A5065505348- Chemical synthesis and pharmacological studies
- Cyclopropane Reaction Mechanisms
- Synthesis of heterocyclic compounds
- Head and Neck Cancer Studies
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Pyrroles
- Synthesis and Reactivity of Heterocycles
- Synthesis and Reactions of Organic Compounds
- Synthesis and biological activity
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Tumors and Oncological Cases
- Ear and Head Tumors
- Organic Chemistry Cycloaddition Reactions
- Cleft Lip and Palate Research
- Synthesis of Organic Compounds
- Reconstructive Surgery and Microvascular Techniques
- Bone Tumor Diagnosis and Treatments
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
University of Tsukuba
2016-2025
University of Tsukuba Hospital
2024
Tsukuba University of Technology
2024
Fukuoka University
2008-2018
National Medical Research Center of Dentistry and Maxillofacial Surgery
2011-2013
University of the Ryukyus
2010
Tokyo Medical University
1931-2007
Osaka University
2000-2007
Mito Saiseikai General Hospital
2006
Nippon Medical School
1989-2005
Recently, medical rapid prototyping (MRP) models, fabricated with computer-aided design and manufacture (CAD/CAM) techniques, have been applied to reconstructive surgery in the treatment of head neck cancers. Here, we tested use preoperatively manufactured reconstruction plates, which were produced using MRP models. The clinical efficacy esthetic outcome these products mandibular was evaluated. A series 28 patients malignant oral tumors underwent unilateral segmental resection mandible...
Abnormal miRNA expression was recently implicated in the metastasis of oral squamous cell carcinoma (OSCC) and with a poor prognosis. The initiation invasion-metastasis cascade involves epithelial-mesenchymal transition (EMT). Our aim to clarify how miRNA, especially miR-155-5p misexpression contributes OSCC through EMT.We collected tumor samples from 73 subjects OSCC. were analyzed by quantitative reverse-transcription polymerase chain reaction (qRT-PCR), correlations between levels...
Betacellulin (BTC), a member of the epidermal growth factor family, is expressed predominantly in human pancreas and induces differentiation pancreatic acinar cell line (AR42J) into insulin-secreting cells, suggesting that BTC has physiologically important role endocrine pancreas. In this study, we examined vivo effect recombinant (rhBTC) on glucose intolerance morphology using new mouse model with induced by selective alloxan perfusion. RhBTC (1 microg/g body wt) or saline was injected...
MicroRNAs (miRNAs or miRs) play important roles in carcinogenesis. The miRNA, miR-205-5p, has been reported to suppress the growth of various types tumor; however, its functional contribution oral squamous cell carcinoma (OSCC) is not yet clear. Thus, this study was conducted determine miRNA expression signatures OSCC and investigate role miR‑205‑5p cells. We measured by RT-qPCR, examined function transfecting a mimic inhibitor into cells measuring proliferation, migration invasiveness....
Mesenchymal stem cells (MSC) are multipotent and possess high proliferative activity, thus thought to be a reliable cell source for therapies. Here, we isolated MSC from adult tissues--bone marrow (BM-MSC), dental tissue (DT-MSC), adipose (AT-MSC)--to compare how autotransplantation of these effectively supports the repair bone fracture ischemic tissue. An analysis by in vitro differentiation assays showed no significant difference among MSC. The degree calcification at joint region was...
Abstract magnified image A series of new spiro[cyclopropane‐1,4′‐pyrazol‐3‐one] derivatives 3a‐h were synthesized by the reaction 4‐arylidene‐3 H ‐pyrazol‐3‐one 1 with secondary and tertiary carbanions derived from a methylene methine group bearing both leaving electron‐withdrawing group, e.g. methyl chloroacetate, ethyl isopropyl tert ‐butyl chloroacetonitrile, 2‐chloro‐ N,N ‐diethylacetamide, 2‐chloropropionate 2‐chloropropionitrile, in presence sodium hydride. All compounds active against...
High pulse rate is a culprit of all causes death in the general population, but its relation to haemodialysis (HD) patients has not been examined large patient cohort.We relationship between (beats per minute, bpm) before an HD session and survival based on nationwide registry Japanese Society for Dialysis Therapy. Outcomes were confirmed using coded ID numbers both 2005 2006 registries. Logistic analyses performed determine effect pre-HD survival. A total 147,702 (50.5% men; 31.4% with...
Abstract The systemic inflammatory response is known to be associated with poor outcomes in patients various types of cancer. C-reactive protein (CRP)/albumin (Alb) ratio (CAR) has been reported as a novel inflammation-based prognostic marker. We have evaluated the value markers for oral squamous cell carcinoma (OSCC). study population included 205 treated OSCC between 2013 and 2018. primary predictor variable was markers. outcome overall survival (OS). Univariate multivariate analyses were...
Exercise can be hypothesized to play an important role in non-alcoholic fatty liver disease (NAFLD) treatment by changing the oral bacterial flora and mechanism underlying periodontal disease. We performed salivary component analysis before after exercise regimen, genome of elucidate mechanism. Obese middle-aged men with NAFLD were allocated 12-week (n = 49) or dietary restriction 21) groups. collected saliva compare microflora; predictive metagenomic functions; and, measured immunoglobulin...
Elective neck dissection (END) is recommended for the management of patients with oral squamous cell carcinoma (OSCC) because risk occult metastasis (OM). We hypothesized that some factors predict poor prognosis regardless a cN0 END. This study aimed to investigate predictors OM and prognostic in OSCC who underwent supraomohyoid (SOHND). A retrospective cohort design was created implemented. The primary predictive variables this were after SOHND. Cox proportional hazard model used adjust...
Malononitrile reacts with 2-chloroethanol and 1-chloro-2-propanol (or 2-methyloxirane) in the presence of sodium ethoxide to give 2-amino-3-cyano-4, 5-dihydrofuran (Ia) 2-amino-3-cyano-5-methyl-4, (Ib), respectively. The reaction malononitrile 2-phenyl-oxirane or 2-chloro-1-phenylethanol gave 2-amino-3-cyano-4 (and 5)-phenyl-4, 5-dihydrofurans (Ic Id). 2-benzamido derivatives (IIb-d) Ib-d were aromatized by treatment N-bromosuccinimide corresponding furans (IIIb-d).
Nonalcoholic steatohepatitis (NASH) is one of the leading causes chronic liver disease worldwide. However, details pathogenetic mechanisms remain unknown. Deletion both p62/Sqstm1 and Nrf2 genes spontaneously led to development NASH in mice fed a normal chow was associated with tumorigenesis. The mechanism (s) underlying investigated p62:Nrf2 double-knockout (DKO) mice. DKO showed massive hepatomegaly fat accumulation had hyperphagia-induced obesity coupled insulin resistance adipokine...