A5079564597- Epilepsy research and treatment
- Infectious Encephalopathies and Encephalitis
- Neuroscience and Neuropharmacology Research
- RNA regulation and disease
- Neuroscience of respiration and sleep
- Polyomavirus and related diseases
- Autoimmune Neurological Disorders and Treatments
- Psychosomatic Disorders and Their Treatments
- Multiple Sclerosis Research Studies
- Pharmacological Effects and Toxicity Studies
- Vaccine Coverage and Hesitancy
- Intravenous Infusion Technology and Safety
- Tuberous Sclerosis Complex Research
- Airway Management and Intubation Techniques
- Ultrasound in Clinical Applications
- Cardiac and Coronary Surgery Techniques
- Genomics and Rare Diseases
- Spinal Hematomas and Complications
- Vascular Malformations Diagnosis and Treatment
- Misinformation and Its Impacts
- Biochemical and Molecular Research
- Peripheral Neuropathies and Disorders
- Patient Safety and Medication Errors
- Intraoperative Neuromonitoring and Anesthetic Effects
- Bone Metabolism and Diseases
Juntendo University Urayasu Hospital
2025
Miyagi Children's Hospital
2022
Juntendo University
2012-2021
Tokyo Metropolitan Institute of Medical Science
2017-2021
Aichi Medical University
2015
Yamagata Prefectural Shinjo Hospital
2002-2013
Koto Hospital
2012
Johns Hopkins University
1996-2009
University of Shizuoka
2002
Niigata University
1998
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sometimes triggers encephalopathy as a serious neurological complication in children. We previously reported the clinico-radiological findings of SARS-CoV-2-associated encephalopathy. The advent SARS-CoV-2 omicron variant led to marked increase pediatric patients with disease 2019 (COVID-19); however, epidemiological changes according emergence have not yet been documented. Therefore, present study investigated differences during...
N-Acetylneuraminate lyase produced by Escherichia coli was purified and crystallized from a genetically engineered strain (E. SF8/pNAL1). The enzyme showed apparent molecular masses of 105,000 Da on gel filtration 35,000 SDS/PAGE, suggesting that the is trimer. optimum pH temperature were found to be 6.5-7.0 80 degrees C respectively. Km values for N-acetylneuraminate N-glycollylneuraminate 3.3 mM inhibited reduction with NaBH4 in presence substrate, indicating belongs Schiff-base-forming...
We have studied the biosynthesis and intracellular transport of tissue-nonspecific alkaline phosphatase (TNSALP) transiently expressed in COS-1 cells. Mutations were introduced into TNSALP to examine effects a single amino acid substitution on activity TNSALP. The cells expressing wild-type exhibited more than 200-fold higher untransfected ones. Pulse-chase experiments showed that was synthesized as 66-kDa endoglucosaminidase H (Endo H)-sensitive form converted EndoH-resistant forms with...
Previous studies have suggested that partial neuromuscular blockade by vecuronium may inhibit the chemoreceptor neural response to hypoxia. Because acetylcholine and its receptors are critically involved in hypoxic neurotransmission of carotid body, we examined whether interferes with nicotinic processes body inhibits The was harvested from anesthetized adult Wister rats. Carotid sinus nerve activity (CSNA) recorded vitro, whereas perfused Krebs solutions equilibrated 5% CO2/air or CO2/N2....
BackgroundIndividuals with Sturge-Weber syndrome (SWS) often expereince intractable epilepsy and cognitive decline. We hypothesized that the extent of leptomeningeal capillary malformation (LCM) may correlate severity neurological impairment due to SWS. tested hypothesis in a cross-sectional study seizure electroencephalographic (EEG) findings retrospective cohort for surgical indications related LCM.MethodsWe enrolled 112 patients classified them according LCM distribution: (1) bilateral,...
Abstract Background We compared knowledge about and attitudes toward epilepsy the issuing of driver's licenses to people with among non‐medical students before after media controversies. Methods The survey was performed in 2012 2014 using a structured questionnaire. Participants were who attended lecture on neurological diseases children. proportion positive answers each question that 2014. In addition, questions regarding according car accidents linked epilepsy. Results More participants...
The characterization of protein components produced from bone tissues with fracture healing was investigated. Weanling rats were sacrificed between 1 and 7 days after the femoral fracture. Protein content in femoral-diaphyseal markedly elevated by healing. Moreover, when cultured for 24 h a serum-free medium, many proteins released into medium. Analysis sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) showed that molecules diaphyseal Especially, molecule approximately 66...
Abstract Although seizures during infancy in patients with tuberous sclerosis complex are common, neonates infrequent. Here, we report the clinical course and electroencephalography (EEG) findings of a neonate associated clinically silent seizures. The patient was girl whom cardiac tumors were detected on fetal ultrasonography. Brain magnetic resonance imaging neonatal period showed subependymal cortical tubers. Routine EEG indicated unexpected ictal changes no noticeable symptoms. Ictal...
We encountered two children with acute encephalopathy associated unique clinical manifestations. Both the patients had status epilepticus at onset and neuroimaging studies revealed marked brain edema bilateral thalamic lesions. Although they were treated steroids immunoglobulin, their outcomes very poor. A thermolabile variant of carnitine palmitoyltransferase II an elevated interleukin-6 level in cerebrospinal fluid observed one patient each. The constellation findings our is apparently not...