A5100647942- Osteoarthritis Treatment and Mechanisms
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Knee injuries and reconstruction techniques
- Musculoskeletal pain and rehabilitation
- Color perception and design
- Periodontal Regeneration and Treatments
- Scoliosis diagnosis and treatment
- Silk-based biomaterials and applications
- Photoacoustic and Ultrasonic Imaging
- Acoustic Wave Resonator Technologies
- Urban and spatial planning
- Laser Applications in Dentistry and Medicine
- Medical Imaging and Analysis
- Pulmonary Hypertension Research and Treatments
- Pelvic and Acetabular Injuries
- Mesenchymal stem cell research
- Ferroelectric and Piezoelectric Materials
- Color Science and Applications
- Proteoglycans and glycosaminoglycans research
- Shoulder Injury and Treatment
- Cervical and Thoracic Myelopathy
- Total Knee Arthroplasty Outcomes
- Tendon Structure and Treatment
- Orthopaedic implants and arthroplasty
Tokai University
2016-2025
Tohoku University
1996-2024
Niigata University
2022-2024
Iwate Biotechnology Research Center
2024
IRYO Sosei University
2024
University of Pennsylvania
2019-2023
AO Foundation
2019-2023
Hashimoto Municipal Hospital
2021-2022
National Research Institute for Earth Science and Disaster Resilience
2017-2022
Jichi Medical University
2021
We propose Bit-Cost Scalable (BiCS) technology which realizes a multi-stacked memory array with few constant critical lithography steps regardless of number stacked layer to keep continuous reduction bit cost. In this technology, whole stack electrode plate is punched through and plugged by another material. SONOS type flash successfully applied achieve BiCS memory. Its cell concept, fabrication process characteristics key features are presented.
The electron-density map of an Si crystal is drawn by the maximum-entropy method (MEM) with 30 structure factors which were determined very accurately on absolute scale Pendellösung [Saka & Kato (1986). Acta Cryst. A42, 469-478]. It shown that following three beneficial points arise from use MEM for accurate analysis. Firstly, a precise can be obtained; existence bonding electrons clearly visible in map, even though no forbidden reflections are included calculated 222 and 442 show good...
Adult bone marrow contains mesenchymal stem cells (bone marrow-derived cells; BMSCs) which contribute to the generation of tissue such as bone, cartilage, muscle and adipose. However, using a source has limitation low cell number. An alternate adult that could be obtained in large quantities, under local anesthesia, with minimal discomfort would advantageous. Human adipose by liposuction was processed obtain fibroblast-like population or tissue-derived stromal (ATSCs). In this study, we...
The purpose of this study was to identify risk factors for surgical site infection after spine surgery, noting the amount saline used intraoperative irrigation minimize wound contamination.The authors studied 223 consecutive operations from January 2006 through December at our institute. For a case meet inclusion criteria as infection, it needed require incision and drainage show positive cultures. Preoperative data regarding each patient were collected. Patient characteristics recorded...
ABSTRACT Cartilage damage is typically treated by chondrocyte transplantation, mosaicplasty, or microfracture. Recent advances in tissue engineering have prompted research on techniques to repair articular cartilage using a variety of transplanted cells. We studied the and regeneration layered sheets prepared temperature‐responsive culture dish. previously reported achieving robust when covering only surface layer partial‐thickness defects with domestic rabbits. also good Safranin O staining...
Abstract Introduction Angiogenesis is an important factor in the development of osteoarthritis (OA). We investigated efficacy bevacizumab, antibody against vascular endothelial growth and inhibitor angiogenesis, treatment OA using a rabbit model anterior cruciate ligament transection. Methods First, we evaluated response gene expression histology normal joint to bevacizumab treatment. Next, induced by transection, used macroscopic histological evaluations real-time polymerase chain reaction...
Abstract Current cartilage regenerative therapies are not fully effective in treating osteoarthritis of the knee (OAK). We have developed chondrocyte sheets for autologous transplantation and tested these vitro vivo preclinical studies, reported that promoted hyaline repair rat, rabbit, minipig models. However, has yet to be humans. Here, we report our combination therapy which conventional surgical treatment OAK, is followed by sheet repair. Eight patients with OAK defects categorized...
Osteoarthritis of the knee (OAK) is a chronic degenerative disease and progresses with an imbalance cytokines macrophages in joint. Studies regarding use platelet-rich plasma (PRP) as point-of-care treatment for OAK have reported on its effect tissue repair suppression inflammation but few macrophage polarization. Based our clinical experience two types PRP kits Cellaid Serum Collection Set P type kit (leukocyte-poor-PRP) Autologous Protein Solution (APS leukocyte-rich-PRP), we investigated...
Low back pain (LBP) is a pervasive global health concern, primarily associated with intervertebral disc (IVD) degeneration. Although oxidative stress has been shown to contribute IVD degeneration, the underlying mechanisms remain undetermined. This study aimed unravel role of superoxide dismutase 2 (SOD2) in pathogenesis and target limit SOD2 demonstrated dynamic regulation surgically excised human tissues, initial upregulation moderate degeneration downregulation severely degenerated IVDs....
