A5101976111- Neonatal Respiratory Health Research
- Clinical Nutrition and Gastroenterology
- Lung Cancer Diagnosis and Treatment
- Malaria Research and Control
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiation Therapy and Dosimetry
- Oral and Maxillofacial Pathology
- Mosquito-borne diseases and control
- Head and Neck Cancer Studies
- Congenital Anomalies and Fetal Surgery
- Salivary Gland Tumors Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Atmospheric Ozone and Climate
- Bone Tumor Diagnosis and Treatments
- Ear and Head Tumors
- Advanced Radiotherapy Techniques
- Congenital Diaphragmatic Hernia Studies
- Organ Transplantation Techniques and Outcomes
- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Parkinson's Disease Mechanisms and Treatments
- Schizophrenia research and treatment
- Ionosphere and magnetosphere dynamics
- Environmental DNA in Biodiversity Studies
- Head and Neck Surgical Oncology
University of Tsukuba
1980-2025
Taoka Hospital
2023-2024
University of Tsukuba Hospital
2020-2024
Pfizer (Japan)
2023-2024
Niigata University of Health and Welfare
2023
Tsukuba Medical Center Hospital
2023
Ibaraki Prefectural Central Hospital
2023
Sumitomo Dainippon Pharma (Japan)
2016-2021
Fukuoka University
2011-2021
Fukuoka University Hospital
2014-2021
Many plants contain latex that exudes when leaves are damaged, and a number of proteins enzymes have been found in it. The roles those as yet poorly understood. We papain, cysteine protease the Papaya tree (Carica papaya, Caricaceae), is crucial factor defense papaya against lepidopteran larvae such oligophagous Samia ricini (Saturniidae) two notorious polyphagous pests, Mamestra brassicae (Noctuidae) Spodoptera litura (Noctuidae). Leaves laticiferous plants, including wild fig, Ficus...
Rationale: Respiratory syncytial virus (RSV) induces not only infantile recurrent wheezing but also potentially atopic asthma.Objectives: To test the effect of RSV infection on development subsequent asthma, we evaluated whether palivizumab, an anti-RSV monoclonal antibody, by preventing severe disease in first year life, could impact and asthma at 6 years age.Methods: During 2007 to 2008 season, decision administer palivizumab was made based standard medical practice observational...
To compare late renal effects in pediatric and adult patients with malignancies after PBT involving part of the kidney. A retrospective study was conducted to assess changes volume function 24 patients, including 12 children (1–14 years old) adults (51–80 old). Kidney volumes were measured from CT or MRI images during follow-up. Dose-volume histograms calculated using a treatment planning system. In children, median for irradiated control kidneys −5.58 (−94.95 +4.79) +14.92 (−19.45 +53.89)...
<h3>Objective</h3> To investigate the efficacy and safety of zonisamide as an adjunct to levodopa therapy for parkinsonism in patients with dementia Lewy bodies (DLB). <h3>Methods</h3> This phase 2, placebo-controlled, randomized, double-blind study consisted run-in (placebo, 4 weeks) treatment (placebo or 25 50 mg once daily, 12 periods. Outpatients diagnosed probable DLB were eligible inclusion. The primary endpoint was change from baseline Unified Parkinson9s Disease Rating Scale (UPDRS)...
Follow-up after treatment for hepatocellular carcinoma (HCC) can be mostly performed using dynamic CT or MRI, but there is no common evaluation method radiation therapy. The purpose of this study to examine factors involved in tumor reduction and local recurrence patients with HCC treated proton beam therapy (PBT) evaluate shrinkage PBT. Cases only one irradiated lesion those two lesions simultaneously were included study. Pre- post-treatment evaluated Response Evaluation Criteria Solid...
Abstract Lacrimal sac tumors are rare, with approximately 800 cases reported worldwide; primary adenocarcinoma of the lacrimal is particularly rare. Although there no established treatment strategy, surgical removal generally performed. However, complete often requires extensive resection, including orbital exenteration and lateral rhinoplasty, which highly invasive creates significant cosmetic issues. Here, we report our experience a 72-year-old woman ethmoid bone invasion. She refused...
The absolute rate constant for light emission from the NO–O reaction has been determined, as a function of wavelength, by using standard brightness source, which surface uniform brightness. spectral distribution measured between 0.4 and 1.4 μm is in good agreement with those previous studies except little difference near infrared region. influence NO–O3 chemiluminescence demonstrated atomic oxygen production O2 discharges.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTL-Asparaginase form Proteus vulgaris. Purification, crystallization, and enzymic propertiesTetsuya Tosa, Ryujiro Sano, Kozo Yamamoto, Masatoshi Nakamura, Ichiro ChibataCite this: Biochemistry 1972, 11, 2, 217–222Publication Date (Print):January 18, 1972Publication History Published online1 May 2002Published inissue 18 January 1972https://pubs.acs.org/doi/10.1021/bi00752a012https://doi.org/10.1021/bi00752a012research-articleACS PublicationsRequest...
