A5020895628- Urinary Bladder and Prostate Research
- Bladder and Urothelial Cancer Treatments
- Pelvic floor disorders treatments
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urinary Tract Infections Management
- Urologic and reproductive health conditions
- Renal and Vascular Pathologies
- Dialysis and Renal Disease Management
- Renal cell carcinoma treatment
- Circadian rhythm and melatonin
- Pediatric Urology and Nephrology Studies
- Nutrition and Health in Aging
- Thermoregulation and physiological responses
- Organ Donation and Transplantation
- Cancer Immunotherapy and Biomarkers
- Ureteral procedures and complications
- Advanced Radiotherapy Techniques
- Sexual function and dysfunction studies
- Esophageal Cancer Research and Treatment
- Renal and related cancers
- Testicular diseases and treatments
- Genital Health and Disease
Nara Medical University
2016-2025
Nara Medical University Hospital
2008-2024
John Wiley & Sons (United States)
2019
Hudson Institute
2019
University of Pittsburgh
2003-2012
National Archives and Records Administration
2008-2009
Hoshigaoka Medical Center
2001
Tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) are reported to be associated with poor prognosis, depending on their pro-tumoral roles. Current knowledge of TAMs CAFs in the tumor microenvironment urothelial cancer bladder (UCB) is limited. Therefore, we investigated paracrine effect induced by human UCB. For this, first carried out immunohistochemical analysis for CXCL1, CD204 (TAM marker), αSMA (CAF E-cadherin, MMP2 using 155 UBC tissue samples. Next,...
Current knowledge of the molecular mechanism driving tumor budding is limited. Here, we focused on elucidating detailed underlying in urothelial cancer bladder. Invasive was pathologically classified into three groups as follows: nodular, trabecular, and infiltrative (tumor budding). Pathohistological analysis orthotopic model revealed that human cell lines MGH-U3, UM-UC-14, UM-UC-3 displayed typical patterns, respectively. Based results comprehensive gene expression using microarray (25 K...
The clinical significance of regulatory T cells (Treg) and tumor-associated macrophages (TAM) in the tumor microenvironment human bladder cancer remains unclear. aim this study is to explore their relevance oncological features non-muscle invasive (NMIBC). We carried out immunohistochemical analysis forkhead box P3 (FOXP3, Treg maker), CD204 (TAM marker), interleukin-6 (IL6) using surgical specimens obtained from 154 NMIBC patients. TAM counts surrounding lesion IL6-positive cell were...
Real-world evidence regarding enfortumab vedotin for unresectable or metastatic urothelial carcinoma is scarce, particularly in Japan. We investigated real-world data focusing on patient background, previous treatments, response, survival and adverse events patients receiving vedotin.
We investigated the impact of intraoperative tumor capsule injury (TCI) during robot-assisted partial nephrectomy (RAPN) or laparoscopic (LPN) on oncological outcomes, as well underlying factors TCI for improving surgical outcomes. A total 253 patients who underwent RAPN LPN between 2010 and 2022 were retrospectively analyzed divided into two groups: non-TCI groups. The background was compared records video to evaluate seek possible causes TCI. Multivariate logistic regression analysis...
Although the significance of preoperative nutritional status has been investigated, there is no report regarding relationship their postoperative changes on outcomes in patients who underwent radical cystectomy for bladder cancer. Here, we clinical impact change, from baseline, and volume abdominal skeletal muscle mass adipose tissue after cystetomy. A retrospective analysis 89 with cancer, curative cystectomy, was conducted to assess time course body composition at 1, 3, 6, 12, 24 months,...
The present study evaluated the clinical relevance of an integrative preoperative assessment inflammation-, nutrition-, and muscle-based markers for patients with muscle-invasive bladder cancer (MIBC) undergoing curative radical cystectomy (RC).The analysis enrolled 117 variables included age, body mass index (BMI), neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte platelet-to-lymphocyte modified Glasgow Prognostic Score (mGPS), prognostic nutritional (PNI), Controlling Nutritional...
The evidence of association between sexually transmitted infection and prostatic inflammation in human prostate cancer (PCa) is limited. Here, we sought to examine the potential with inflammatory environment carcinogenesis. We screened surgical biopsy specimens from 45 patients PCa against a panel infection-related organisms using polymerase chain reaction examined severity intraprostatic by pathologic examination. Among tested organisms, rate Mycoplasma genitalium (Mg) was significantly...
The urethral closure mechanism under a stress condition induced by sneezing was investigated in urethane-anesthetized female rats. During sneezing, while the responses measured microtip transducer catheters proximal and middle parts of urethra increased, response almost negligible when bladder subtracted from or abdomen opened. In contrast, during still observed after subtracting opening abdomen. These were significantly reduced approximately 80% bilateral transection pudendal nerves to...
Chemotherapy drugs, such as gemcitabine and cisplatin (GC), are frequently administered to patients with advanced urothelial carcinoma, however the influence of gut microbiota on their action is unclear. Thus, we investigated effects GC microbiome determined whether oral supplementation a probiotics mixture Lactobacillus casei Shirota Bifidobacterium breve enhanced anti-tumor immune response. After subcutaneous inoculation MBT2 murine bladder cancer cells, syngenic C3H mice were randomly...