Application of ultraviolet (UV) irradiation to a photocrosslinkable chitosan (Az-CH-LA) aqueous solution resulted within 10 s in an insoluble, flexible hydrogel. A low molecular weight acidic molecule like trypan blue and various high molecules such as bovine serum albumin (BSA), heparin protamine were all retained the hydrogel, while basic toluidine was rapidly released from In present work, we examined retaining capability hydrogel for growth factors controlled release vitro vivo....
Cultured annulus fibrosus cells within an atelocollagen honeycomb-shaped scaffold with a membrane seal were allografted into the lacunas of intervertebral discs which nucleus pulposus had been vaporized using indocyanine green dye-enhanced laser. Regeneration disc was assessed based on viability and histologic status cells, as well prevention narrowing space.To study regeneration after laser discectomy tissue-engineering methods.Intervertebral is most avascular tissue in human body, its...
Application of ultraviolet light irradiation to a photocrosslinkable chitosan aqueous solution resulted in an insoluble, flexible hydrogel like soft rubber within 60 seconds. In order evaluate its accelerating effect on wound healing, full‐thickness skin incisions were made the backs mice and subsequently was added into irradiated with UV for 90 significantly induced contraction accelerated closure healing compared untreated controls. Histological examination also showed advanced rate first...
Abstract Human adipose tissue, obtained by liposuction, was processed to obtain a fibroblast‐like population of cells or tissue‐derived stromal (ATSCs). The ATSCs, as well bone marrow‐derived mesenchymal stem (BMSCs), have the capacity for renewal and potential differentiate into multiple lineages tissues. These are capable forming when implanted ectopically in an appropriate scaffold. aim this study evaluate β‐tricalcium phosphate (β‐TCP) scaffold compare osteogenic differentiation ATSCs...
MicroRNAs (miRNAs) are small RNAs of ∼22 base pairs that regulate gene expression. We harvested cartilage tissue from patients with polydactylism, anterior cruciate ligament injury, and osteoarthritis undergoing total knee arthroplasty used microarrays to identify miRNAs whose expression is upregulated or downregulated age. The results were assessed by real-time PCR MTT assay in a mimic group, which synthetic double-stranded RNA the isolated miRNA was transfected upregulate expression, an...
Lateral lumbar interbody fusion (LLIF) and bilateral percutaneous pedicle fixation are valuable, minimally invasive lateral approaches used to treat symptomatic degenerative disc disease. In the current procedure, patient's position on operating table is changed after LLIF surgery from decubitus prone position. The ability perform both with patient in same should reduce operation time. Use of a guide wire problematic during screw (PPS) insertion using fluoroscopy A new wire-less PPS system...
Computed tomography (CT) analyses have reported that the prevalence of diffuse idiopathic skeletal hyperostosis (DISH) in Japan is 8.7-27.1%. However, these data were obtained using chest-abdominal CT, and no evaluations sagittal, coronal, axial images whole-spine CT been reported. The aim this study was to investigate characteristic DISH by whole spinal CT.Participants patients who had experienced trauma undergone scanning based on initial clinical practice guidelines for our institute from...
Abstract Background There have been few comparisons between dual positions, which require a position change, and single position, does not it is clear whether there difference in indirect decompression achieved by the two procedures. Therefore, purpose of this study was to compare perioperative radiographic outcomes following lateral lumbar interbody fusion (LLIF) cohorts patients who underwent surgery or position. Methods This involved 45 at 68 levels, with LLIF percutaneous pedicle screw...
The relationship between spinal alignment and skeletal muscle mass (SMM) has attracted attention in recent years. Sagittal is known to deteriorate with age, but it not whether this related paraspinal muscles. Therefore, the purpose of study elucidate role multifidus (MF) psoas major (PS) muscles maintaining global patients lumbar stenosis (LSS) and/or degenerative spondylolisthesis (DS), analyze each muscles' cross-sectional area (CSA) correlates whole-body SMM using bioimpedance analysis...
We investigated the incidence and clinical features of cage subsidence after single-level lateral lumbar interbody fusion (LLIF). studied a retrospective cohort 59 patients (34 males, 25 females; mean age, 68.9 years) who received LLIF. Patients were classified into no-subsidence groups. Cage was defined as any violation either endplate, using radiographs computed tomography (CT) images. After one year, we compared patient characteristics, surgical parameters, radiological findings, pain...
Abstract Purpose To investigate the therapeutic potential of extracellular vesicles (EVs) derived from human nucleus pulposus cells (NPCs), with a specific emphasis on Tie2-enhanced NPCs, compared to EVs bone marrow-derived mesenchymal stromal (BM-MSCs) in coccygeal intervertebral disc degeneration (IDD) rat model. Methods were isolated healthy NPCs cultured under standard (NPC STD -EVs) and Tie2-enhancing Tie2+ conditions. characterized, their was assessed vitro degenerative terms cell...