A5084763256- Bird parasitology and diseases
- Animal Nutrition and Physiology
- Ocean Acidification Effects and Responses
- Marine animal studies overview
- Cardiovascular Function and Risk Factors
- Extracellular vesicles in disease
- RNA Research and Splicing
- Cardiovascular Conditions and Treatments
- MicroRNA in disease regulation
- Primate Behavior and Ecology
- RNA modifications and cancer
- Avian ecology and behavior
- Cancer-related molecular mechanisms research
- Inflammatory Biomarkers in Disease Prognosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ion channel regulation and function
- Anesthesia and Sedative Agents
- Tendon Structure and Treatment
- Cardiomyopathy and Myosin Studies
- Regulation of Appetite and Obesity
- Phagocytosis and Immune Regulation
- Immune Response and Inflammation
- Liver Disease Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Glycogen Storage Diseases and Myoclonus
Nihon University
2003-2025
Tokai University
2021-2024
National Institute of Biomedical Innovation, Health and Nutrition
2017-2023
Kumamoto University
2021
Physiol (Belgium)
2021
Nagoya University
1998
Abstract Purpose To investigate the therapeutic potential of extracellular vesicles (EVs) derived from human nucleus pulposus cells (NPCs), with a specific emphasis on Tie2-enhanced NPCs, compared to EVs bone marrow-derived mesenchymal stromal (BM-MSCs) in coccygeal intervertebral disc degeneration (IDD) rat model. Methods were isolated healthy NPCs cultured under standard (NPC STD -EVs) and Tie2-enhancing Tie2+ conditions. characterized, their was assessed vitro degenerative terms cell...
Spontaneous cardiac disease in nonhuman primates offers a useful model of human disease. However, diagnosing heart generally requires specialized techniques such as ultrasonography. This study focused on hormones that can be used to detect from blood tests. We measured concentrations atrial natriuretic peptide (ANP) and brain (BNP) healthy young Japanese macaques (Macaca fuscata) housed individually indoors, with no abnormalities thoracic X-rays, electrocardiograms, echocardiograms, or...
A case control study was conducted to estimate the prevalence of feather-damaging behavior and evaluate correlation with risk factors among pet psittacine birds in Japan. Although parrots is frequently observed Japan, its potential have not been investigated. Therefore, we an online questionnaire survey on parrot owners throughout Japan examine regional differences associated factors. In total, 2,331 valid responses were obtained. The 11.7%, general agreement prior studies. highest Cockatoos...
Various cardiovascular diseases can be detected and diagnosed using echocardiography. The demand for system research nonhuman primates is increasing, but echocardiographic references are limited. This report describes the first comparison of reference values in 247 normal cynomolgus monkeys (135 females, 112 males) over a wide age range. Echocardiography, electrocardiography, blood pressure chest X-ray images were acquired under immobilization with intramuscular ketamine hydrochloride, then...
The demand for monkeys medical research is increasing, because their ionic mechanism of repolarization similar to that humans. QT interval the distance between Q wave and T wave, but this affected by heart rate. Therefore, correction methods are commonly used in clinical settings. However, an accurate formula cynomolgus has not been reported. We assessed snapshot electrocardiograms (ECGs) 353 ketamine-immobilized monkeys, including aged animals, contrived a new corrected (QTc) as marker...
Acute liver injury (ALI) induced by chemicals or viruses can progress rapidly to acute failure (ALF), often resulting in death of patients without transplantation. Since transplantation is limited due a paucity donors, expensive surgical costs, and severe immune rejection, novel therapies are required treat injury. Extracellular vesicles (EVs) used for cellular communication, carrying RNAs, proteins, lipids delivering them intercellularly after being endocytosed target cells. Recently, it...
Lipid-mediated inflammation is involved in the development and malignancy of cancer. We previously demonstrated existence a novel oncogenic mechanism utilizing membrane lipids extracellular vesicles Epstein-Barr virus (EBV)-positive lymphomas found that lipid composition lymphoma cells skewed toward ω-3 fatty acids, which are anti-inflammatory lipids, suggesting an alteration systemic composition. The results showed arachidonic acid (AA), inflammatory lipid, was significantly reduced...
Abstract Aggressive natural killer cell leukemia (ANKL) is a rare hematological malignancy with fulminant clinical course. Our previous study revealed that ANKL cells proliferate predominantly in the liver sinusoids and strongly depend on transferrin supplementation. In addition, we demonstrated liver-resident are sensitive to PPMX-T003, an anti-human receptor 1 inhibitory antibody, whereas spleen-resident resistant inhibition. However, microenvironmental factors regulate iron dependency of...
Cynomolgus monkeys are closely related to humans phylogenetically, and this has resulted in their widespread use as a preclinical model. Hematological data with regard these thus important. Although reference values for blood components sex hormones have been established cynomolgus monkeys, those arterial gases not. The quickly reflect respiratory circulatory dynamics, useful animal management safe general anesthesia surgical operations. Furthermore, since O2 is transported by RBC, CBC...
