A5102881474- Temporomandibular Joint Disorders
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Advanced Radiotherapy Techniques
- Spinal Fractures and Fixation Techniques
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Scoliosis diagnosis and treatment
- Bladder and Urothelial Cancer Treatments
- Ultrasound and Hyperthermia Applications
- Multiple and Secondary Primary Cancers
- Cerebrovascular and Carotid Artery Diseases
- Colorectal Cancer Screening and Detection
- Dental Radiography and Imaging
- Genetic factors in colorectal cancer
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Orthodontics and Dentofacial Orthopedics
- Gastrointestinal Tumor Research and Treatment
- Hernia repair and management
- Ovarian cancer diagnosis and treatment
- Urinary and Genital Oncology Studies
- Endometrial and Cervical Cancer Treatments
Takarazuka City Hospital
2021-2023
Tokai University
2010-2023
Kitasato University
2023
Anjo Kosei Hospital
2019-2022
Osaka Kaisei Hospital
2010-2022
JR Tokyo General Hospital
2021-2022
Osaka City General Hospital
2007-2020
Nara Medical University
2000-2020
National Cancer Center
2008-2019
National Hospital Organization
2018
Reported cases of pertussis among adolescents and adults have increased since the 1980s, despite increasingly high rates vaccination infants children. However, severe morbidity mortality occur primarily infants.To describe trends characteristics reported younger than 12 months in United States from 1980 to 1999.Cases National Notifiable Disease Surveillance System Centers for Control Prevention between 1999, detailed case data Supplementary Pertussis System.Incidence demographic clinical...
Abstract Objective To determine whether intervertebral disc (IVD) cells express β‐catenin and to assess the role of WNT/β‐catenin signaling pathway in cellular senescence aggrecan synthesis. Methods The expression messenger RNA (mRNA) protein rat IVD was assessed by using several real‐time reverse transcription–polymerase chain reaction, Western blot, immunohistochemical, immunofluorescence analyses. effect on nucleus pulposus (NP) examined transfection experiments, an MTT assay,...
Definitive chemoradiotherapy is one of the curative options for resectable esophageal squamous cell carcinoma with organ preservation. We evaluated efficacy and toxicity radiotherapy at a dose 50.4 Gy concurrent chemotherapy Stage II–III cancer. Esophageal cancer patients clinical (T1N1M0 or T2-3N0-1M0) were eligible. Radiotherapy was administered to total elective nodal irradiation 41.4 Gy. Concurrent comprised two courses 5-fluorouracil (1000 mg/m2/day) on days 1–4 2-h infusion cisplatin...
To evaluate the effectiveness of whole-pelvic hyperthermia (HT) added to standard chemoradiotherapy (CRT) in locally advanced cervical cancer (CC), by investigating clinical response and survival patients treated with cisplatin-based CRT vs. HT (CRT + HT).This study was conducted at five hospitals Japan between September 2001 March 2015 International Federation Gynecology Obstetrics stage IB (bulky)-IVA CC undergoing definitive CRT. After giving a written informed consent, were randomly...
The relationship between spinal alignment and skeletal muscle mass (SMM) has attracted attention in recent years. Sagittal is known to deteriorate with age, but it not whether this related paraspinal muscles. Therefore, the purpose of study elucidate role multifidus (MF) psoas major (PS) muscles maintaining global patients lumbar stenosis (LSS) and/or degenerative spondylolisthesis (DS), analyze each muscles' cross-sectional area (CSA) correlates whole-body SMM using bioimpedance analysis...
To evaluate the contribution of thermal dose parameters during regional hyperthermia (HT) treatment to clinical outcomes in patients with cervical carcinoma (CC) who received chemoradiotherapy (CRT) plus HT.Data from a multicentre randomised trial concurrent CRT + HT vs. alone were used efficacy and safety this combination therapy CC patients. The intrarectal temperatures undergoing recorded. complete data 47 (92%) 51 group available for analysis. Thus, included present study.Among HT,...
It remains unclear whether patients with metastatic castration-sensitive prostate cancer (mCSPC) are suitable for upfront docetaxel therapy. Therefore, we retrospectively evaluated castration-resistant (mCRPC) who could not receive ≥6 cycles of mCRPC. This study enrolled 274 diagnosed mCSPC later developed mCRPC, data at diagnosis, including blood test results, available from 17 hospitals between 2008 and 2022. Failure to was defined as receiving ≤5 mCRPC or dying due without Factors...
Abstract The purpose of this study was to compare the short-term clinical outcomes between extreme lateral interbody fusion (XLIF) and minimally invasive surgery (MIS)–transforaminal (TLIF) in patients with degenerative spondylolisthesis stenosis. One hundred-six were enrolled; 44 treated MIS–TLIF (direct decompression group; DP), 62 XLIF (indirect IDP). Perioperative indexes included operation time intraoperative bleeding. preoperative postoperative numeric rating scale (NRS) scores for low...
The involvement of intervertebral disc (IVD) tissues, whole blood (WB) cytokines, and chemokines in pain patients with lumbar degenerative disease (LDD) is unknown. We investigated the relationships between inflammatory cytokines human IVD tissues WB samples their association pain. Expression levels cytokine gene expression were measured from 20 LDD compared samples. associations chemokine intensity (numeric rating scale) also analyzed. mRNA C-C ligand (CCL20), receptor 6 (CCR6),...
