A5055741683- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Alcohol Consumption and Health Effects
- Systemic Lupus Erythematosus Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Drug-Induced Hepatotoxicity and Protection
- Gallbladder and Bile Duct Disorders
- Abdominal Trauma and Injuries
- Cancer Mechanisms and Therapy
- Organ Transplantation Techniques and Outcomes
- Cancer, Hypoxia, and Metabolism
- Abdominal vascular conditions and treatments
- Neuroendocrine Tumor Research Advances
- Hepatitis Viruses Studies and Epidemiology
- Gastroesophageal reflux and treatments
- Metabolomics and Mass Spectrometry Studies
- Metabolism and Genetic Disorders
- Pharmacy and Medical Practices
- Renal cell carcinoma treatment
- Parvovirus B19 Infection Studies
- Pancreatitis Pathology and Treatment
Kitasato University
2013-2022
Kitasato University Hospital
2006-2022
The Japanese Society of Gastroenterological Surgery
2016
Kitasato University East Hospital
2002-2014
Nagoya University
2013
Cellular Research (United States)
1995
Beckman Research Institute
1988-1992
City of Hope
1988-1992
National Sagamihara Hospital
1992
Kanto Chemical (Japan)
1988
To identify the determinants of tumor progression, we examined ablation zones and patterns local progression small single primary hepatocellular carcinomas after radiofrequency ablation.Eighty-five patients with carcinoma less than 3 cm in diameter underwent complete ablation. Clinical biochemical features, characteristics, location within 5 mm from intrahepatic vessels, needle biopsy before treatment, presence ablative margin or more were statistically analyzed as progression. The...
Expression cloning of cDNAs was first described a decade ago and based on transient expression cDNA libraries in COS cells. In contrast to transfection plasmids, retroviral gene transfer delivers genes stably into wide range target We utilize simple packaging system for production high-titer retrovirus stock from establish system. two model experiments, murine interleukin (IL)-3-dependent Ba/F3 cells were infected with retrovirally expressed derived human T-cell mRNA or IL-3-dependent TF-1...
This study investigated the survival benefits of sorafenib vs. radiotherapy (RT) in patients with unresectable hepatocellular carcinoma (HCC) and portal vein tumor thrombosis (PVTT) main trunk or first branch. Ninety-seven were retrospectively reviewed. Forty enrolled by Kanagawa Liver Study Group received sorafenib, 57 consecutive RT our hospital. Overall was compared between two groups PVTT propensity score (PS) analysis. Factors associated evaluated multivariate The median treatment...
To determine the value of early alterations tumor markers α-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) for predicting outcomes patients with advanced hepatocellular carcinoma (HCC) who receive sorafenib.Tumor response, overall survival (OS), progression-free (PFS) were retrospectively analyzed in 59 HCC. Serum AFP DCP examined elevation within 4 weeks after initiation sorafenib. An increase was defined as more than 20%, an two-fold higher level baseline. The relationship clinical...
The incidence of hepatocellular carcinoma (HCC) in patients with primary biliary cirrhosis (PBC) is not well known. aims this study are to determine HCC and survival, identify risk factors associated these outcomes PBC. We collected information on 396 PBC at enrollment followed-up from 6 271 months. They were all negative for hepatitis B C virus markers. was detected by scanning ultrasonography, computed tomography, or both every 4 Life expectancy (LE) approximated the declining exponential...
OBJECTIVE To study an autopsy case of troglitazone-induced fulminant hepatitis. CASE REPORT A 58-year-old man contracted severe hepatitis 2 months after administration troglitazone for the treatment type diabetes. Liver damage progressed gradually, even withdrawal agent. Despite intensive therapy, became and patient died 8 weeks onset liver damage. Autopsy revealed massive hepatic necrosis cholestasis with inflammatory cell infiltration. The pathological findings positive result drug-induced...
