Günseli Yıldırım
A5085732158- Enzyme Structure and Function
- HIV/AIDS drug development and treatment
- Protein Structure and Dynamics
- Biochemical and Molecular Research
- HIV Research and Treatment
- Education Practices and Challenges
- Computational Drug Discovery Methods
- Resilience and Mental Health
- Problem Solving Skills Development
- Teacher Professional Development and Motivation
- Biotin and Related Studies
- 14-3-3 protein interactions
- thermodynamics and calorimetric analyses
- Force Microscopy Techniques and Applications
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Health and Well-being Studies
- Porphyrin Metabolism and Disorders
- Mechanical Engineering and Vibrations Research
- Microtubule and mitosis dynamics
- Families in Therapy and Culture
- Amyotrophic Lateral Sclerosis Research
- Vitamin C and Antioxidants Research
- Prion Diseases and Protein Misfolding
- Educational Methods and Analysis
VIB-KU Leuven Center for Brain & Disease Research
2025
Koç University
2020-2023
SLAC National Accelerator Laboratory
2021
The COVID-19 pandemic has resulted in 198 million reported infections and more than 4 deaths as of July 2021 (covid19.who.int). Research to identify effective therapies for includes: (1) designing a vaccine future protection; (2) de novo drug discovery; (3) identifying existing drugs repurpose them immediate treatments. To assist repurposing design, we determine two apo structures severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease at ambient temperature by serial...
X-ray crystallography is a robust and powerful structural biology technique that provides high-resolution atomic structures of biomacromolecules. Scientists use this to unravel mechanistic details biological macromolecules (e.g., proteins, nucleic acids, protein complexes, protein-nucleic acid or large compartments). Since its inception, single-crystal cryocrystallography has never been performed in Türkiye due the lack diffractometer. The diffraction facility recently established at...
Cytoplasmic aggregation and nuclear depletion of TAR DNA-binding protein 43 (TDP-43) are hallmarks several neurodegenerative disorders. Yet, recapitulating both features in cellular systems has been challenging. Here, we produced amyloid-like fibrils from recombinant TDP-43 low-complexity domain demonstrate that sonicated trigger pathology human cells, including induced pluripotent stem cell (iPSC)-derived neurons. Fibril-induced cytoplasmic inclusions acquire distinct biophysical...
Objective: The aim of the study is to carry out adaptation Secondary Traumatic Stress Scale Turkish and seek evidence validity reliability scale. Methods: was conducted with a total 334 health professionals, ranging in age from 17 64 years seniority 1 33 years. Of participants, 197 (59%) were female, 137 (41%) male. psychiatry, emergency intensive care services outpatient clinics Izmir Tepecik Training Research Hospital. 103 participants physicians, 188 nurses, 21 medical technicians, 22...
Abstract Multimeric protein assemblies are abundant in nature. Streptavidin is an attractive that provides a paradigm system to investigate the intra- and intermolecular interactions of multimeric complexes. Also, it offers versatile tool for biotechnological applications. Here, we present two apo-streptavidin structures, first one ambient temperature Serial Femtosecond X-ray crystal (Apo-SFX) structure at 1.7 Å resolution second cryogenic (Apo-Cryo) 1.1 resolution. These structures mostly...
Oligomerization of Pr55
Abstract X-ray crystallography is a robust and powerful structural biology technique that provides high-resolution atomic structures of biomacromolecules. Scientists use this to unravel mechanistic details biological macromolecules (e.g. proteins, nucleic acids, protein complexes, protein-nucleic acid or large compartments). Since its inception, single-crystal cryo-crystallography has never been performed in Türkiye due the lack diffractometer. The diffraction facility recently established...
Abstract The COVID19 pandemic has resulted in 25+ million reported infections and nearly 850.000 deaths. Research to identify effective therapies for includes: i) designing a vaccine as future protection; ii) structure-based drug design; iii) identifying existing drugs repurpose them immediate treatments. To assist repurposing design, we determined two apo structures of Severe Acute Respiratory Syndrome CoronaVirus-2 main protease at ambienttemperature by Serial Femtosecond X-ray...
ABSTRACT Multimeric protein assemblies are abundant in nature. Streptavidin is an attractive that provides a paradigm system to investigate the intra- and intermolecular interactions of multimeric complexes. Also, it offers versatile tool for biotechnological applications. Here, we present two apo-streptavidin structures, first one ambient temperature Serial Femtosecond X-ray crystal (Apo-SFX) structure at 1.7 Å resolution second cryogenic (Apo-Cryo) 1.1 resolution. These structures mostly...
ABSTRACT HIV-1 continues to be a global health concern since AIDS was first recognized by the World Health Organization (WHO). It is estimated that there were 38 million people infected with and 1.5 deaths in 2019 alone. A better understanding of details HIV late-stage life cycle, involving Pr55 Gag attachment membrane for further oligomerization release virion, will provide us new avenues potential treatment. Inositol hexakisphosphate (IP6) an abundant endogenous cyclitol molecule its...
Abstract HIV-1 continues to be a global health concern since AIDS was first recognized by the World Health Organization (WHO). It is estimated that there were 38 million people infected with and 1.5 deaths in 2019 alone. A better understanding of details HIV late-stage life cycle, involving Pr55 Gag attachment membrane for further oligomerization release virion, will provide us new avenues potential treatment. Inositol hexakisphosphate (IP6) an abundant endogenous cyclitol molecule its...