A5101436780- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Ultrasound and Hyperthermia Applications
- Pancreatic and Hepatic Oncology Research
- MRI in cancer diagnosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Metastasis and carcinoma case studies
- Renal cell carcinoma treatment
- Neuroendocrine Tumor Research Advances
- Organ Transplantation Techniques and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Gallbladder and Bile Duct Disorders
- Genetic factors in colorectal cancer
- Inflammatory Bowel Disease
- Colorectal Cancer Treatments and Studies
- Esophageal and GI Pathology
- Photoacoustic and Ultrasonic Imaging
- Viral gastroenteritis research and epidemiology
Japanese Red Cross Hadano Hospital
2019-2024
Yokohama City University Medical Center
2012-2021
Yokohama City University
2012-2021
Red Cross Hospital
2019
Fukuda Denshi (Japan)
2017
Yamaguchi University
2012
Kindai University
2012
Toranomon Hospital
2012
Kurume University Hospital
2011
Kurume University
2011
To improve the efficacy of radiofrequency ablation (RFA) for treatment intermediate-sized hepatocellular carcinomas (HCCs), authors compared RFA combined with transcatheter arterial chemoembolization (TACE) to alone.The randomly assigned 37 patients solitary HCCs (diameter, 3.1-5.0 cm in greatest dimension) 2 groups: TACE-RFA group, which received TACE followed by on same day, and only RFA.Technical success was achieved after 1.4±0.5 sessions group 1.1±0.2 (P<.01). The mean diameters longer...
Potentially curative treatments for early‐stage hepatocellular carcinoma (HCC) have drawbacks and contraindications. Recently, radiotherapy has achieved good outcomes. We compared the outcomes of radiofrequency ablation (RFA) HCC. Consecutive patients with ≤3 HCC lesions tumor diameters cm treated RFA or were reviewed. was first choice unsuitable surgery. Otherwise, stereotactic body in five fractions mainly performed. For adjacent to gastrointestinal tract, mild hypofractionation Propensity...
Background & AimsPlatelet transfusion is used to prevent hemorrhagic events in patients with thrombocytopenia undergoing invasive procedures, but there are many disadvantages. We evaluated the efficacy and safety of lusutrombopag chronic liver disease procedures.MethodsWe performed a double-blind, parallel-group, phase 3 study 96 (platelet counts below 50,000/μL) procedures from October 2013 May 2014 at 81 centers Japan. Patients were randomly assigned (1:1) groups given once-daily (3 mg) or...
Immune checkpoint inhibitors (ICIs) are effective for advanced hepatocellular carcinoma (HCC). However, there few reports on the correlation between clinical efficacy of ICIs and development immune-related adverse events (irAEs) in patients with HCC. The aim this study was to investigate association irAE survival HCC treated atezolizumab plus bevacizumab.We enrolled 150 bevacizumab October 2020 2021 at 5 territorial institutions. We compared who experienced irAEs (irAE group) those did not...
To determine whether radiographic images after radiofrequency (RF)-induced coagulation necrosis are correlated with the pathologic effects, we evaluated morphology and histologic characteristics of RF ablation lesions over a 6-month follow-up period compared results those radiologic studies. Thirty-three hepatocellular carcinoma (HCC) tumors maximum diameter 3 cm or less were treated percutaneously by using in 26 patients. Six resected 4 weeks ablation; remaining 27 underwent biopsy...
The therapeutic effectiveness of a new combination therapy--pretreatment with transcatheter arterial embolization (TAE) and subsequent percutaneous ethanol injection (PEI)--for solitary large (> 3.0 cm in diameter) primary hepatocellular carcinoma lesions was compared that TAE alone. With alone, partial response the tumor seen only 10% patients, 1-, 2-, 3-year survival rates were calculated to be 68%, 37%, 0%, respectively. Histologic examination specimens obtained at hepatectomy showed...
Hepatitis C virus (HCV) is associated with the development of cirrhosis and hepatocellular carcinoma. We recently found that bovine lactoferrin, a milk protein belonging to iron transporter family, effectively prevented HCV infection in cultured human hepatocytes (PH5CH8). tested hypothesis lactoferrin inhibits viremia patients chronic hepatitis C. Eleven received an 8‐week course (1.8 or 3.6 g/day). At end treatment, decrease serum alanine transaminase RNA concentrations was apparent 3...
Effective prophylactic therapies have not been established for hepatocellular carcinoma recurrence. Peretinoin represents one novel option patients with hepatitis C virus-related (HCV-HCC), and it was tested in a multicenter, randomized, double-blind, placebo-controlled study. Patients curative therapy were assigned to of the following regimens: peretinoin 600, 300 mg/day, or placebo up 96 weeks. The primary outcome recurrence-free survival (RFS). Of 401 initially enrolled, 377 analyzed...