Previous studies on dolphin electrocardiograms have shown that they are mainly composed of increased negative waves, similar to ungulates. The electrocardiogram waveform was determined by the distribution Purkinje fibers. Based electrocardiogram, Hamlin predicted fibers would be distributed within ventricular muscle, as in purpose this study confirm histological dolphins. In present study, bottlenose hearts were observed both grossly and histologically, effects fiber cardiac morphology...
Neutrophils are essential for innate immunity as the first line of defence. act phagocytic white blood cells to kill bacteria and other microorganisms. A strong respiratory burst neutrophils, dependent on reactive oxygen species, is produced during phagocytosis. Platelet-activating factor (PAF) a signalling molecule with several prominent roles in tissue injury, inflammation, platelet aggregation. However, detailed mechanisms intracellular pathways involved PAF-mediated neutrophil activation...
Cardiovascular disease (CVD) has a tremendous impact on the quality of life humans. While experimental animals are valuable to medical research as models human diseases, cardiac systems differ widely across various animal species. Thus, we examined CVD model in cynomolgus monkeys. Laboratory primates precious resources, making it imperative that symptoms diseases and disorders detected early possible. this study comprehensively important indicators monkeys, including arterial blood gas,...
Abstract Some RNAs such as 28S rRNA, U1 small nuclear RNA (snRNA), and Y are known to be cleaved during apoptosis. The underlying mechanism, functions, biological significance of degradation in apoptosis remain elusive. non-coding widely conserved from bacteria mammals, major components Ro ribonucleoprotein (RNP) complexes which contain the 60 kDa protein (SS-A) 50 La (SS-B). autoantigenic proteins were identified by autoantibodies present sera patients with Systemic lupus erythematosus...
There are currently no standard methods for diagnosing cardiac diseases in dolphins. These may consequently be overlooked and go undiagnosed. The presence severity of humans can determined using blood tests. Human atrial natriuretic peptide (hANP) used human examinations has low species specificity. have already been reports homology between dolphin ANP hANP; however, its potential clinical application dolphins not tested. This study was conducted to establish a reference plasma hANP levels...
The red panda (Ailurus fulgens) can be found in zoos around the world, and various behavioral restraint procedures are used as part of their health care. Wild animals that kept zoos, including pandas, known to have a longer life span than those wild. Therefore, management aging is considered especially important for maintain many precious wild animals. Blood pressure measurement determining cardiovascular dynamics, however there no reports blood measurements performed pandas without...
Left ventricular noncompaction (LVNC) involving genetic mutation is categorized as an unclassified cardiomyopathy, and its diagnostic criteria have not been standardized. This could be because precise animal models of LVNC created in any laboratory species. study aimed to analyze the pathophysiology familial tendency Japanese macaques. Two macaques with LVNC, their parents who were suspected having cardiac disease, examined. One macaque was examined using chest radiography, echocardiography,...
Intrauterine sperm injection for artificial insemination is difficult in cynomolgus macaques (Macaca fascicularis) and rhesus (M. mulatta) due to the complex structure of cervical canal, which differs from that humans. Despite availability several methods macaques, pregnancy rates are inconsistent, details regarding ovulation unclear, thus warranting more effective methods. Therefore, we developed an effective, ultrasound-guided, transabdominal intrauterine method involves timing coincide...
Although the number of reports describing tumors in aged NHP has increased, spontaneous neoplasias are extremely rare, with notable exception prosimians, which hepatic neoplasms arise. In addition to radiography and ultrasonography, superparamagnetic iron oxide (SPIO)-enhanced MRI tends be applied human practice non-invasively locate, identify, size liver define border between neoplastic normal tissues. Here we report a 13-y-old female cynomolgus monkey anorexia serologically enzymes. After...
Abstract Background Although some studies have reported cardiac diseases in macaques, an adequate screening method for enlargement has not yet been established. This study aimed to evaluate the positioning of macaques radiographs and establish reference intervals cardiothoracic ratio (CTR). Materials Methods We developed a device chest radiography sitting position performed 50 Japanese 48 rhesus CTR cavity size. Results In thorax height was significantly larger, heart width smaller, mean...
大腸癌の異時性他臓器重複癌の中で,小腸癌との組み合わせは極めて稀である.今回,直腸癌治癒切除術後の原発性小腸癌の1例を経験したので報告する.症例は70歳,女性,平成11年4月,直腸癌にて腹会陰式直腸切断術を施行した(高分化腺癌,a1,n0,stageII).平成12年末より鉄欠乏性貧血を認め,上部と下部消化管内視鏡検査を施行したが異常を認めず,その後の経過観察中も貧血を繰り返すため小腸造影を施行した.小腸に腫瘤像を認め,小腸腫瘍も考慮し平成13年3月,小腸部分切除術を施行した.中分化腺癌,seの原発性小腸癌であった.直腸癌術後の異時性小腸癌は,われわれが検索した限り極めて稀であった.癌の手術の既往のある患者において,持続する貧血に対し,小腸腫瘍も考慮し小腸造影を含め精査が必要であると考えられた.