A5036554864- Superconducting Materials and Applications
- Particle accelerators and beam dynamics
- Physics of Superconductivity and Magnetism
- Electromagnetic Launch and Propulsion Technology
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Synthesis and biological activity
- Magnetic confinement fusion research
- Spacecraft and Cryogenic Technologies
- interferon and immune responses
- Natural product bioactivities and synthesis
- Bioactive Compounds and Antitumor Agents
- Magnetic Properties and Applications
- HVDC Systems and Fault Protection
- NF-κB Signaling Pathways
- Enzyme Structure and Function
- Biochemical and Molecular Research
- Thermal Analysis in Power Transmission
- Plant biochemistry and biosynthesis
- Cancer therapeutics and mechanisms
- Electric Motor Design and Analysis
- Quinazolinone synthesis and applications
- Synthesis and Biological Evaluation
- Superconductivity in MgB2 and Alloys
- Synthesis and Characterization of Heterocyclic Compounds
Kumamoto University
2015-2025
Murata (Japan)
2023-2025
Tokuyama (Japan)
2025
Saga University
2022-2024
National Institute of Advanced Industrial Science and Technology
1997-2003
Hitachi (Japan)
2002
Electrotechnical Institute
1985-1998
Photonics Electronics Technology Research Association
1995
The Japan Society of Applied Physics
1991-1994
Toshiba (Japan)
1993
Rationale: Respiratory syncytial virus (RSV) induces not only infantile recurrent wheezing but also potentially atopic asthma.Objectives: To test the effect of RSV infection on development subsequent asthma, we evaluated whether palivizumab, an anti-RSV monoclonal antibody, by preventing severe disease in first year life, could impact and asthma at 6 years age.Methods: During 2007 to 2008 season, decision administer palivizumab was made based standard medical practice observational...
X-ray crystallography is a robust and powerful structural biology technique that provides high-resolution atomic structures of biomacromolecules. Scientists use this to unravel mechanistic details biological macromolecules (e.g., proteins, nucleic acids, protein complexes, protein-nucleic acid or large compartments). Since its inception, single-crystal cryocrystallography has never been performed in Türkiye due the lack diffractometer. The diffraction facility recently established at...
Despite the development of antiretroviral therapy against HIV, eradication virus from body, as a means to cure, remains in progress. A "kick and kill" strategy proposes "kick" latent HIV an active eventually be "killed". Latency-reverting agents that can perform function are under have shown promise. Management infected cells not produce virions after step is important this strategy. Here we show newly synthesized compound, L-HIPPO, captures HIV-1 protein Pr55Gag intercepts its translocate...
The discovery of the chimeric tyrosine kinase breakpoint cluster region kinase-Abelson (BCR-ABL)-targeted drug imatinib conceptually changed treatment chronic myelogenous leukemia (CML). However, some CML patients show resistance to imatinib. To address this issue, artificial heterocyclic compounds have been identified as BCR-ABL inhibitors. Here we examined whether plant-derived pentacyclic triterpenoid gypsogenin and/or their derivatives inhibitory activity against BCR-ABL. Among three...
Epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) are crucial targetable enzymes in cancer management. Therefore, herein, new 2-[(5-((1H-indol-3-yl)methyl)-1,3,4-oxadiazol-2-yl)thio]-N-(thiazol/benzothiazol-2-yl)acetamides (2a–i) were designed synthesized as EGFR COX-2 inhibitors. The cytotoxic effects of compounds 2a–i on HCT116 human colorectal carcinoma, A549 lung adenocarcinoma, A375 melanoma cell lines determined using MTT assay....
Glioma, particularly its most malignant form, glioblastoma multiforme (GBM), is the common and aggressive central nervous system tumor. The drawbacks of current chemotherapy for GBM have aroused curiosity in search targeted therapies. Aberrantly overexpressed epidermal growth factor receptor (EGFR) results poor prognosis, low survival rates, responses to therapy recurrence, therefore EGFR-targeted stands out as a promising approach treatment gliomas. In this context, series pentacyclic...
Nuclear factor κB (NF-κB) is activated by various inflammatory and infectious molecules involved in immune responses. It has been elucidated that ADP-β-D-manno-heptose (ADP-Hep), a metabolite gram-negative bacteria, activates NF-κB through alpha-kinase 1 (ALPK1)–TIFA–TRAF6 signaling. ADP-Hep stimulates the kinase activity of ALPK1 for TIFA phosphorylation. Complex formation between phosphorylation-dependent oligomer TRAF6 promotes polyubiquitination activation. TIFAB, homolog lacking...
S-trityl-l-cysteine (STLC) is a well-recognized lead compound known for its anticancer activity owing to potent inhibitory effect on human mitotic kinesin Eg5. STLC contains two free terminal amino and carboxyl groups that play pivotal roles in binding the Eg5 pocket. On other hand, such zwitterion structure complicates clinical development of because solubility issues. Masking either these radicals reduces or abolishes against We recently identified characterized new class nicotinamide...
Abstract Despite various inhibitors targeting the zinc center(s) of enzymes, drugs that target fingers have not been examined in detail. We previously developed a dithiol compound named SN‐1 has an inhibitory effect on function finger transcription factors, but its mechanism action yet elucidated. To establish general principle for new drugs, details against protein were examined. As zinc‐finger‐containing protein, we focused TRAF6, which is related to cancer and inflammation. Binding TRAF6...
Colorectal cancer (CRC) and breast are leading causes of death globally, due to significant challenges in detection management. The late-stage diagnosis treatment failures require the discovery potential anticancer agents achieve a satisfactory therapeutic effect. We have previously reported series plastoquinone analogues understand their cytotoxic profile. Among these derivatives, three them (AQ-11, AQ-12, AQ-15) were selected by National Cancer Institute (NCI) evaluate vitro...
Lipid-coupled inositol 1,2,3,4,5,6-hexakisphosphate binds to HIV-1 MA tightly through both electrostatic and hydrophobic interactions.
Despite the development of a range anti-cancer agents, cancer diagnoses are still increasing in number, remaining leading cause death. Anticancer drug treatment is particularly important for leukemia. We screened Turkish plants and found unique antileukemic activity twig components Caucasian beech, selectively inducing apoptosis leukemia cells. This effect among some kinds beeches, presumably related to oxidative stress. study would lead effective use discarded material, i.e., new...