A5037212745- Cancer Cells and Metastasis
- Antibiotics Pharmacokinetics and Efficacy
- Cancer Research and Treatments
- Bladder and Urothelial Cancer Treatments
- 3D Printing in Biomedical Research
- Drug-Induced Hepatotoxicity and Protection
- Antibiotic Resistance in Bacteria
- Liver physiology and pathology
- Drug Transport and Resistance Mechanisms
- Tissue Engineering and Regenerative Medicine
- Cancer Genomics and Diagnostics
- Pharmacological Effects of Natural Compounds
- Electrospun Nanofibers in Biomedical Applications
- Pneumonia and Respiratory Infections
- Prostate Cancer Treatment and Research
- Microbial infections and disease research
- Polyamine Metabolism and Applications
- Epigenetics and DNA Methylation
- Coccidia and coccidiosis research
- Liver Disease Diagnosis and Treatment
- Pharmacogenetics and Drug Metabolism
- Additive Manufacturing and 3D Printing Technologies
- Brucella: diagnosis, epidemiology, treatment
- Nonlinear Differential Equations Analysis
- Helminth infection and control
Tokyo University of Agriculture and Technology
2015-2025
Benha University
2016-2025
University of Georgia
2023-2025
Kitasato University
2024
Al-Azhar University
2023
Al-Azhar University
2019-2022
University of Sadat City
2022
Agricultural Research Center
2021
Mansoura University
2020
Animal Health Research Institute
2019
Abstract In human and dogs, bladder cancer ( BC ) is the most common neoplasm affecting urinary tract. Dog resembles muscle‐invasive in histopathological characteristics gene expression profiles, could be an important research model for this disease. Cancer patient‐derived organoid culture can recapitulate organ structures maintains profiles of original tumor tissues. a previous study, we generated dog prostate organoids using urine samples, however had never been produced. Therefore aimed...
Due to the numerous pharmacological impacts of Spirulina platensis (SP), effects SP on oxidative status Nile tilapia farmed under chlorpyrifos (CPF) ambient toxicity were considered in this study. Fish (60 ± 6.1 g) was randomly stocked five groups where free diet fed control group while second one 1% without CPF exposure. Additionally, (15 μg/L) added water and fish with at 0, 0.5, (third, fourth, fifth groups, respectively). Samples blood gills, kidneys, liver tissues assayed for...
The present study aimed to investigate the prevalence, antibiotic susceptibility profiles, and some toxin genes of Panton-Valentine leukocidin (PVL)-positive Staphylococcus aureus (S. aureus) in unpasteurized raw cow's milk collected from retail outlets located at Mansoura, Dakahliya governorate, Egypt. In that context, a total 700 samples were investigated for presence S. aureus, which was identified 41.1% (288/700) samples. Among isolates, 113 PVL-positive subjected further analysis....
Methotrexate (MTX) is a chemotherapeutic medicine frequently used to treat various forms of cancer.The objective our research was examine whether allicin (ALC) and lycopene (LP) could alleviate the harmful effects MTXinduced testicular toxicity in rats.A total 49 male white albino rats were divided into 7 groups (7 each group).The group 1 kept as control received normal saline orally; while 2 3 administered ALC (20mg/kg/BW) LP (10mg/kg/BW) orally.On day 15, 4received single dose MTX...
Colorectal cancer is one of the most common causes death worldwide. In patients with metastatic colorectal cancer, combination treatment several anti-cancer drugs employed and improves overall survival in some patients. Nevertheless, disease are not cured owing to drug resistance. Cancer stem cells known regulate resistance chemotherapy. previous study, we established a novel three-dimensional organoid culture model from tumor tissues human using an air–liquid interface (ALI) method, which...
Bladder cancer (BC), a main neoplasm of urinary tract, is usually inoperable and unresponsive to chemotherapy. As novel experimental model for muscle-invasive BC, we previously established culture method dog BC organoids. In the present study, detailed in vitro vivo anti‐tumor effects trametinib were investigated by using this model. each organoid strain, epidermal growth factor receptor (EGFR)/ERK signaling was upregulated compared with normal bladder cells. Trametinib even at low...
Despite its adverse effects, chemotherapy is generally used for the treatment of colorectal cancer (CRC). Development supplement preparations targeting stem cells (CSCs) that cause distant metastasis and drug resistance required. Although curcumin known to have anti-tumor, hepatoprotective, hypoglycemic-like actions, low water solubility, oral absorption, bioavailability impede therapeutic uses. Patient-derived organoid cultures can recapitulate heterogeneity, epithelial structures,...
Brucellosis is a common zoonotic disease in Iran. Antimicrobial-resistant (AMR) Brucella isolates have been reported from different developing countries, posing an imminent health hazard. The objective of this study was to evaluate AMR and virulence-associated factors recovered humans animals regions Iran using classical phenotyping next generation sequencing (NGS) technology. Our findings revealed that B. melitensis the most species bovines, small ruminants camels. abortus isolated only one...
Despite its disadvantages, chemotherapy is still commonly used for the treatment of bladder cancer (BC). Developing natural supplements that can target stem cells (CSCs) which cause drug resistance and distant metastasis necessary. Chaga mushrooms are popular to have several health-promoting anti-cancer potentials. Organoid culture recapitulate tumor heterogeneity, epithelial environment, genetic molecular imprints original tissues. In previous study, we generated dog organoids (DBCO) as a...
Abstract Three-dimensional (3D) organoid culture holds great promises in cancer precision medicine. However, Matrigel and stem cell-stimulating supplements are necessary for culturing 3D cells. It costs a lot of money consumes more time effort compared with 2D cultured Therefore, the establishment cheaper Matrigel-free that can maintain characteristics part organoids is demanded. In previous study, we established dog bladder (BC) system by using their urine samples. Here, successfully...
Gibberellic acid (GA3), a widely known plant growth regulator, has been mostly used in agriculture. Little is regarding its toxicity or the impact of metabolic mechanism on human health. The current study examined protective chrysin against GA3-induced liver and kidney dysfunctions at biochemical, molecular, histopathological levels. Forty male albino rats were allocated into 4 groups. control group received saline; 50 mg/kg/BW orally daily for weeks; GA3 55 via oral gavage weeks, (chrysin +...
Dog bladder cancer (BC) is mostly muscle-invasive (MI) with poor prognosis, and its pathogenesis close to human MIBC. Three-dimensional (3D) organoid culture ensures novel knowledge on diseases including BC. Recently, we have established dog BC organoids (BCO) using their urine samples. BCO recapitulated the epithelial structures, characteristics, drug sensitivity of BC-diseased dogs. However, from normal epithelium are not yet. Therefore, present study aimed establish (NBO) for further...
Lapatinib is an orally administered tyrosine kinase inhibitor used to treat human epidermal growth factor receptor 2 (HER2) -overexpressing breast cancers in humans. Recently, the potential of lapatinib treatment against canine urothelial carcinoma or feline mammary tumor was investigated. However, pharmacokinetic studies dogs and cats are not well-defined. In present study, characteristics both after a single oral administration at dose 25 mg/kg were compared with each other. four female...
Cancer is the main health problem with high morbidity and mortality. The worldwide annual incidence deaths from cancers are estimated in millions [1,2]. Hence, cancer therapy must be continuous...