A5011615846- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related Molecular Pathways
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Ultrasound and Hyperthermia Applications
- Gallbladder and Bile Duct Disorders
- Gastrointestinal Tumor Research and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- RNA modifications and cancer
- Breast Lesions and Carcinomas
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Neuroendocrine Tumor Research Advances
- Oral and Maxillofacial Pathology
- Liver Disease and Transplantation
- Metastasis and carcinoma case studies
- Inflammasome and immune disorders
- Breast Cancer Treatment Studies
- Abdominal vascular conditions and treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Gastrointestinal disorders and treatments
- Microbial Inactivation Methods
Tottori Prefectural Central Hospital
2020-2023
Kindai University
2014-2022
Nara Medical University Hospital
2020-2022
Tottori University
2010-2020
Hyogo Medical University
2019
Tottori University Hospital
2010-2019
Japan Society
2019
Nagoya University Hospital
2007
We surveyed multiple centers to identify types and frequency of complications mortality rate associated with radiofrequency ablation (RFA) hepatocellular carcinoma (HCC). distributed a questionnaire developed by members the Chugoku-Shikoku Society for Local Ablation Therapy Hepatocellular Carcinoma 20 analyzed rate. In total, 16 346 nodules were treated in 13 283 patients between January 1999 November 2010. Five (0.038%) died: two from intraperitoneal hemorrhage, one each hemothorax, severe...
Background. The microwave tissue coagulator (2450 MHz) has been used clinically in the treatment of hepatocellular carcinoma (HCC) to transection liver parenchyma and proven an excellent method for hemostasis. There are, however, few reports on application this induction tumor necrosis. Methods. Microwave coagulation (MTC) was applied at laparotomy eight patients with nonresectable multiple HCCs. All were treated a combination resection or intrahepato-arterial chemotherapy MTC. A total 222...
Suppression of apoptosis is important for carcinogenesis and tumor growth. Recent studies revealed that survivin not only inhibited but also accelerated cancer cell proliferative activity. To investigate the prognostic role expression antiapoptosis gene, survivin, in hepatocellular carcinoma (HCC), authors analyzed correlation between pattern messenger RNA (mRNA) clinicopathologic findings patients. Tissues were obtained by surgical resection livers from 51 patients with HCC 6 without HCC....
Abstract Purpose: We previously reported the usefulness of a qualified highly sensitive detection method for human telomerase reverse transcriptase (hTERT) mRNA in serum with 89.7% sensitivity hepatocellular carcinoma (HCC). In this study, we developed quantitative hTERT and examined clinical significance HCC diagnosis. Experimental Background: 64 patients HCC, 20 liver cirrhosis, chronic hepatitis, 50 healthy individuals, measured by using newly real-time transcription-PCR SYBR Green I. its...
We examined the relationship between spatial extent of invasion gastric serosa in patients with carcinoma and their postoperative 5-year survival rate. At time surgical resection cancer, intraperitoneal free cancer cells were detected by lavage Douglas cavity 135 309 (44%) gross evidence serosal invasion. Examination presence area invaded tumor revealed that only 22% cases an 10 cm2 or less positive for cells, but such found 72% greater than 20 cm2. The rate was 31% cm2, whereas 8% Not a...
The results of several epidemiological studies have shown a moderate association between postpartum depression (PPD) and mother-infant bonding (MIB); however, associations changes that longitudinally considered parity were not reported. We investigated the possible PPD MIB at one month after birth, in addition, these indices by parity. From dataset comprising 103,099 maternal registrations Japan Environment Children's Study, present study analyzed complete data on questionnaires for 76,363...
Manganese (Mn) is both an essential element and a potential toxicant. Although few studies have suggested nonlinear relationship between the maternal whole blood Mn level at delivery infant birth weight, little known about effects of levels during pregnancy on fetal growth, particularly with regard to sex-specific differences. In this nationwide cohort study, we examined association length, head circumference in 16,473 mother–infant pairs. Pregnant women living 15 regions across Japan were...
Background Interleukin (IL)-18 is markedly elevated in systemic inflammatory diseases that cause the ‘cytokine storm’ such as adult-onset Still’s disease (AOSD) and hemophagocytic lymphohistiocytosis (HLH). The differences IL-18 between AOSD HLH, especially adults, uncertain. Macrophage activation syndrome (MAS), a form of secondary often difficult to differentiate cases include MAS from other HLH. In this case-control study, we investigated whether serum levels could be useful biomarker for...
The suppression of apoptosis is an important factor in tumor progression hepatocellular carcinoma (HCC). However, to the authors knowledge clinicopathologic importance expression apoptosis-related genes (bcl-2, bax, and survivin) HCC remains unclear. In current study, investigated correlation between occurrence spontaneous HCC. addition, prognostic significance patients with was analyzed.Tissue samples were obtained through surgical resection liver 53 5 without levels bcl-2, survivin,...
The results of several epidemiological studies and clinical trials investigating the effects n-3 polyunsaturated fatty acids (PUFAs) on antenatal postnatal depression remain controversial. We investigated possible association dietary intake fish PUFAs with risks maternal paternal psychological distress during pregnancy postpartum in Japan. From a dataset comprising 104,102 registrations 52,426 Japan Environment Children's Study, this study analyzed complete data questionnaires for 75,139,...
Reactive oxygen species may be involved in the progression of chronic liver disease and occurrence hepatocellular carcinoma (HCC). To clarify whether clinicopathological findings diseases are related to oxidative DNA damage, hepatic expression 8-hydroxy-2'-deoxyguanosine (8-OHdG) was examined 75 patients, which included 32 hepatitis (CH), 13 cirrhosis (LC) 30 HCC patients. The CH patients had higher 8-OHdG-positive hepatocytes than LC (P < 0.05). In LC, number correlated with alanine...
Nephrotoxicity is a frequent complication of cisplatin-induced chemotherapy, in which T cells are known to promote acute kidney injury (AKI). Apoptosis and necrosis tubules inflammatory events also contribute the nephrotoxicity. A delineation mechanisms that underlie inappropriate renal tubular inflammation can thus provide important insights into potential therapies for AKI. Rho-kinases act as molecular switches controlling several critical cellular functions, including cell migration,...
We report the case of a patient who developed antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) after receiving coronavirus disease 2019 (COVID-19) vaccine BNT162b (Pfizer–BioNTech). A 37-year-old Japanese woman had been taking propylthiouracil for Graves’ disease. She erythema on her forearm 12th day first dose vaccine, fever 13th day, and redness swelling left auricle 25th day. Her serum myeloperoxidase-ANCA proteinase 3-ANCA levels, which were negative before...
The aim of the present study is to evaluate whether interferon alpha (IFNalpha) therapy can inhibit intrahepatic recurrence after curative treatment small HCC with underlying chronic hepatitis C. Forty patients were enrolled in this study. They had solitary, HCC</=3 cm diameter, C, and </=70 years old. Of patients, 18 treated IFNalpha for 6 months HCC, 22 who did not receive used as controls. Six (33%) IFN group showed sustained response. incidence local was different non-IFN groups (6 vs....
We previously reported a highly sensitive method for serum human telomerase reverse transcriptase (hTERT) mRNA hepatocellular carcinoma (HCC). α-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) are good markers HCC. In this study, we verified the significance of hTERTmRNA in large scale multi-centered trial, collating quantified values with clinical course. 638 subjects including 303 patients HCC, 89 chronic hepatitis (CH), 45 liver cirrhosis (LC) 201 healthy individuals, using...