We investigated the effects of diabetes mellitus (DM) on urethral relaxation mechanisms during reflex bladder contractions in rats.Five weeks after streptozotocin injection (65 mg/kg intraperitoneally) DM were evaluated by simultaneous recordings intravesical pressure under isovolumetric conditions and perfusion (UPP) using urethane anesthesia.In diabetic rats UPP nadir thresholds for inducing significantly higher (199% 92%, respectively) than normal rats, while baseline UPPs not different....
Urethral closure mechanisms during passive increments in intravesicular pressure (P(ves)) were investigated using microtip transducer catheters urethane-anesthetized female rats. After a block of reflex bladder contractions by spinal cord transection at T8-T9, abruptly raising P(ves) to 20, 40, or 60 cmH(2)O for 2 min induced pressure-dependent contractile response restricted portion the middle urethra (12.5-15 mm from urethral orifice) that was abolished cutting pelvic nerves bilaterally....
Objective To determine the prognostic factors of primary T1 high‐grade bladder cancer and to validate Spanish Urological Club for Oncological Treatment model in Japanese patients with treated at a single institution. Methods Records 106 from 1998 2013 were retrospectively reviewed. Variables included various clinicopathological parameters, including lymphovascular invasion tumor growth pattern front. Recurrence‐free survival progression‐free analyzed. Multivariate Cox proportional regression...
Collagen type 4 alpha 1 ( COL 4A1) and collagen 13 13A1) produced by urothelial cancer cells support the vital oncogenic property of tumor invasion. We investigated diagnostic prognostic capability 4A1 13A1 in voided urine compared observed values with those fragments cytokeratin‐19 CYFRA 21‐1), nuclear matrix protein 22 NMP ‐22), cytology bladder BC a). collected samples from 154 patients newly diagnosed a, before surgery 61 control subjects. Protein levels 4A1, 13A1, 21‐1, ‐22 supernatants...
Background/Objectives: The number of older adults requiring a kidney transplant (KT) is increasing; hence, postoperative sarcopenia prevention necessary. KT recipients require permanent oral immunosuppressants (ISs), and the gut microbiota (GM) plays role in various systemic diseases. However, few studies have evaluated post-kidney transplantation frailty associations among ISs, GM, muscle mass alterations. Therefore, we investigated effects ISs on GM skeletal mice human recipients. Methods:...
This study aimed to evaluate the clinical outcomes of patients who developed prostate-specific antigen failure after radical prostatectomy and were treated with salvage radiotherapy (SRT). retrospective included 167 received SRT between January 2008 August 2017 at a single center. Cumulative periodic genitourinary gastrointestinal adverse events chronologic changes in quality life evaluated before 1, 3, 6, 12, 24, 36, 48, 60 months SRT. The median follow-up duration was 83 months. 5- 7-year...
ABSTRACT Objective A stepwise approach is recommended for the treatment of daytime urinary incontinence, with standard urotherapy as first‐line treatment, followed by pharmacological when unsuccessful. This study was aimed at characterizing and comparing children an overactive bladder incontinence who became continent solely on those achieved continence a combination treatment. Methods retrospective included 221 patients complete during day. Results Of these patients, 104 (47%) were...
ABSTRACT Objectives To explore the efficacy and safety of thulium laser vaporization prostate (ThuVAP) for benign prostatic hyperplasia (BPH) at Nara Medical University from 2022 to 2024. Methods Patients with BPH who underwent ThuVAP Department Urology, University, between January 01, April 30, 2024, were enrolled. Patient background, presurgical pressure flow study results, treatment efficacy, retrospectively evaluated. Results The included 32 patients; median age was 74.5 years surgery....
The clinical importance of fracture prevention in patients with end-stage renal disease is well-established. We investigated the roles bone metabolism-related serum biomarkers and nutritional markers for fractures Japanese living-donor kidney transplant recipients. included 204 consecutive who underwent transplantation at Nara Medical University between 2003 2022 retrospectively reviewed their medical charts. cumulative incidence was by focusing on markers, related were explored. age surgery...
The aim of this study was to evaluate the effect supplementing healthy men with soy isoflavones on serum levels sex hormones implicated in prostate cancer development. A total 28 Japanese volunteers (18 equol producers and 10 non-producers) between 30 59 years age were given (60 mg daily) supplements for 3 months, changes their hormone investigated at baseline after administration. urine concentrations daidzein, genistein, fasting blood samples 24-h stored also measured. All completed...
Increased nocturnal urinary volume is closely associated with nocturia. We investigated the relationship between polyuria and variation of body fluid distribution during daytime using bioelectric impedance analysis.A total 34 men older than 60 years were enrolled in this study. A frequency chart was recorded. Nocturnal defined as a urine per 24-hour production greater 0.35 (the index). Bioelectric analysis performed 4 times daily at 8 11 a.m., 5 9 p.m. an InBody S20 composition analyzer...
Clinical evidence regarding risk reduction of repeated bladder recurrence after initial photodynamic diagnosis (PDD)-assisted transurethral resection tumor (TURBT) is still limited in patients with non-muscle-invasive cancer (NMIBC). We analyzed primary NMIBC undergoing TURBT without any adjuvant treatment to compare the cumulative between conventional white-light (WL)-TURBT and PDD-TURBT. Out 430 diagnosed from 2010 2019, 40 WL-TURBT 60 PDD-TURBT were eligible. Multivariate Cox regression...