A5041133358- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Radiation Detection and Scintillator Technologies
- Radiation Dose and Imaging
- Childhood Cancer Survivors' Quality of Life
- Renal and related cancers
- Medical Imaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Nuclear Physics and Applications
- Advanced MRI Techniques and Applications
- Pediatric Urology and Nephrology Studies
- Radiopharmaceutical Chemistry and Applications
- Testicular diseases and treatments
- Effects of Radiation Exposure
- Quantum Chromodynamics and Particle Interactions
- Diet and metabolism studies
- Optical Systems and Laser Technology
- Neutrino Physics Research
- Graphite, nuclear technology, radiation studies
- Boron Compounds in Chemistry
- Radioactivity and Radon Measurements
- Advanced X-ray and CT Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
University of Tsukuba
2014-2024
University of Tsukuba Hospital
2013-2024
Proton (United Kingdom)
2023
Kyorin University
2016
Kanazawa University
1993
Abstract Retardation of growth and development is a well-known late effect after radiotherapy for pediatric patients. The goal the study was to examine proton beam therapy (PBT) on muscles included in irradiated area. subjects were 17 patients (age ≤ 5 years) who received PBT with treatment field including muscle only one side out pair symmetrical bilateral had imaging evaluations at least 1 year PBT. thicknesses non-irradiated (contralateral) measured retrospectively CT or MRI axial images...
To compare late renal effects in pediatric and adult patients with malignancies after PBT involving part of the kidney. A retrospective study was conducted to assess changes volume function 24 patients, including 12 children (1–14 years old) adults (51–80 old). Kidney volumes were measured from CT or MRI images during follow-up. Dose-volume histograms calculated using a treatment planning system. In children, median for irradiated control kidneys −5.58 (−94.95 +4.79) +14.92 (−19.45 +53.89)...
The purpose of this study was to analyze renal late effects after proton beam therapy (PBT) for pediatric malignant tumors. A retrospective performed in 11 patients under 8 years age who received PBT between 2013 and 2018. kidney exposed irradiation the primary lesion all cases. Kidney volume contour were measured on CT or MRI. Dose calculated with a treatment-planning system. median follow-up 24 months (range, 11–57 months). In irradiated kidneys control contralateral kidneys, changes −5.63...
To investigate the amount that radiation-induced secondary cancer would be reduced by using proton beam therapy (PBT) in place of intensity-modulated X-ray (IMXT) pediatric patients, we analyzed lifetime attributable risk (LAR) as an silico surrogate marker after these treatments. From 242 patients with cancers who were treated PBT, 26 selected random sampling stratification into four categories: (i) brain, head and neck, (ii) thoracic, (iii) abdominal, (iv) whole craniospinal (WCNS)...
Development of a curative local treatment for large hepatocellular carcinoma (HCC) is an important issue. Here, we investigated the dose homogeneity, safety and antitumor effectiveness proton beam therapy (PBT) using patch-field technique HCC. Data from nine patients (aged 52-79 years) with HCC treated PBT were investigated. The cranial-caudal diameters clinical target volumes (CTVs) 15.0-18.6 cm (median 15.9). CTV was divided cranially caudally while both isocenters aligned along axis...
Dose evaluation for out-of-field organs during radiotherapy has gained interest in recent years. A team led by University of Tsukuba is currently implementing a project advancing boron neutron capture therapy (BNCT), along with radiation treatment planning system (RTPS). In this study, the authors used RTPS (the ‘Tsukuba-Plan’) to evaluate dose BNCT. Computed tomography images whole-body phantom were imported into RTPS, and voxel model was constructed Monte Carlo calculations, which Particle...
Abstract In proton therapy, the Bragg peak of a beam reportedly deteriorates when passing though heterogeneous structures such as human lungs. Previous studies have used random voxel phantoms, in which soft tissues and air are randomly allotted to render phantoms same density lungs, for conducting Monte Carlo (MC) simulations. However, measurements these complicated owing their difficult‐to‐manufacture shape. present study, we Voronoi tessellation design phantom that can be manufactured,...
