A5041771235- Ethics in Clinical Research
- Ethics in medical practice
- Biomedical Ethics and Regulation
- Climate Change and Health Impacts
- Patient-Provider Communication in Healthcare
- Microfinance and Financial Inclusion
- Air Quality and Health Impacts
- Pharmaceutical Practices and Patient Outcomes
- PI3K/AKT/mTOR signaling in cancer
- Liver Disease and Transplantation
- Nutrition, Health and Food Behavior
- Pharmacy and Medical Practices
- Agricultural risk and resilience
- Statistical Methods in Clinical Trials
- Liver Disease Diagnosis and Treatment
- Vitamin D Research Studies
- Influenza Virus Research Studies
- Cancer Mechanisms and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Spam and Phishing Detection
- Artificial Immune Systems Applications
- Machine Learning in Materials Science
- Crystallization and Solubility Studies
- Sleep and Work-Related Fatigue
- Statistical and Computational Modeling
Kyoto University
2011-2023
Kyoto University Hospital
2014-2020
Tokyo University of Science
2010-2020
The Institute of Statistical Mathematics
2014
Kyoto Women's University
2012-2014
Tohoku University
2012
Showa Pharmaceutical University
2010
National Institute of Technology, Numazu College
2001
St. Marianna University School of Medicine
1995
Background As a consequence of indoor occupations and reduced exposure to sunlight, concerns have been raised that vitamin D deficiency is widespread in developed countries. Vitamin known be associated with increased risks morbidity mortality various diseases. Objective To investigate the serum status its relation life-style factors pregnant Japanese women. Methods Among cohort for 3,327 women who participated an adjunct study Japan Environment Children's Study during 2011–2013, which data...
Several studies have suggested that lactoferrin administration may decrease the serum level of hepatitis C virus (HCV) RNA in patients with chronic C. The aim present study was to confirm efficacy orally administered bovine (bLF) randomly received either oral bLF at a dose 1.8 g daily for 12 weeks, or an placebo. primary endpoint virologic response, defined as 50% greater HCV weeks compared baseline. secondary biochemical which alanine aminotransferase (ALT) One hundred and ninety‐eight 199...
This study analyzed the change in liver fibrosis markers after Fontan operation and investigated their clinical usefulness as an index of congestive fibrosis.The enrolled 24 patients who underwent between January 1994 December 2008. We subdivided postoperative period into four intervals then compared hepatological during each. Eighteen cardiac catheterization correlation inferior vena cava (IVC) pressure was analyzed.The mean age 138.6 months interval examination 97.8 months. Type IV...
Asian dust storms originating from arid regions of Mongolia and China are a well-known springtime phenomenon throughout East Asia. Evidence is increasing for the adverse health effects caused by airborne desert inhalation. Given that people spend approximately 90 % their time indoors, indoor air quality significant concern. The present study aimed to examine influence outdoor particulate matter (PM) levels on PM during events under everyday conditions.
Introduction Desert dust is estimated to constitute about 35% of aerosol in the troposphere. Desertification, climatic variability and global warming all can contribute increased formation. This study aims examine possible health effects desert exposure on pregnant women their children. The purpose this report was present protocol. Methods analysis 4-year birth cohort began 2011 as an adjunct Japan Environment & Children’s Study (JECS) involving three regions: Kyoto, Toyama Tottori. JECS...
Despite development of markers for identification cancer stem cells, the mechanism underlying survival and division cells in breast remains unclear. Here we report that PKCλ expression was enriched basal-like cancer, among subtypes, correlated with ALDH1A3 (p = 0.016, χ2-test). Late stage patients expressing PKCλhigh ALDH1A3high had poorer disease-specific than those PKCλlow ALDH1A3low 0.018, log rank test Kaplan-Meier curves: hazard ratio 2.58, 95% CI 1.24–5.37, p 0.011, multivariate Cox...
