A5015605161- Cardiovascular Conditions and Treatments
- Cardiovascular Function and Risk Factors
- Crystallization and Solubility Studies
- Congenital Heart Disease Studies
- X-ray Diffraction in Crystallography
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Cardiac Imaging and Diagnostics
- Hemodynamic Monitoring and Therapy
- Cardiac Arrhythmias and Treatments
- Heart Rate Variability and Autonomic Control
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Silk-based biomaterials and applications
- Cardiac and Coronary Surgery Techniques
- Bone Tissue Engineering Materials
- Cardiac, Anesthesia and Surgical Outcomes
- Pulmonary Hypertension Research and Treatments
- Mechanical Circulatory Support Devices
- Non-Invasive Vital Sign Monitoring
- Asthma and respiratory diseases
- Liver Disease and Transplantation
- Mast cells and histamine
- Mesenchymal stem cell research
- Cardiovascular Effects of Exercise
Tokyo University of Agriculture and Technology
2016-2025
University of Guelph
2024
Zen-Noh (Japan)
2024
Osaka Medical and Pharmaceutical University
2021
E Ink (South Korea)
2019
Azabu University
2015
Effective bladder reconstruction remains a significant challenge in urology, particularly for conditions requiring partial or complete replacement. In this study, the efficacy is evaluated of two types scaffolds, silk fibroin (SF) and adipose-derived stem cells (ADSCs-SF), promoting regeneration their associated outcomes. A rat model was used to compare surgical outcomes morphological recovery tissues implanted with SF ADSCs-SF scaffolds. Post-operative recovery, including voiding ability...
A 2-month-old Shiba Inu was presented to an emergency veterinary clinic with decreased activity and diagnosed pulmonary hypertension secondary a ventricular septal defect. The dog referred the TUAT Veterinary Medical Center for further evaluation. During treatment, diverticulum incidentally identified at apex of left ventricle. While caused no clinical symptoms, cardiac synchronous computed tomography (CT) scan performed accurately assess its anatomical location size. This case highlights...
The mitral inflow spectral is expressed as two separate waves: early diastolic trans-mitral flow velocity (E) and late (A) waves. When the heart rate (HR) increases time diminishes, pattern changes from EA-separation to EA-fusion. E wave provides information about preload function. Tissue Doppler imaging (TDI) non-invasive intraventricular pressure gradient (IVPG) based on color-M-mode echocardiography are techniques established in recent years with good repeatability cardiac function...
Tumors originating from the uterine tube are exceedingly rare in dogs, with limited clinical and therapeutic data available. This report illustrates a case of adenoma one-year-and-two-month-old intact female Pomeranian presented severe abdominal distension. Diagnostic imaging revealed large mass compressing left kidney, suspected to originate reproductive organs. Surgical excision mass, accompanied by ovariohysterectomy, was performed without complications. The tumor, measuring 30 cm...
Evaluation of diastolic function is a pivotal challenge due to limitations the conventional echocardiography, especially when heart rate rapid as in rats. Currently, by using color M-mode echocardiography (CMME), intraventricular pressure difference (IVPD) and gradient (IVPG) early diastole can be generated are available echocardiographic indices. These indices expected useful for diagnosis failure (HF), dysfunction. There have not been any studies demonstrating changes IVPD IVPG response...
Animal-derived xenogeneic biomaterials utilized in different surgeries are promising for various applications tissue engineering. However, decellularization is necessary to attain a bioactive extracellular matrix (ECM) that can be safely transplanted. The main objective of the present study assess structural integrity, biocompatibility, and potential use acellular engineering applications. Hence, bovine pericardium (BP), porcine (PP), tunica vaginalis (PTV) were decellularized using Trypsin,...
Myocardial infarctions remain a leading cause of global deaths. Developing novel drugs to target cardiac remodeling after myocardial injury is challenging. There an increasing interest in exploring natural cardioprotective agents and non-invasive tools like intraventricular pressure gradients (IVPG) heart rate variability (HRV) analysis infarctions. Trehalose (TRE), disaccharide, shows promise treating atherosclerosis, infarction, neurodegenerative disorders.The objective this study was...
