A5058488982- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Radiation Therapy and Dosimetry
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Radiotherapy Techniques
- Renal cell carcinoma treatment
- Osteoarthritis Treatment and Mechanisms
- Cancer Mechanisms and Therapy
- Macrophage Migration Inhibitory Factor
- Organ Transplantation Techniques and Outcomes
- Diet and metabolism studies
- Hepatitis Viruses Studies and Epidemiology
- Prostate Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Pharmacogenetics and Drug Metabolism
- Bone Tumor Diagnosis and Treatments
- Glioma Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Bariatric Surgery and Outcomes
Hitachi General Hospital
2021-2025
Tokai University
2018-2024
University of Tsukuba
2013-2024
Ibaraki Prefectural Central Hospital
2024
Maebashi Red Cross Hospital
2013-2022
Isesaki Fukushima Hospital
2015-2020
Isesaki Municipal Hospital
2015-2020
Gunma University
2007-2018
The Japanese Society of Gastroenterological Surgery
2016
Abstract Background The efficacy of hepatic arterial infusion chemotherapy (HAIC) for advanced hepatocellular carcinoma (HCC) remains unclear. We conducted a multi-center randomized phase II study comparing sequential HAIC-sorafenib regimen versus sorafenib alone as an initial therapy HCC. Methods Patients were randomly assigned (ratio, 1:1) to receive HAIC with cisplatin followed by (HAIC group, n = 35) or (sorafenib 33) therapy. primary endpoint was the one-year survival rate. Secondary...
Abstract Lacrimal sac tumors are rare, with approximately 800 cases reported worldwide; primary adenocarcinoma of the lacrimal is particularly rare. Although there no established treatment strategy, surgical removal generally performed. However, complete often requires extensive resection, including orbital exenteration and lateral rhinoplasty, which highly invasive creates significant cosmetic issues. Here, we report our experience a 72-year-old woman ethmoid bone invasion. She refused...
The aim of this study was to investigate the predictive factors objective response rate (ORR) and progression-free survival (PFS), correlation albumin-bilirubin (ALBI) grade with decreased appetite fatigue in hepatocellular carcinoma patients treated lenvatinib.From March 2018 December 2018, a total 94 included retrospective multicenter study.The median age all 73 years (interquartile range 66-79.3 years), approximately 78% were men. ALBI 1, 2, 3 27 (28.7%), 64 (68.1%), three (3.2%),...
Abstract Background and Aim: The pathophysiological mechanisms leading to the development of non‐alcoholic steatohepatitis (NASH) remain unclear. There are differences in susceptibility NASH between different species sexes. investigation precise mechanism interstrain may provide new means by which be understood. Methods: C57BL/6N C3H/HeN mice were administered a methionine‐ choline‐deficient (MCD) diet establish dietary model NASH. Results: An elevation serum alanine aminotransferase...
Abstract Aim Multiple molecular agents have been developed for treating unresectable hepatocellular carcinoma. This study aimed to elucidate the clinical efficacy of sequential treatment with lenvatinib after regorafenib failure. Methods From June 2017 October 2020, 63 patients Child–Pugh A and treated followed by sorafenib were enrolled (median age 71 years, 52 men, Barcelona Clinic Liver Cancer B:C = 23:40). They divided into two groups, those (R‐L group, n 47) who did not receive (non‐R‐L...
The aim of this study was to evaluate the efficacy proton beam therapy for pediatric patients with ependymoma.Proton conducted six (three boys and three girls; age, 2-6 years; median, 5 years) ependymoma. tumors were WHO grades 2 3 in two four patients, respectively. All underwent surgery (subtotal gross total resection each) at doses 50.4-61.2 GyE (median, 56.7 GyE). mean normal brain tissue photon radiotherapy simulated using same treatment planning computed tomography images.All completed...
The aim of this retrospective study was to investigate the efficacy and safety ramucirumab treatment under real-world conditions clarify role albumin-bilirubin (ALBI) score in predicting outcomes.Between June 2019 May 2020, a total 16 patients with advanced hepatocellular carcinoma (HCC) treated Gunma Saiseikai Maebashi Hospital its affiliated hospitals included.The median age 71 (interquartile range [IQR] 65-74) years old, 12 (75.0%) were male. modified ALBI (mALBI) grade 1, 2a, 2b at...
The nuclear receptor constitutive active/androstane (CAR) acts as a sensor of toxic byproducts derived from the endogenous metabolism and exogenous chemicals. We previously reported that CAR is responsible for exacerbating hepatic injury fibrosis in dietary model non-alcoholic steatohepatitis (NASH) via upregulation lipid peroxidation. In this study, we investigated pathological roles development hepatocellular carcinoma NASH model. +/+ −/− mice were fed methionine- choline-deficient (MCD)...
