Ken Takahashi

ORCID: 0000-0002-9592-4200
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About
Contact & Profiles
Research Areas
  • Cardiovascular Function and Risk Factors
  • Congenital Heart Disease Studies
  • Cardiac Valve Diseases and Treatments
  • Cardiac Imaging and Diagnostics
  • Cardiovascular Issues in Pregnancy
  • Cardiac Structural Anomalies and Repair
  • Cardiovascular Health and Disease Prevention
  • Coronary Artery Anomalies
  • Cardiac Arrhythmias and Treatments
  • Kawasaki Disease and Coronary Complications
  • Heart Rate Variability and Autonomic Control
  • Cardiomyopathy and Myosin Studies
  • Tracheal and airway disorders
  • Cardiovascular Conditions and Treatments
  • Cardiac electrophysiology and arrhythmias
  • Chemotherapy-induced cardiotoxicity and mitigation
  • Cardiovascular Disease and Adiposity
  • Colorectal Cancer Surgical Treatments
  • Infective Endocarditis Diagnosis and Management
  • Cardiac, Anesthesia and Surgical Outcomes
  • Pregnancy and preeclampsia studies
  • Gestational Diabetes Research and Management
  • Metastasis and carcinoma case studies
  • Cardiac pacing and defibrillation studies
  • Pulmonary Hypertension Research and Treatments

Juntendo University
2016-2025

Juntendo University Urayasu Hospital
2022-2025

Kyoto University
2024

Yokosuka Kyosai Hospital
2024

Kitano Hospital
2024

Juntendo University Hospital
2019

Tokyo Women's Medical University Hospital
2019

Japan Organization of Occupational Health and Safety
2013-2018

Musashino Red Cross Hospital
2017

Matsumoto Livestock Hygiene Service Center
2016

To elucidate the histopathological characteristics of myocarditis in acute-phase Kawasaki disease (KD).The examined materials were from 29 autopsied KD patients who died within 40 days following onset. Each heart was divided into three levels: base, middle and apex. At each these levels, myocardium further epicardial, endocardial layers, time-courses changes distribution inflammation analysed. Inflammatory cell infiltration, consisting mainly lobulated leucocytes large mononuclear cells,...

10.1111/j.1365-2559.2012.04332.x article EN Histopathology 2012-05-30

Tricuspid regurgitation in hypoplastic left heart syndrome has an impact on outcome, but its mechanisms remain unclear.Real-time 3-dimensional echocardiography was performed 35 patients with (age, 1 month to 10 years; after first-stage Norwood, 12 superior cavopulmonary shunt, 13 Fontan). From the data set, we marked annulus systole and diastole. At mid systole, location of papillary muscle tip point chordal attachment leaflet. We traced surfaces tricuspid valve leaflets measured volume...

10.1161/circulationaha.108.809566 article EN Circulation 2009-09-09

The mitral inflow spectral is expressed as two separate waves: early diastolic trans-mitral flow velocity (E) and late (A) waves. When the heart rate (HR) increases time diminishes, pattern changes from EA-separation to EA-fusion. E wave provides information about preload function. Tissue Doppler imaging (TDI) non-invasive intraventricular pressure gradient (IVPG) based on color-M-mode echocardiography are techniques established in recent years with good repeatability cardiac function...

10.3389/fvets.2025.1507817 article EN cc-by Frontiers in Veterinary Science 2025-02-19

Evaluation of diastolic function is a pivotal challenge due to limitations the conventional echocardiography, especially when heart rate rapid as in rats. Currently, by using color M-mode echocardiography (CMME), intraventricular pressure difference (IVPD) and gradient (IVPG) early diastole can be generated are available echocardiographic indices. These indices expected useful for diagnosis failure (HF), dysfunction. There have not been any studies demonstrating changes IVPD IVPG response...

10.3390/diagnostics11081403 article EN cc-by Diagnostics 2021-08-03

Background Uremic cardiomyopathy (UC), the main cause of death in progressive chronic kidney disease (CKD), is characterized by diastolic dysfunction. Intraventricular pressure gradients (IVPG) derived from color m-mode echocardiography (CMME) and two-dimensional speckle tracking (2DSTE) were established as novel echocardiographic approaches for non-invasive repeatable assessment cardiac function. Previously, salvianolic acid B (Sal B) showed potential to alleviate concentric LV hypertrophy...