Abstract Introduction To evaluate efficacy and safety of lurasidone for the treatment Asian patients with schizophrenia. Methods Patients schizophrenia from Japan, South Korea, Malaysia, Taiwan were randomly assigned to 6 weeks double‐blind 40 or 80 mg/d placebo. The primary measure was change baseline week on Positive Negative Syndrome Scale (PANSS) total score. Efficacy evaluated using a mixed‐model repeated‐measures (MMRM) analysis in modified intention‐to‐treat (mITT) population. Results...
Background & AimsTreatment options for irritable bowel syndrome with constipation (IBS-C) are limited—new prokinetic drugs needed. We evaluated the efficacy and safety of minesapride (DSP-6952), a partial agonist high affinity 5-HT4 receptors, in patients IBS-C Japan.MethodsWe performed double-blind phase 2 study 171 Rome III-defined at 33 centers Japan, from December 2012 through August 2013. Patients were randomly assigned to groups given (1, 4, 12, or 40 mg) placebo once daily 4 weeks....
Background. Monitoring the prevalence of drug resistant Plasmodium falciparum is essential for effective malaria control. Resistance to pyrimethamine and sulfadoxine increases as mutations accumulate in parasite genes encoding dihydrofolate reductase (dhfr) dihydropteroate synthase (dhps), respectively. Although parasites are exposed these antifolate drugs simultaneously, it remains virtually unknown whether dhfr dhps along interrelated paths. Methods. We investigated order step-wise...
Altitude distributions of the (0, 0) 7619‐Å band O 2 atmospheric system ( b ¹Σ g + ‐, X 3 Σ − ) and (7, 2) 6863‐Å OH ²Π) in night airglow emissions were measured at 31°N latitude. In spite different seasons local times observations, all three measurements presented peak emission rate occurring an altitude 94±1 km for 90±2 band. The former emitting is basic agreement with atomic oxygen density profile as by using I 1300‐Å resonance lamp, but latter considerably higher than expected from...
Aim The aim of this study was to evaluate the efficacy lurasidone in acute schizophrenia Japan and other countries. Methods Subjects (aged 18–74 years) diagnosed with were randomized 40 mg/day or placebo. primary endpoint change from baseline on Positive Negative Syndrome Scale (PANSS) total score at Week 6. Secondary assessments included Clinical Global Impression‐Severity (CGI‐S). Safety endpoints adverse events, laboratory electrocardiogram parameters. Results A 483 subjects placebo; 107...
Background/Aim: Curing local recurrence of rectal cancer (LRRC) is difficult with conventional photon radiotherapy. Proton beam therapy (PBT) on the other hand, has unique physical characteristics that permit higher doses to LRRC while minimizing side effects surrounding organs. However, efficacy PBT controlling not yet been reported. This study aimed evaluate clinical outcomes and toxicities for LRRC. Patients Methods: Clinical were retrospectively evaluated 12 patients 13 total lesions had...
In Plasmodium falciparum, resistance to chloroquine (CQ) is conferred by a K T mutation at amino acid position 76 (K76T) in the P. falciparum CQ transporter (PfCRT). To date, least 15 pfcrt genotypes, which are represented combinations of five acids positions 72-76, have been described field isolates from various endemic regions. identify novel mutant genotypes and reveal genetic relatedness large-scale survey over wide geographic area was performed.Sequences for exon 2 pfcrt, including...
Hepatic hemangiomas are benign tumors with a favorable prognosis, but giant hepatic can cause abdominal symptoms and indicated for treatment. Most cases treated surgery, radiotherapy has also been used. However, to date, there have no reports of proton beam therapy hemangioma.A 46-year-old woman had tumor 80 × mm in the left medial lobe liver, which was diagnosed as hemangioma based on contrast pattern. Therapy required symptoms, patient refused blood transfusion due religious reasons, made...
Because of advances in parenteral nutrition (PN), the prognosis for patients with short bowel syndrome (SBS) has recently shown great improvement. Even infants a small measuring only 20 cm either or without an ileocoecal valve can now survive. However, because increased periods PN, severe complications associated PN have been observed.We analyzed 17 SBS treated by long-term to investigate particularly hepatic dysfunction, micronutrient deficiency, and intoxication.Eleven (64.7%) had mostly...
Background and Methods: The administration of trace elements is thought to be needed in patients receiving long‐term parenteral nutrition. Recently, manganese intoxication or deposition was documented such patients. We report two cases during intermittent nutrition including manganese. Manganese had been administered for 4 years at a frequency one times per week case 5 month the other case. Both showed mild symptoms with headache dizziness. One hepatic dysfunction did not. whole‐blood level...
Height distributions of the OI 5577Å, O2 Herzberg and Atmospheric bands in night airglow were simultaneously measured with photometers on board a rocket flown from Uchinoura (31°N). The volume emission rates attained its maximum at height 96 km for 97km 94km band, being agreement previous observations. ratio to 5577Å exhibited constant value height, that band varied proportion atmospheric density. Some implications excitation mechanism are presented discussed according this result along...