Abstract Aim We investigated the characteristics and prognosis of patients with hepatocellular carcinoma (HCC) diagnosed after sustained virological response (SVR) to antiviral therapy for chronic hepatitis C virus (HCV) infection, namely, eradication HCV, according surveillance status SVR. Methods In this multicenter study, liver function at HCC diagnosis progression among SVR were compared. Outcomes also investigated. Results not under SVR, was significantly more advanced diagnosis, tumors...
Abstract Liver metastases from gastric cancer (LMGC) is a non-curable, fatal disease with 5-year survival rate of <10%. Although various local treatments have been applied, their clinical utility has not established. The purpose this study was to investigate the safety and effectiveness proton beam therapy (PBT) for treatment patients LMGC. A total nine (seven men, two women; aged 56–78 years) LMGC who received PBT between 2002 2012 were retrospectively reviewed. Patients had tumors...
The aim of this multicenter retrospective study was to assess the change in liver function patients with hepatocellular carcinoma treated lenvatinib. Among 139 consecutive receiving lenvatinib treatment between March 2018 and July 2019, 28 Child-Pugh class B one patient inadequate information were excluded. Remaining 110 A analyzed. median age 73 years (IQR 66.7–80) 88 (80.0%) men. score 5 (CP5A) 6 (CP6A) 58 (52.7%) 52 (47.3%), ALBI grade 1 2 38 (34.5%) 72 (65.5%), respectively....
It was reported that proton beam therapy (PBT) reduced the normal brain dose compared with X-ray for pediatric tumors. We considered whether there not condition PBT more disadvantageous than intensity modulated photon radiotherapy (IMRT) and 3D conventional (3D-CRT) treatment of tumors about reduction when tumor location or size were different. The subjects 12 patients treated at our institute, including 6 cases ependymoma by local irradiation germinoma all four cerebral ventricles. IMRT...
To evaluate the clinical and virological features of acute hepatitis E (AH-E) in Gunma prefecture focus on virus (HEV) infection immunocompromised patients.A total 30 patients with AH-E diagnosed at our University Hospital, located 3-39-15 Showa-machi, Maebashi, 371-8511 Japan, its affiliated hospitals from 2004 to 2015, were studied. We evaluated detailed medical histories, laboratory examinations these participants.Of patients, 21 men, a median age 61 years. Three had history recent...
We retrospectively elucidated the oncological outcomes, prognostic factors and toxicities of proton beam therapy in trimodal bladder-preserving for muscle-invasive bladder cancer at our institution.From 1990 to 2015, 70 patients with cT2-3N0M0 underwent consisting maximal transurethral resection tumor, small pelvis photon irradiation, intra-arterial chemotherapy therapy. The overall survival rate, progression-free time progression, predictive progression were analyzed. Progression was...
Liver metastasis from breast cancer (LMBC) is an incurable, fatal disease with a very poor prognosis. Although various local treatments have been applied, their clinical utility has not established. The purpose of this study was to investigate the safety and effectiveness proton beam therapy (PBT) for treatment patients LMGC. A total 8 female (aged 38-63 years) LMBC who received PBT between 2002 2012 were retrospectively reviewed. Patients had tumors confined liver investigated, whereas...
Research on cartilage regeneration has developed novel sources for human chondrocytes and new regenerative therapies, but appropriate animal models translational research are needed. Although rabbit frequently used in such studies, the availability of immunocompromised rabbits is limited. Here, we investigated usefulness an immunosuppressed model to evaluate directly efficacy chondrocyte sheets through xenogeneic transplantation. Human were transplanted into knee osteochondral defects...
The term "ectopic varices" is used to describe dilated portosystemic collateral veins in unusual locations other than the gastroesophageal region. We recently experienced a rare case of ectopic varices that developed gastroduodenal anastomosis after subtotal gastrectomy. A 70-year-old male with liver cirrhosis due hepatitis C virus infection was admitted for hematemesis and tarry stool. He had received gastrectomy Billroth-I method gastric ulcer at 46 years age. Although emergency endoscopy...
Apoptosis via the Fas/Fas ligand signalling system plays an important role in development of various liver diseases. The administration agonistic anti-Fas antibody to mice causes massive hepatic apoptosis and fulminant failure. Several growth factors including hepatocyte factor (HGF) have been found prevent apoptosis.In this study, we demonstrated overexpression HGF a protective effect on Fas-mediated using transgenic (Tg mice) model.In Tg mice, elevation alanine aminotransferase was...
Valproic acid, a histone deacetylase (HDAC) inhibitor, induces the cytochrome P450 2B subfamily. However, effects of HDAC inhibitors on <i>CYP2B</i> induction are still not fully understood. Nuclear receptor constitutive androstane (CAR) is key regulator induction. In this study, we investigated effect CAR-mediated The expression CYP2B6 mRNA was induced in HepG2 cells stably expressing mouse CAR (Ym17) by including valproic phenylbutyrate, and trichostatin A. activated...