Research Ethics Committees (RECs) are designed to protect human subjects in research. It is essential recognize whether the RECs achieving this goal. Several studies have reported on RECs; however, detailed data regarding quality of research protocols and review process not been Japan. We examine reviewed by processes at three institutions using a novel checklist we developed. The show that approximately half all examined lacked clearly written “Background” section defines study rationale...
To investigate the association between hours worked, symptoms experienced, and health resource utilization.Data were collected from a nationally representative sample of households in Japan. We studied full-time male workers aged 18-65 yr who worked 100 h or more per month. First, we examined experienced. Second, type utilized, such as physician visits, over-the-counter (OTC) medication use, dietary supplement complementary alternative medicine (CAM) provider visits. used multivariable...
Background Simplified informed consent forms have been successful in improving patient satisfaction and decreasing anxiety. However, unsolved problems remain about whether these documents improve comprehension of patients with standard literacy skills. Purposes To investigate a detailed form explaining the key elements consent, comparison to form, would increase adult cancer patients. Methods Patients who were eligible for National Surgical Adjuvant Study Breast Cancer (protocol...
We investigated levels of interest in clinical research among pharmacists working the field,and specific needs for education to nurture researchers.For this purpose,we conducted a questionnaire survey 240 participants the“Basic Seminar on Clinical Research Pharmacists”.The items included reason being interested research,enthusiasm participation research,recognition importance knowledge research,selfevaluation proficiency conducting research,and area interest.Responses were obtained from 204...
Background Vitamin D has been reported to affect both innate, and acquired immunity with immune cells such as dendritic having the vitamin receptors. The co-occurrence of high prevalence allergic diseases deficiency globally documented in recent decades, prompted a hypothesis on whether there is reasonable association between them. Objective To investigate serum symptoms. Methods Historical cohort. On cohort study for desert dust exposure symptoms 3,327 pregnant women during spring fall...
4076 Background: Intra-arterial cisplatin therapy for advanced hepatocellular carcinoma (HCC) has been reported a favorable tumor-shrinking effect and long-term survivals even in pts with highly HCC. The aim of this trial was to evaluate the efficacy safety ofsorafenib plus intra-arterial (SP) vs. sorafenib alone (S) Methods: In multicenter open-labeled randomized phase II trial, HCC no prior chemotherapy Child Pugh A or B7 were randomly assigned 2:1 receive SP (sorafenib: 800 mg, twice...
During the 6-year pharmacy program, students receive clinically oriented education that develops their expertise in effectively and safely managing patients' drug use. In our university, pre-hospital clinical training (PHCT) has been conducted during 4th year order to prepare for practical hospital community pharmacies 5th year. addition core curriculum, following six categories of advanced are performed PHCT: (1) basic life support based on American Heart Association guidelines...
The textbook conceptualization of phenotype creation, ``genotype (G) + environment (E) genotype \& interactions (GE) $\mapsto$ (Ph)'', is modeled with open quantum systems theory (OQST) or more generally adaptive dynamics theory(ADT). {\it model quantum-like}, i.e., it isn't about physical processes in biosystems. Generally such modeling applications the formalism and methodology outside physics. Macroscopic biosystems, our case genotypes phenotypes, are treated as information processors...
Background Surgery is recommended as the first-line treatment option to cure resectable gastrointestinal (GI) cancer. However, patients occasionally feel postoperative regret after surgery. To date, it not clear which factors are associated with patient GI cancer The aim of this study was investigate related decision in undergoing surgery for Methods present prospective used questionnaires analyze our institution between February and July 2020. Decision that felt quantitatively measured...
The aim of this study was to explore why patients accepted or declined participate in a randomized clinical trial, which subsequently discontinued because low recruitment rate.Forty-one were invited trial that aimed compare local ablation therapies and surgery treat small asymptomatic hepatocellular carcinomas. These then asked answer questionnaire assessed patient perception reasons for accepting declining enroll the trial. When had strong preference specific treatment, why, how when they...