A5043758198- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- Extracellular vesicles in disease
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Mesenchymal stem cell research
- Pneumonia and Respiratory Infections
- Cancer Treatment and Pharmacology
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Gastric Cancer Management and Outcomes
- Mycobacterium research and diagnosis
- Bacterial Infections and Vaccines
- Gastrointestinal Bleeding Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Gut microbiota and health
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Transplantation Techniques and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Multiple Myeloma Research and Treatments
Nagoya University
2018-2025
Konan Kosei Hospital
2013-2023
Niigata University Medical and Dental Hospital
2019-2022
Niigata University
2018-2021
Japanese Red Cross Society Wakayama Medical Center
2019
Isesaki Municipal Hospital
2015-2016
Isesaki Fukushima Hospital
2015-2016
Gunma University
2016
Gunma Saiseikai Maebashi Hospital
2016
NTT Medical Center
2009-2011
Currently, there are no approved drugs for treating non-alcoholic steatohepatitis (NASH); however, mesenchymal stem cells (MSCs) and their small extracellular vesicles (sEVs), which possess immunomodulatory activities, potential candidates. This study aimed to develop a mouse model of NASH with rapid accumulation fibrosis using the pre-established melanocortin type-4 receptor knockout (Mc4r-KO) lipopolysaccharide (LPS), evaluate therapeutic effect MSCs sEVs.Mc4r-KO mice (8 weeks old, male)...
Abstract Next-generation sequencing (NGS) has been applied in the field of infectious diseases. Bronchoalveolar lavage fluid (BALF) is considered a sterile type specimen that suitable for detecting pathogens respiratory infections. The aim this study was to comprehensively identify causative using NGS BALF samples from immunocompetent pediatric patients with failure. Ten hospitalized failure were included. obtained acute phase used prepare DNA- and RNA-sequencing libraries. libraries...
Mesenchymal stem cells (MSCs) can be easily expanded. They acquired from medical waste such as adipose and umbilical cord tissues, are influenced by culturing conditions, exert anti-inflammatory, antioxidant, anti-fibrotic, angiogenic effects. We analyzed the multi-directional effects of MSCs cultured under hypoxic conditions their underlying mechanisms in treatment liver cirrhosis a mouse model.Human bone marrow-derived (5% O2; hypoMSCs) normoxic (21% norMSCs) were compared cap analysis...
ABSTRACT Background and Aims Interactions between the lung microbiome pulmonary epithelium plays a pivotal role in shaping immunity lung. Idiopathic fibrosis (IPF) is most common interstitial disease (ILD). Some patients with IPF develop episodic acute exacerbations often associated microbial dysbiosis lungs. This study aimed to investigate etiologic agents as well ILDs sarcoidosis. Methods analyzed 31 divided into (IPF‐stable, n = 12), exacerbation of (AE‐ILDs, 6), sarcoidosis ( 13) groups....
Myocarditis is an inflammatory disease of the myocardium and leads to cardiac dysfunction heart failure. Although viral infections are considered be most common etiology myocarditis, identification causative virus still challenging. Recently, next‐generation sequencing (NGS) has been applied in diagnosis infectious diseases. The aim current study was comprehensively analyze potential pathogenic microorganisms using NGS sera patients with myocarditis. Twelve pediatric five adult hospitalized...
Cytomegalovirus (CMV) is one of the most frequent pathogens for congenital infections. Most cases CMV infection (cCMV) are asymptomatic at birth, but sensorineural hearing loss (SNHL) or neurodevelopmental delay can appear later in childhood. This prospective study examined practicability serological screening anti-CMV immunoglobulin (Ig) G and IgM pregnant women. A total 11,753 women were IgG during first second trimester. When was positive, reevaluated more than two weeks later. negative,...
Mesenchymal stem cells (MSCs) can be acquired from medical waste. MSCs are easily expanded and have multiple functions, including anti-inflammatory effects. We evaluated the effects of human adipose tissue-derived (AD-MSCs) umbilical cord (UC-MSCs) in a dextran sulfate sodium (DSS)-induced mouse model. Human AD-MSCs UC-MSCs (1 × 106 cells) were injected intravenously into 7-day DSS-induced colitis The therapeutic cell origin, injection timing, supernatants obtained MSC cultures evaluated....
