A5057809960- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Salivary Gland Tumors Diagnosis and Treatment
- Tracheal and airway disorders
- Voice and Speech Disorders
- Advanced Data Compression Techniques
- Dysphagia Assessment and Management
- Ear and Head Tumors
- Advanced Memory and Neural Computing
- Cancer Diagnosis and Treatment
- Esophageal and GI Pathology
- Head and Neck Anomalies
- Image and Signal Denoising Methods
- Platelet Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Ultrasound Imaging and Elastography
- Ultrasound and Hyperthermia Applications
- Oral and Maxillofacial Pathology
- Lung Cancer Diagnosis and Treatment
- Oral health in cancer treatment
- Advanced Steganography and Watermarking Techniques
- Thyroid and Parathyroid Surgery
- Airway Management and Intubation Techniques
- Transition Metal Oxide Nanomaterials
- Video Coding and Compression Technologies
Tottori University
2015-2024
Shionogi (Japan)
2018-2023
Tottori University Hospital
2012-2021
MSD K.K. (Japan)
2018
Facial Plastics Surgery Associates
2017
Sony (Taiwan)
2008-2015
Okayama University
2015
Takushoku University
2015
Sony Corporation (United States)
1999-2013
Kitami Institute of Technology
2011-2012
This multicenter, double-blind, phase 2a part of a 2/3 study assessed the efficacy and safety ensitrelvir, novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3C-like protease inhibitor, in Japanese patients with mild-to-moderate disease 2019 (COVID-19) or asymptomatic SARS-CoV-2 infection. Sixty-nine were randomized (1:1:1) to orally receive 5-day ensitrelvir fumaric acid (375 mg on day 1 followed by 125 daily, 750 250 daily) placebo up until 28.
Background & AimsPlatelet transfusion is used to prevent hemorrhagic events in patients with thrombocytopenia undergoing invasive procedures, but there are many disadvantages. We evaluated the efficacy and safety of lusutrombopag chronic liver disease procedures.MethodsWe performed a double-blind, parallel-group, phase 3 study 96 (platelet counts below 50,000/μL) procedures from October 2013 May 2014 at 81 centers Japan. Patients were randomly assigned (1:1) groups given once-daily (3 mg) or...
Ensitrelvir is a novel selective inhibitor of the 3C-like protease SARS-CoV-2, which essential for viral replication. This phase 1 study ensitrelvir assessed its safety, tolerability, and pharmacokinetics single (part 1, n = 50) multiple 2, 33) ascending oral doses. Effect food on ensitrelvir, differences in between Japanese white participants, effect midazolam (a cytochrome P450 3A [CYP3A] substrate) were also assessed. In part participants randomized to placebo or at doses 20, 70, 250,...
Management of drug–drug interactions (DDIs) for ensitrelvir, a novel 3-chymotrypsin-like protease inhibitor SARS-CoV-2 infection is crucial. A previous clinical DDI study ensitrelvir with midazolam, index cytochrome P450 (CYP) 3A substrate, demonstrated that given 5 days orally loading/maintenance dose 750/250 mg acted as strong CYP3A inhibitor. The objectives this were to investigate the effect on pharmacokinetics substrates, dexamethasone, prednisolone and assess pharmacokinetics, safety,...
Thrombocytopenia represents an obstacle for invasive procedures in chronic liver disease (CLD) patients. We aimed to estimate the appropriate dose and evaluate efficacy safety of lusutrombopag treatment thrombocytopenia before percutaneous radiofrequency ablation (RFA) primary hepatic cancer patients with CLD.In this multicenter, randomized, double-blind, placebo-controlled study conducted Japan, 61 CLD platelet count < 50 × 103/µL at screening were randomized placebo or 2, 3, 4 mg once...
A new Encryption-then-Compression (ETC) system for the JPEG 2000 standard is proposed in this paper. An ETC known as a that makes image communication secure and efficient by using perceptual encryption compression. The uses sign-scrambling block-shuffling of discrete wavelet transform (DWT) coefficients encryption. Unlike conventional systems, compatible with because perceptually encrypted can be efficiently compressed 2000. experimental results demonstrated achieved both acceptable...
Drug-drug interaction potentials of ensitrelvir, a novel oral inhibitor 3C-like protease severe acute respiratory syndrome coronavirus 2, for drug transporters were evaluated by in vitro and clinical studies. The target assessed P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), organic anion transporting polypeptide (OATP) 1B1, OATP1B3, transporter (OAT) 1, OAT3, cation (OCT) OCT2, multidrug toxin extrusion 1 2K. In study revealed that ensitrelvir is substrate P-gp BCRP...
The aims of this study were to evaluate the utility shear wave elastography (SWE) using acoustic radiation force impulse (ARFI) for diagnosing chronic autoimmune thyroiditis (CAT) and verify effect fibrotic thyroid tissue on velocity (SWV). subjects 229 patients with 253 normal lobes (controls) 150 CAT lobes. SWV (2.47 ± 0.57 m/s) was significantly higher than that controls (1.59 0.41 (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Abstract Background Ultrasonography is a non‐invasive technique that commonly used by endocrinologists and endocrine surgeons to examine the thyroid region could be useful for assessment of vocal cord movement these specialists. However, previous studies reported low rate successful visualization ultrasonography. To address this issue, we devised novel ultrasonographic procedure assessing indirectly observing arytenoid from lateral view. Methods Subjects were 188 individuals, including 23...