Liquid ionization chambers (LICs) are highly sensitive to dose irradiation and have small perturbations because of their liquid-filled volume. They require a volume much smaller than conventional air-filled chambers. However, it has been reported that the collection efficiency dependencies on per pulse repetition frequency pulsed beam. The purpose this study was evaluate in detail dependency ion frequency. A microLion (PTW, Freiburg, Germany) LIC exposed photon electron beams from TrueBeam...
Background: Our purpose in this study was to clarify whether differences subject group attributes could affect data acquisition proton magnetic resonance spectroscopy ( 1 H-MRS). Methods: Subjects without diabetes mellitus (DM) were divided into two groups (group A, their 20s; B, 30–60 years old). with DM formed C (30–60 The numbers of subjects 19, 27, and 22 for respectively. For all subjects, H-MRS measurements taken the soleus muscle (SOL) anterior tibial (AT). We defined success by...
Abstract Objective To investigate differences in uptake regions between methyl- 11 C-L-methionine positron emission tomography ( C-MET PET) and gadolinium (Gd)-enhanced magnetic resonance imaging (MRI), their impact on dose distribution, including changing of the threshold for tumor boundaries. Methods Twenty consecutive patients with grade 3 or 4 glioma who had recurrence after postoperative radiotherapy (RT) April 2016 October 2017 were examined. The study was performed using simulation...
The linear energy transfer (LET) of proton therapy beams increases rapidly from the Bragg peak to end beam. Although LET can be determined using analytical or computational methods, a technique for efficiently measuring its spatial distribution has not yet been established. Thus, purpose this study is develop measure two-dimensional in real time combination multiple scintillators with different quenching.
This study aims to provide a model that compounds historically proposed ideas regarding cell survival irradiated with X rays or particles. The parameters used in this have simple meanings and are closely related death-related phenomena. is adaptable wide range of doses dose rates thus can consistently explain previously published data. formulas the were derived by using five basic ideas: 1. "Poisson's law"; 2. "DNA affected damage"; 3. "repair"; 4. "clustered 5. "saturation reparability"....
Passive scattering proton beam therapy (PSPT) is performed by taking actual measurements of all pre-designated fields in a treatment plan followed appropriate adjustments to the prescribed dose. For this reason, it necessary ensure precision management (patient-specific calibration) administration planned Therefore, study investigated impact on dose distribution planning when patient calibration point differs from normalized plan.
Purpose: To examine how much lifetime attributable risk (LAR) as an in silico surrogate marker of radiation‐induced secondary cancer would be lowered by using proton beam therapy (PBT) place intensity modulated x‐ray (IMXT) pediatric patients. Methods: From 242 patients with cancers who were treated PBT, 26 selected random sampling after stratification into four categories: a) brain, head, and neck, b) thoracic, c) abdominal, d) whole craniospinal (WCNS) irradiation. IMXT was re‐planned the...
In the accident at Fukushima Daiichi Nuclear Power Plant (NPP) that accompanied Great East Japan Earthquake on 11th of March, 2011, large amounts radionuclides were released into atmosphere. Among these radionuclides, there was an especially amount 131I and 137Cs. Two years have passed since accident, decontamination deposited has become a significant task. present study, quantitative evaluation depth distribution 137Cs in soil using high-purity germanium semiconductor detector performed...
Abstract Introduction Despite the development of DOSIRIS™, an eye lens dosimeter, characteristics DOSIRIS™ in area radiotherapy have not been investigated. The purpose this study was to evaluate basic 3‐mm dose equivalent measuring instrument radiotherapy. Methods Dose linearity and energy dependence were evaluated for irradiation system based on calibration method monitor dosimeter. angle measured by irradiating from a total 18 directions. Interdevice variation repeated three times...
Abstract Objective To investigate differences in uptake regions between methyl- 11 C-L-methionine positron emission tomography ( C-MET PET) and gadolinium (Gd)-enhanced MRI, to examine the effects on dose distribution of changing threshold value for definition tumor boundaries. Methods Twenty consecutive patients with grade 3 or 4 glioma who had recurrence after postoperative RT April 2016 October 2017 were examined study. This study is simulation assuming all received RT. Clinical target...