Febrile neutropenia (FN) is a frequent complication in immunocompromised patients. However, causative microorganisms are detected only 10% of This study aimed to detect the that cause FN using next-generation sequencing (NGS) identify genome derived from pathogenic bloodstream. Here, we implemented metagenomic approach comprehensively analyze present clinical samples patients with FN. defined as neutrophil count <500 cells/µL and fever ≥37.5°C. Plasma/serum 112 pediatric 10 without (NE) were...
To evaluate the clinical and virological features of acute hepatitis E (AH-E) in Gunma prefecture focus on virus (HEV) infection immunocompromised patients.A total 30 patients with AH-E diagnosed at our University Hospital, located 3-39-15 Showa-machi, Maebashi, 371-8511 Japan, its affiliated hospitals from 2004 to 2015, were studied. We evaluated detailed medical histories, laboratory examinations these participants.Of patients, 21 men, a median age 61 years. Three had history recent...
Rapid diagnosis of Mycoplasma pneumoniae pneumonia is required for timely treatment with effective antibiotics; however, PCR-based methods are often too expensive and technologically intensive general use in clinical practice. In this study, the efficacy loop-mediated isothermal amplification (LAMP) assay M. practice was prospectively evaluated. From July 2011 to March 2012, 531 children hospitalized community-acquired were enrolled. all patients, throat swabs obtained on admission detection...
In this study, we investigated the prevalence of antibodies against 9 viral species found in umbilical cord blood from 561 neonates 2013. Serum IgG following viruses were measured: herpes simplex virus (HSV), varicella-zoster (VZV), Epstein-Barr (EBV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6), measles (MV), rubella (RV), mumps (MuV), and parvovirus B19 (HPV B19). A survey questionnaire regarding past medical history maternal immunization status for vaccine-preventable diseases...
We conducted a retrospective study in 57 children (median age, 3.5 years; range, 1 month–14.5 years) with microbiologically confirmed pertussis infection over recent 4-year period regional hospital Japan. obtained nasal swabs from all patients for Bordetella isolation as well performed B. DNA detection using loop-mediated isothermal amplification (LAMP). Of the cases, 34 (60%) were culture-positive and (100%) LAMP-positive. The frequency of each symptom was follows: typical paroxysmal cough...
Liver cirrhosis is an end-stage multiple liver disease. Mesenchymal stem cells (MSCs) are attractive cell source for reducing damage and regressing fibrosis; additional therapies accompanying MSCs can potentially enhance their therapeutic effects. Kampo medicines exhibit anti-inflammatory anti-oxidative Here, we investigated the effect of combined with medicine Juzentaihoto (JTT) as a combination therapy in carbon tetrachloride (CCl4)-induced mouse model.C57BL/6 mice were administered JTT...
A unique European-type HEV strain (HE-JA12-0725) classifiable into subgenotype 3f was recovered from a 66-year-old Japanese female with autochthonous acute hepatitis E, and its entire genomic sequence determined characterized. The HE-JA12-0725 shared the highest identity of 92.7% Spanish swine isolate (EU723514) over genome possessed long hypervariable region 111 amino acids, identical to strains European origin. patient had consumed pork liver obtained via home delivery in Japan...
Abstract Background Immunosuppression during liver transplantation (LT) enables the prevention and treatment of organ rejection but poses a risk for severe infectious diseases. Immune modulation antimicrobials affect plasma microbiome. Thus, determining impact immunosuppression on microbiome may be important to understand immunocompetence, elucidate source infection, predict infection in LT recipients. We characterized recipients at early post-LT assessed association between clinical events....
Hepatitis E virus (HEV) infection has been recognized as an acute condition. However, recent reports have shown that immunocompromised patients, such those receiving solid‐organ transplantation, can develop chronic hepatitis with HEV infection. We report two cases of after kidney transplantation (KT) who were successfully treated ribavirin monotherapy. Several years KT, both patients had sustained elevations in the levels liver enzymes for a period more than 6 months. Both infection,...
Balloon-occluded transarterial chemoembolization (B-TACE) using a microballoon catheter is promising method for improvement of lipiodol emulsion accumulation and local control relative to conventional chemoembolization. This has been referred as the balloon anchor technique in previous reports. We report new successful parent advancement achievement stable backup selective insertion during B-TACE an anchor, even patients with tortuous anatomy hepatic celiac arteries. Deep cannulation...