Retrospective study.The purpose of this study was to compare the accuracy percutaneous pedicle screw (PPS) placement between prone and lateral decubitus positions during lumbar interbody fusion (LLIF) evaluate tendency PPS positioning based on simple computed tomography measurements with patients in position.There is insufficient information literature regarding inserting a using fluoroscopy position.We included 62 who underwent combined LLIF surgery fixation for degenerative...
We examined the antithrombotic effect of ticlopidine on occlusive thrombi small coronary arteries in (NZWxBXSB)F1 [(WxB)F1] male mice with myocardial infarction (MI) and systemic lupus erythematosus (SLE). Ticlopidine (3 10 mg/kg) was given to as an additive a standard laboratory diet from time were aged 16–24 weeks. The higher dose significantly increased survival rate mice. In that received mg/kg ticlopidine, incidence MI, percentage MI area (%MI), number significant stenosis lower than...
To evaluate the prognosis of our series patients with renal cell carcinoma (RCC) and tumor thrombus involving inferior vena cava (IVC) treated nephrectomy thrombectomy.In 46 unilateral RCC extending into IVC who underwent thrombectomy (T3b in 38 patients, T3c 6, T4 2, N+ 15, M1 21), overall cancer-specific survival rates were estimated, univariable multivariable analysis carried out to determine prognostic factors among age, gender, performance status, fever, inflammatory laboratory...
To characterize the temporal trends of stomach cancer mortality in Eastern Asia and to better interpret causes trends, we performed age, period cohort analysis (APC analysis) on rates Japan, Hong Kong Singapore during 1950-2004, as well US a control population. For APC analysis, Holford's approach was used avoid identification problem. Age-standardized (ASMR) decreased consistently all four areas observation both males females. Japan had highest ASMR sexes, followed by Singapore, US, but...
We investigated how skeletal muscle mass (SMM) affects spinal sagittal balance (radiographic parameters) in symptomatic patients. The first purpose of this study was to evaluate the body composition and alignment second compare whether is different patients with cervical spine disease lumbar disease. retrospectively evaluated 313 who were hospitalized for surgery treat degenerative disease, divided into groups. All underwent full-length standing whole-spine radiography bioimpedance analysis...
Abstract This study examined the ability of extreme lateral interbody fusion (XLIF) procedure to restore coronal and sagittal alignments for patients with adult spinal deformity (ASD) using computed tomography multiplanar reconstruction (CT-MPR). Thirty-eight ASD undergoing correction fixation XLIF at 114 levels were studied. The segmental Cobb angle, regional angle (L1-5), intervertebral disc height and, vertebral body rotation (VBR) measured before after surgery CT-MPR. mean VBR corrected...
To investigate the organ-specific response and clinical outcomes of mixed responses (MRs) to immune checkpoint inhibitors (ICIs) for unresectable or metastatic urothelial carcinoma (ur/mUC), we retrospectively analyzed 136 patients who received pembrolizumab. The total objective rate (ORR) ORR were determined each lesion according Response Evaluation Criteria in Solid Tumors version 1.1 as follows: (i) complete (CR), (ii) partial (PR), (iii) stable disease (SD), (iv) progressive (PD). Most...
Abstract The risk factors for severe radiation pneumonitis (RP) in patients with lung cancer who undergo rotating gantry intensity-modulated therapy (IMRT) using volumetric modulated arc (VMAT) or helical tomotherapy (HT) are poorly understood. Fifty-two received IMRT locally advanced were included this retrospective study. In total, 31 and 21 VMAT HT, respectively. median follow-up duration was 14 months (range, 5.2–33.6). Twenty (38%) eight (15%) developed grade ≥ 2 3 RP, multivariate...
Study design Retrospective case-series study Objectives To assess (1) low cone beam CT (CBCT) mediated intraoperative navigation to limit radiation exposure without compromising surgical accuracy, and (2) the potential of C-arm CBCT augment pedicle screw (PS) placement accuracy in AIS surgery compared pre-surgery CT-based planning. Methods The first part involved a prospective phantom study, comparing doses for conventional CT, standard (6sDCT) dose (5sDCT) Artis Zeego ® -imaging. Next,...
A study was undertaken to determine the maximum tolerated dose, dose-limiting toxicities, and response rate of irinotecan administered weekly with concurrent thoracic radiation therapy in patients locally advanced non-small-cell lung cancer. In a phase I/II clinical trial, histologically documented, surgically unresectable stage IIIA or IIIB non-small cell cancer (NSCLC) were enrolled. Irinotecan as 90 min intravenous infusion once for 6 weeks. The starting dose 30 mg m–2 escalation done 15...
We have previously indicated that a new soluble calpain inhibitor, SNJ-1945 (SNJ), attenuates cardiac dysfunction after cardioplegia arrest-reperfusion by inhibiting the proteolysis of α-fodrin in vitro study. Nevertheless, vivo study design is indispensable to explore realistic therapeutic approaches for clinical use. The aim present situ was investigate whether SNJ attenuated left ventricular (LV) (stunning) mild ischemic-reperfusion (mI-R) rat hearts. (60 μmol/l, 5 ml i.p.) injected 30...