A5002635502- Malaria Research and Control
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Parasites and Host Interactions
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- T-cell and B-cell Immunology
- Parasite Biology and Host Interactions
- Viral Infections and Outbreaks Research
- Complement system in diseases
- Immunotherapy and Immune Responses
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- Computational Drug Discovery Methods
- Helminth infection and control
- Heme Oxygenase-1 and Carbon Monoxide
- Monoclonal and Polyclonal Antibodies Research
- Hemoglobinopathies and Related Disorders
- Ginseng Biological Effects and Applications
- Global Maternal and Child Health
- Meta-analysis and systematic reviews
- Ethics in Clinical Research
- COVID-19 epidemiological studies
- Morinda citrifolia extract uses
- COVID-19 Clinical Research Studies
Nagasaki University
2016-2025
University of Nagasaki
2013-2023
University of Toyama
2020-2021
Komatsu (Japan)
2020-2021
Google (United States)
2021
University of Kinshasa
2021
The University of Adelaide
2020
Minia University
2020
Weatherford College
2020
Ton Duc Thang University
2019
Background Recent in-vitro studies have suggested that mast cells are involved in Dengue virus infection. To clarify the role of development clinical fever, we compared plasma levels several cell-derived mediators (vascular endothelial cell growth factor [VEGF], soluble VEGF receptors [sVEGFRs], tryptase, and chymase) -related cytokines (IL-4, -9, -17) between patients with differing severity fever healthy controls. Methodology/Principal Findings The study was performed at Children's...
Given the current absence of specific drugs or vaccines for Ebola virus disease (EVD), rapid, sensitive, and reliable diagnostic methods are required to stem transmission chain disease. We have developed a rapid detection assay Zaire ebolavirus based on reverse transcription-loop-mediated isothermal amplification (RT-LAMP) coupled with novel portable platform. The RT-LAMP is primer sets that target untranscribed trailer region nucleoprotein coding viral RNA. test could specifically detect...
Background Dengue virus (DV) infection is one of the most important mosquito-borne diseases in tropics. Recently, severe forms, dengue hemorrhagic fever (DHF) and shock syndrome (DSS), have become leading cause death among children Southern Vietnam. Protective and/or pathogenic T cell immunity supposed to be pathogenesis DHF DSS. Methodology/Principal Findings To identify HLA alleles controlling against (DV), we performed a hospital-based case control study at Children's Hospital No.2, Ho...
The acute manifestations of dengue are well known. clinical symptoms that present during the convalescent phase infection less characterized, but may be autoimmune-based. This study was undertaken to determine prevalence persistent among individuals infected 2006 Cuban epidemic and evaluate immunological genetic factors associated with their occurrence.In 2008, data blood samples were collected from a random sample adult diagnosed fever (DF, n=68), hemorrhagic (DHF, n=29), or an asymptomatic...
The role of human Fcgamma receptors (FcgammaR) has been recognized considerably over the last years. These vary in their affinity for IgG subclasses and intracellular signals elicited by them. Allelic variants FcgammaR genes may influence biological phagocyte activity, accounting an inherited pre-disposition to disease. specific FcgammaRIIa (CD32) contains a polymorphic variant (H/R131) that associated reduced risk developing dengue hemorrhagic fever (DHF). Here, we investigated this...
Background Apoptosis is thought to play a role in the pathogenesis of severe dengue and release cell-free DNA into circulatory system several medical conditions. Therefore, we investigated circulating as potential biomarker for dengue. Methods Findings A direct fluorometric degradation assay using PicoGreen was performed quantify from patient plasma. Circulating levels were significantly higher patients with virus infection than other febrile illnesses healthy controls. Remarkably, increase...
Systematic reviews and/or meta-analyses generally provide the best evidence for medical research. Authors are recommended to use flow diagrams present review process, allowing better understanding among readers. However, no studies as of yet have assessed quality in systematic review/meta-analyses. Our study aims evaluate review/meta-analyses over a period ten years, by assessing diagrams, and correlation methodological quality. Two hundred articles "systematic review" "meta-analysis" from...