10.3389/fvets.2022.905759 article EN cc-by Frontiers in Veterinary Science 2022-06-16

Abstract Background Although atezolizumab plus bevacizumab (Atezo/Bev) therapy has been used as the preferred first-line treatment for advanced hepatocellular carcinoma (HCC), up to 26% of patients do not achieve disease control, suggesting alternative treatments might be more beneficial such patients. We investigated key predictors refractoriness Atezo/Bev therapy, particularly in setting. Methods retrospectively analyzed 302 with HCC who received between October 2020 and September 2022...

10.1007/s00535-024-02150-7 article EN cc-by Journal of Gastroenterology 2024-09-18

Background:Left ventricular (LV) dysfunction in patients with repaired tetralogy of Fallot (rTOF) is an important risk factor for adverse outcomes. The aim this study was to assess the details and time course such LV using layer-specific strain analysis by echocardiography.

10.1253/circj.cj-16-1162 article EN Circulation Journal 2017-01-01

The present study aimed to provide a complete conventional echocardiographic protocol in adult male Shiba goats by using two-dimensional, M-mode, Pulsed Wave Doppler, and tissue Doppler imaging (TDI) echocardiography, concomitantly xylazine-induced alteration of cardiac functions highly sensitive species. For this purpose, 12 were included echocardiography from the standard right left parasternal views was carried report data goats, also before after xylazine (Pre-Xyl Post-Xyl)...

10.3390/ani10122320 article EN cc-by Animals 2020-12-07

Background Heart rate variability (HRV) is believed to possess the potential for disease detection. However, early identification of heart remains challenging, as HRV analysis in dogs primarily reflects advanced stages disease. Hypothesis/objective The aim this study compare 24-h with sleep assess utility analysis. Animals Thirty healthy no echocardiographic abnormalities were included study, comprising 23 females and 7 males ranging age from 2 months 8 years (mean [standard deviation], 1.4...

10.3389/fvets.2024.1386425 article EN cc-by Frontiers in Veterinary Science 2024-04-11

This study analyzed the change in liver fibrosis markers after Fontan operation and investigated their clinical usefulness as an index of congestive fibrosis.The enrolled 24 patients who underwent between January 1994 December 2008. We subdivided postoperative period into four intervals then compared hepatological during each. Eighteen cardiac catheterization correlation inferior vena cava (IVC) pressure was analyzed.The mean age 138.6 months interval examination 97.8 months. Type IV...

10.1111/j.1442-200x.2011.03497.x article EN Pediatrics International 2011-11-01

Anthracycline cardiotoxicity affects clinical outcomes, and its early detection using methods that rely on conventional echocardiography, such as left ventricular ejection fraction (LVEF) is difficult. This study aimed to evaluate the characteristics differences in cardiac dysfunction among childhood cancer survivors 3 age groups layer-specific strain analysis a wide range.

10.1253/circj.cj-17-0874 article EN Circulation Journal 2017-11-28

Restrictions on the conventional evaluation of diastolic function have been recognized, especially under various loading conditions. Recently, new noninvasive ventricular vortex indexes introduced and are expected to reflect cardiac function. Physiologically, there is a hypothesis that intraventricular pressure difference (IVPD) related formation vortexes. IVPD were simultaneously measured, relationship between two was investigated. To verify possibility vorticity as an index relaxation,...

10.1152/ajpheart.00686.2018 article EN AJP Heart and Circulatory Physiology 2019-02-08

Subclinical diastolic dysfunction in patients with Type 1 diabetes mellitus (T1DM) caused by myocardial injury due to diabetic cardiomyopathy leads a high risk of death and heart failure. This extends not only the left ventricle (LV) but also atrium (LA). However, LA function children young adults T1DM has been extensively studied.Therefore, aim this study was assess pediatric adult using strain analysis echocardiography.Fifty-three (median age: 23 [range: 5-41] years) T1DM.We divided into...

10.1111/pedi.13141 article EN Pediatric Diabetes 2020-10-23
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