We evaluated the efficacy of fusion imaging that fuses conventional sonography images with hepatobiliary phase contrast-enhanced MR obtained gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) as reference image for detection hepatocellular carcinomas (HCCs).Eighty-seven HCCs a maximum diameter between 1 and 3 cm at time diagnosis were enrolled in this prospective study. compared rates using three modalities: sonography, late Sonazoid, combining MRI Gd-EOB-DTPA image....
Thrombocytopenia represents an obstacle for invasive procedures in chronic liver disease (CLD) patients. We aimed to estimate the appropriate dose and evaluate efficacy safety of lusutrombopag treatment thrombocytopenia before percutaneous radiofrequency ablation (RFA) primary hepatic cancer patients with CLD.In this multicenter, randomized, double-blind, placebo-controlled study conducted Japan, 61 CLD platelet count < 50 × 103/µL at screening were randomized placebo or 2, 3, 4 mg once...
Background: Low skeletal muscle mass is significantly associated with severe adverse events (AEs) from chemotherapy, and low tolerability leads to decreased survival. We aimed investigate whether body correlated prognosis in patients hepatocellular carcinoma (HCC) treated lenvatinib. Methods: This multicenter, retrospective study was conducted at five locations Japan. included 100 HCC Skeletal measured by computed tomography normalized for height m2 as index (SMI). The assessment criteria...
Abstract Background The efficacy of hepatic arterial infusion chemotherapy (HAIC) for advanced hepatocellular carcinoma (HCC) remains unclear. We conducted a multi-center randomized phase II study comparing sequential HAIC-sorafenib regimen versus sorafenib alone as an initial therapy HCC. Methods Patients were randomly assigned (ratio, 1:1) to receive HAIC with cisplatin followed by (HAIC group, n = 35) or (sorafenib 33) therapy. primary endpoint was the one-year survival rate. Secondary...
The natural immunomodulator, lactoferrin, is widespread among various biological fluids and known to exert an anti-inflammatory effect. However, there has been only one study that examined the mode of action lactoferrin in reducing intestinal damage. We investigated therapeutic role its effect on levels pro-inflammatory cytokines, by using a rat model dextran sulfate sodium (DSS) induced-colitis.Male Sprague-Dawley rats were given distilled drinking water containing 2.5% (wt/vol) synthetic...
We recently reported that lactoferrin (LF), a milk protein belonging to the iron transporter family, inhibits hepatitis C virus (HCV) infection in cultured human hepatocytes (PH5CH8) and interaction of LF with HCV is responsible for this inhibitory effect. As PH5CH8 cells were found be hepatocyte line susceptible B (HBV) infection, we therefore examined if could effectively prevent HBV cells. Preincubation cell bovine (bLF) or (hLF) was required cells, preincubation bLF hLF had no effect on...
Natural immunomodulator lactoferrin is known to exert an anti-inflammatory effect. However, there have been no studies that examine the mode of action in reducing intestinal damage. We investigated effect on a trinitrobenzenesulfonic acid (TNBS)-induced colitis model rats. Bovine was given once daily through gavage, starting 3 days before (preventive mode) or just after TNBS administration (treatment until death. The distal colon removed be examined. Colitis attenuated by via both modes...
We evaluated the usefulness of contrast-enhanced harmonic gray scale sonography with a newly developed sonographic contrast medium as means guidance for percutaneous ablation therapy hepatocellular carcinoma lesions not detected by conventional sonography.We examined 85 patients 108 that were identified hypervascular multidetector-row computed tomography using after injection Sonazoid (GE Healthcare, Oslo, Norway), lipid-stabilized suspension perfluorobutane gas microbubble agent. scanned...
Aim: Sorafenib is approved for the treatment of advanced hepatocellular carcinoma (HCC) in Japan; however, its tolerability and efficacy elderly patients with HCC have not been clarified. We aimed to evaluate sorafenib increasing age. Methods: As part a retrospective, multicenter cohort study conducted between May 2009 February 2010, received 400 mg twice daily (standard dosage) or once (half‐dosage) until disease progression intolerance. Results: The mean age enrolled ( n = 76) was 70.3...
We describe our experience with the application of a novel technology in which fluoroscopy and 3D imaging from C-arm cone beam CT systems are combined integrated navigation software.We applied this to five cases radiofrequency ablation was performed for hepatocellular carcinoma. Technical success achieved without treatment-related complications all cases. conclude that is potentially useful targeting hepatic lesions.
Objective. Ultrasonography (US) is a simple, inexpensive and minimally invasive method. We evaluated the vascularity of small intestinal lesions in Crohn's disease using color Doppler US (CD-US) retrospectively compared them with endoscopic surgical macroscopic findings. Material methods. In order to compare CD-US findings, 108 patients who underwent examination terminal ileum by both colonoscopy were included study. Vascularity was semiquantitative method, Limberg score. analyzed...