Lenvatinib is an oral multitargeted tyrosine kinase inhibitor that has anticancer action in patients with differentiated thyroid cancer refractory to radioiodine. Knowledge of the efficacy and safety lenvatinib anaplastic (ATC) limited. Tyrosine inhibitors frequently cause hypothyroidism, but incidence hypothyroidism unclear.We conducted a retrospective study investigate ATC.Five unresectable ATC were enrolled. 24 mg once daily was administered until disease progression, unmanageable...
A reported clinical pharmacokinetics and safety study of suspension formulation ensitrelvir, a therapeutic agent used in severe acute respiratory syndrome coronavirus 2 infection, demonstrated favorable was well tolerated healthy male Japanese White participants. Understanding the pharmacokinetic features ensitrelvir (using approved for use) various populations, effect food, is crucial optimal use.The objectives this were to (1) assess safety, tolerability, following multiple-dose...
Shear wave elastography (SWE) using acoustic radiation force impulse (ARFI) is a novel ultrasonography technique. The aim of this study was to investigate the clinical usefulness quantitative SWE for differentiating thyroid nodules. For phantom study, we measured shear velocities (SWVs) four spheres 2- and 1-cm diameters with varying hardness. SWVs normal glands nodules, that were classified as benign or malignant according either cytological pathological findings, measured. each patient...
Introduction: Near-infrared photoimmunotherapy (NIR-PIT) is a recently developed hybrid cancer therapy that directly kills cells while producing therapeutic host anticancer immune response. The activation of immunity using NIR-PIT can enhance the effects checkpoint inhibitors (ICIs) in animal experimental models; however, there have been no reports this phenomenon humans. Furthermore, by activating patients who become resistant to ICIs, ICIs be restored. Case Presentation: A 56-year-old male...
Parkinson's disease (PD) is associated with a high incidence of dysphagia. Aspiration pneumonia due to dysphagia major cause death in patients PD, and therefore accurately evaluating should help improve prognosis. It has been reported that the severity does not always correlate Hoehn Yahr (H&Y) stage for classifying PD severity. However, no reports have quantitatively evaluated relationship between H&Y stage. High-resolution pharyngeal manometry (HRPM) quantitative method can be used measure...
Tazobactam/ceftolozane, a novel antimicrobial therapy, is active against Pseudomonas aeruginosa and most extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. We report the results of efficacy safety tazobactam/ceftolozane in Japanese patients with complicated intra-abdominal infections (cIAI).A multicenter, open-label, noncomparative study (MK-7625A Protocol 013, ClinicalTrials.gov Identifier: NCT02739997) to investigate used combination metronidazole cIAI was conducted. One...
Transoral robotic surgery (TORS) with the da Vinci Surgical System has been used for removal of pharyngeal and laryngeal cancers objective to improve functional aesthetic outcomes without worsening survival. While TORS approved in many countries, Japan's FDA not yet done so. Our hospital started using approval Ethical Review Board Minimum Invasive Center Committee at Tottori University. No surgical Japanese patients head neck cancer have reported Japan. This paper deals feasibility our...
The reflex cough test is useful for detecting silent aspiration, a risk factor aspiration pneumonia. However, assessing the of pneumonia requires measuring not only but also strength. Currently, no testing device available that can directly measure We therefore developed new easily and simultaneously strength time until reflex, verified whether screening with this instrument feasible evaluating This consists special pipe double lumen, nebulizer, an electronic spirometer. used solution...
Primary squamous cell carcinoma (SCC) in the thyroid is extremely rare and has been reported &#x3c; 1% of all cancer cases. SCC was thought to be a transitional form derived from adenocarcinomas; therefore, majority cases have focused on conjunction with other histological adenocarcinomas. A 73-year-old male presented our hospital bilateral vocal fold palsy an anterior neck mass. Ultrasound sonography revealed bulky tumor cervical lymphadenopathy. We performed fine-needle aspiration...
The pituitary homeobox 1 (PITX1) protein is essential for developmental processes in humans. Previously, PITX1 was identified as a possible tumor suppressor gene various types of human carcinoma. However, the association between and head neck squamous cell carcinoma (HNSCC) remains to be elucidated. Immunohistochemical analysis performed examine expression levels 47 cases HNSCC, 4 control cases. p53 also examined these labeling indices (LIs) were calculated, correlations clinical factors...
This paper presents what is going on in Motion-JPEG2000 standardization and its target applications. In this paper, unique features of introduced from many perspectives such as application market, comparison with other standards, requirements, compression performance compared Motion JPEG file format. Since guarantees backward compatibility JPEG-2000 part-1 the market expected to match.
Background Ultrasonographic homogeneity is an important differential finding between Warthin tumor and pleomorphic adenoma, two types of benign parotid gland tumors, with the former likely to be heterogeneous latter homogeneous. However, differences in performance ultrasound machines or cut-off level affect judgment ultrasonographic homogeneity. Therefore, this study, we adopted a novel system for classifying composition tumors via ultrasonography, using anechoic area as substitute...