Aim: Sorafenib is approved for the treatment of advanced hepatocellular carcinoma (HCC) in Japan; however, its tolerability and efficacy elderly patients with HCC have not been clarified. We aimed to evaluate sorafenib increasing age. Methods: As part a retrospective, multicenter cohort study conducted between May 2009 February 2010, received 400 mg twice daily (standard dosage) or once (half‐dosage) until disease progression intolerance. Results: The mean age enrolled ( n = 76) was 70.3...
Scirrhous hepatocellular carcinoma (SHCC) is a rare variation of HCC, for which characteristics tumor cells and the fibrotic stroma have not been clarified in detail. The present study was therefore carried out to elucidate cytological features stromal components extracellular matrix 15 SHCC patients undergoing hepatectomy without preoperative transarterial embolization. Diagnosis on basis scirrhous histological pattern exceeding 50% area. Expression cytoplasmic proteins compared among SHCC,...
An aldehyde dehydrogenase isozyme, ALDH3, which is strongly expressed in the stomach, may play a role oxidation of toxic aldehydes. Using reverse genetic approach, we cloned and characterized cDNA gene for ALDH3. The full length 1624 base pairs (bp) contains an open reading frame encoding 453 amino acid residues. deduced sequence shows high degree resemblance to that rat hepatocarcinoma ALDH. human ALDH3 spans about 8 kb consists 10 exons. putative TATA CCAAT boxes are located consensus...
Although hepatitis B virus (HBV) DNA can be detected in liver or sera of patients without serum surface antigen (HBsAg), its clinical relevance hepatocarcinogenesis remains controversial. This observational cohort study was conducted to clarify the risk factors, including presence HBV and core antibody (anti-HBc), for hepatocellular carcinoma (HCC) with C (HCV)-related cirrhosis (LC).The comprised 123 LC due HCV, negative HBsAg. The factors HCC development were analyzed by univariate...
Recent studies have suggested that an occult hepatitis B virus (HBV) infection negative for HBsAg but positive HBV-DNA contributes to hepatocellular carcinoma (HCC) development in patients with chronic C. Some follow-up the clinical importance of HBV infections HCC even after interferon (IFN) therapy, a recent study denies significance impact infection. Focusing on whom C (HCV) eradication by therapy had failed, we conducted this order assess these patients.We enrolled 141 (histological...
Intrahepatic distant recurrence (IDR) of hepatocellular carcinoma (HCC) after curative treatment occurs frequently and influences the prognoses. The aim this study was to determine prognostic factors affecting survival IDR optimum therapy for IDR.A total 115 patients with a single small primary HCC who had complete radiofrequency (RF) ablation were enrolled in study. statistically analyzed among IDRs.IDRs observed 59 (51.3%) median observation period 19.6 months. cumulative rates IDRs 11.8,...
Diaphragmatic Hernia After Radiofrequency Ablation Therapy for Hepatocellular CarcinomaAkitaka Shibuya1, Takahide Nakazawa1, Katsunori Saigenji1, Kazunori Furuta2 and Keiji Matsunaga3Audio Available | Share
To examine the efficacy and outcomes of radiotherapy (RT) in patients who have hepatocellular carcinoma with invasion to intrahepatic large vessels (IHLVs).Sixty-seven had advanced IHLVs received three-dimensional conformal RT. IHLV was associated portal venous tumor thrombosis 40 patients, involving hepatic vein 17, both findings 10. A daily radiation dose 1.8-2 Gy administered using 6 or 10 MV X-rays deliver a total 30-56 Gy.The overall objective response rate (complete plus partial...
<i>Objectives:</i> To examine the efficacy and prognostic benefits of radiotherapy (RT) in patients who have unresectable advanced hepatocellular carcinoma (HCC) with invasion to intrahepatic large vessels (IHLVs). <i>Methods:</i> Sixty-eight had HCC IHLVs were studied. Thirty-two consecutive initially received 3-dimensional conformal RT for IHLVs. Tumor response, factors, survival studied given RT. Prognostic factors assessed study group as a whole. Data analyzed...