Background Heart rate variability (HRV) is believed to possess the potential for disease detection. However, early identification of heart remains challenging, as HRV analysis in dogs primarily reflects advanced stages disease. Hypothesis/objective The aim this study compare 24-h with sleep assess utility analysis. Animals Thirty healthy no echocardiographic abnormalities were included study, comprising 23 females and 7 males ranging age from 2 months 8 years (mean [standard deviation], 1.4...
Restrictions on the conventional evaluation of diastolic function have been recognized, especially under various loading conditions. Recently, new noninvasive ventricular vortex indexes introduced and are expected to reflect cardiac function. Physiologically, there is a hypothesis that intraventricular pressure difference (IVPD) related formation vortexes. IVPD were simultaneously measured, relationship between two was investigated. To verify possibility vorticity as an index relaxation,...
MMVD, the most common cause of CHF in dogs, is a chronic disease with variable clinical signs, some patients remaining asymptomatic while others develop CHF. Here, we aimed to evaluate serum proteins by proteomic analysis dogs at different stages due and proteome behaviors after conventional treatment. A total 32 were divided equally into four groups-stage (healthy/controls), stage B2 (asymptomatic), C D (symptomatic)-according ACVIM consensus. Serum proteomes evaluated using LC/MS-based...
Patch grafts are widely used in various kind of vascular surgeries such as detect repair or dilation stenosis. Expanded polytetrafluoroethylene (ePTFE) patches flexible and handle well, but have shown problems with calcification they non-bioabsorbable therefore permanently remain the body. It is important to develop an alternative biocompatible patch. Silk fibroin (SF) was developed a material, it lacks elasticity required for surgery Polyurethane (PU) also well-known elastomer so this study...
Pulmonary hypertension (PH) is a disease with poor prognosis, and it characterized by the progressive elevation of pulmonary vascular resistance pressure. Various factors are associated pathology PH, including AMP‑activated protein kinase (AMPK) deficiency. The present study aimed to evaluate therapeutic effect metformin, an AMPK activator, in monocrotaline (MCT)‑induced PH rat model. Rats were randomly divided into following three groups: i) Saline‑injected group (sham group);...
Mitral valve regurgitation is a common canine heart disease. Transcatheter Edge-to-Edge Repair (TEER) transcatheter, edge-to-edge mitral repair device that uses hybrid approach. No detailed information has been published on the hemodynamic effect of TEER cardiac function. The aim this report to provide longitudinal observation functional changes observed after implantation in normal dogs using traditional, two-dimensional speckle tracking, and color M-mode echocardiographic methods. In...
Abstract Vorticity is a novel index that reflects diastolic function of left ventricle. The size the ventricle can influence ventricular blood flow. We evaluated effect on and intracardiac flow using particular species dogs, which has wide range body size. Vector mapping was used for evaluation flow, intraventricular pressure gradient (IVPG) function. 58 dogs weighing 1.3–42.3 kg were included in this study. found to be inversely proportional length chamber. Intraventricular difference...
Intraventricular pressure gradient is regarded as a non-invasive indicator of diastolic function. Salvianolic acid B (Sal-B), traditional Asian medicine, revealed its usefulness in myocardial infarction models; however, the hemodynamic effect salvianolic still unknown. The present study aimed to investigate intraventricular changes during development left ventricular hypertrophy with or without and beta-blocker.In total, 48 rats were divided into four groups; Sham, Non-treatment, B,...
Pulmonary hypertension (PH) is a complex syndrome that has been frequently diagnosed in dogs and humans can be detected by Doppler echocardiography invasive catheterization. Recently, PAWR attracts much attention as noninvasive approach for the early detection of PH. The present study aims to investigate changes acute pulmonary embolism (APE) highlight response variables vasodilator therapy dogs. For this purpose, anesthesia catheterization were performed 6 Beagle After that, APE was...
Myocardial infarction (MI) is one of the most common cardiac problems causing deaths in humans. Previously validated anesthetic agents used MI model establishment are currently controversial with severe restrictions because ethical concerns. The combination between medetomidine, midazolam, and butorphanol (MMB) commonly different animal models. possibility MMB to establish rats did not study yet which difficult respiratory depression delayed recovery post-surgery, resulting significant...