c (HbA1c)...
To investigate the relationship between clustering of metabolic syndrome (MetS) components and non-high-density lipoprotein cholesterol (non-HDL-C) levels in Japanese obese boys.Subjects were 58 boys aged 12.0±2.6 years, which categorized into three subgroups: abdominal obesity, pre-MetS (abdominal obesity＋1 component), MetS obesity＋2 or more components).Sixteen (27.6%) 32 (55.2%) diagnosed as MetS, respectively. The mean non-HDL-C level total subjects was 139.0±36.4 mg/dl that with...
Abstract Background : The aim of the present study was to examine serum lipid profile in obese Chinese children, their and apolipoprotein A‐I (apoA‐I) B (apoB) levels were examined. Methods subjects 153 patients (109 male 44 female) aged 4−16 years with obesity, who attended outpatient clinic Beijing Children's Hospital. Percentage bodyweight (%BW) ([(bodyweight − standard weight)/standard weight]× 100) obtained. Skinfold thickness hip waist circumference measured. body fat (%BF) estimated...
The purpose of this study was to screen for FCHL in children using serum lipid phenotypes. subjects were 1, 190 (599 male, 591 female) who participated a screening and care program life style-related diseases school children. Total cholesterol, high-density lipoprotein cholesterol triglyceride determined, information on the family history parents obtained by questionnaire. Candidates screened following criteria; type IIb hyperlipidemia, IIa hyperlipidemia with positive CHD, or both. We...
We used the denaturing gradient gel electrophoresis (DGGE) method to investigate 120 Japanese patients with familial hypercholesterolemia (FH) for mutations in promoter region and 18 exons their flanking intron sequence of low density lipoprotein (LDL) receptor gene. Fourteen aberrant DGGE patterns were found, underlying characterized by DNA sequencing. Five novel missense (C317S, F382L A410T, L547V, E693K), two nonsense (W512X K790X), four frameshift mutation (355del7, 1246ins5, 1687ins1,...
In order to know whether the changes in indexes of overweight, body mass index (BMI; kg/m2) and percentage overweight (POW) (%), really represent tendency toward obesity, we examined longitudinal individual these indexes, change composition boys during early pubertal period.The subjects were 50 school who lived Shizuoka, Japan. Standing height weight measured, BMI POW obtained. Body fat (BF%), (FM) lean (LBM) estimated by bioelectrical impedance method. The influence predictive variables...
Abstract Background Recent studies demonstrated that low‐density lipoprotein‐tryglyceride (LDL‐TG) may represent another marker of cardiovascular risks. We therefore measured LDL‐TG including the lipoprotein (LDL) subclass distribution and investigated association between profile clustering metabolic syndrome (MetS) components insulin resistance in Japanese children. Methods The study included 237 schoolchildren (boys 115, girls 122). Four subclasses (large, medium, small, very small) was...
It is not easy to make diagnose FCHL in children, since a clear expression of lipoprotein abnormality unlikely and standard criteria have yet been established. We investigated eight cases childhood their families with respect familial history, anthropometric parameters serum levels, explore the characteristics FCHL. To it necessary clarify both family history lipid profiles parents. In this study, two prominent features were suggested; that TG level affected by obesity age, also particular,...