A5007291063- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Asthma and respiratory diseases
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- IL-33, ST2, and ILC Pathways
- Galectins and Cancer Biology
- Lung Cancer Diagnosis and Treatment
- Esophageal and GI Pathology
- MicroRNA in disease regulation
- Colorectal and Anal Carcinomas
- Retinoids in leukemia and cellular processes
- Helicobacter pylori-related gastroenterology studies
- Mycobacterium research and diagnosis
- Respiratory and Cough-Related Research
- Sarcoma Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer-related molecular mechanisms research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Eosinophilic Esophagitis
- Circular RNAs in diseases
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Tuberculosis
- Immunotherapy and Immune Responses
Kyoto Prefectural University of Medicine
2011-2025
Tottori University
2013-2025
Kubota (Japan)
2020
University of Yamanashi Hospital
2019
Kawasaki Medical School
2008-2017
University Health Network
2015
Kyoto first Red Cross hospital
2009-2011
Funabashi Orthopaedic Hospital
2002
Humboldt-Universität zu Berlin
1998
To improve the outcome of cancer chemotherapy, strategies to enhance efficacy anticancer drugs are required. Sorafenib is only drug prolong overall survival patients with hepatocellular carcinoma (HCC), however, still not satisfactory. Retinoids, vitamin A derivatives, have been known exhibit inhibitory effects on various cancers including HCC. In this study, we investigated combined treatment using sorafenib and retinoids all-trans retinoic acid (ATRA), NIK-333, Am80 HCC cells. Cell...
Activation of hepatic stellate cells (HSCs) is the effector factor fibrosis and hepatocellular carcinoma (HCC) development. Accumulating evidence suggests that retinoic acids (RAs), derivatives vitamin A, contribute to prevention liver carcinogenesis, however, regulatory mechanisms RAs still remain exclusive. To elucidate RA signaling pathway, we previously performed a genome‐wide screening RA‐responsive genes by in silico analysis RA‐response elements, identified 26 genes. We found...
Galectin-9 (Gal-9) is a β-galactoside-binding protein involved in various biologic processes, including cell aggregation, adhesion, chemoattraction, and apoptosis. Little known, however, about the regulation mechanisms of Gal-9 production. Recent studies reported high plasma levels humans infected with human immunodeficiency virus-1 dengue virus. Viral respiratory infections such as influenza are common illnesses. A synthetic double-stranded RNA, polyinosinic-polycytidylic acid (PolyIC),...
Predicting the prognosis and adverse events (AEs) of nivolumab therapy for recurrent esophageal cancer is very important. The present study investigated whether a simple blood biochemical examination could be used to predict AEs following treatment relapse cancer. A total 41 patients who received after esophagectomy were analyzed. absolute lymphocyte count (ALC), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte (PLR), monocyte-lymphocyte (MLR) C-reactive protein-albumin (CAR) assessed...
Recent studies identified that SH3 and multiple ankyrin repeat domains 2 (SHANK2) is located in a gene-amplified region 11q13 of various human cancers, has oncogenic functions as Hippo pathway suppressor hepatocellular carcinoma. In this study, we tested whether SHANK2 acts cancer-promoting gene through its activation or overexpression gastric cancer (GC). We analyzed 5 GC cell lines 172 primary tumor samples GC, which were curatively resected our hospital. Overexpression protein was...
The optimal extent of lymph node dissection in colon cancer surgery is specified guidelines based on the results past analyses. However, with advances surgical techniques and multidisciplinary treatments, clinical significance dissecting each may change. In this study, we re-examined range localization. We retrospectively analyzed 788 cases T1–T4 who underwent radical resection between 2008 2018 at our hospital, evaluated Lymphadenectomy Index. No metastases to main were found T1 cases. T2...
Abstract Aim The epidemiology of hemorrhoids is challenging because variability in sampling methodologies and diagnostic criteria across different studies. This study indirectly clarified the by investigating number invasive treatments for (ITH) using a nationwide healthcare claims database. Methods annual rate ITH procedures per 100 000 people during 2018–2022 were examined. covered Japanese insurance includes sclerotherapy, rubber band ligation, infrared coagulation, thrombectomy,...
Through the use of QuantiFERON-TB Gold, a commercial IFN-γ assay, we compared differences in quantitative T-cell responses to Mycobacterium tuberculosis (MTB)-specific antigens [QuantiFERON TB-2G (QFT-2G)] between patients with active (TB) disease and those latent TB infection (LTBI). The patient group consisted 180 (culture-positive for MTB) 50 screening contacts LTBI-positive response QFT-2G test. We prospectively performed tuberculin skin test (TST) all subjects. median levels upon...
CD44 is a cell adhesion molecule involved in lymphocyte infiltration of inflamed tissues. We previously demonstrated that plays an important role the development airway inflammation murine model allergic asthma. In this study, we investigated expressed on CD4(+) T cells accumulation T-helper type 2 (Th2) using CD44-deficient mice and anti-CD44 monoclonal antibodies. Antigen-induced Th2-mediated hyperresponsiveness (AHR) sensitized were reduced by CD44-deficiency. These asthmatic responses...
To evaluate the clinical utility of T-SPOT.TB test for patients with indeterminate results on QFT-2G test.Forty (10.6%) showed among 378 who underwent because active TB disease was clinically suspected. performed these 40 before initiation antituberculous treatment.Forty were judged as showing positive control presented a lower IFN-gamma level. Elderly (68.2 versus 57.7) or immunocompromised receiving immunosuppressive treatments and decrease in lymphocyte count, serum protein albumin more...
Abstract Background This study was designed to evaluate the clinical significance of undifferentiated component in differentiated T1/T2 gastric adenocarcinoma. Methods Two hundred thirty‐one patients who underwent curative gastrectomy were diagnosed pathologically as type cancer according Japanese Classification Gastric Carcinoma (JCGC). The divided into subgroups, pure (pure D group, 181 patients) and differentiated‐predominant mixed (D > U 51 patients). clinicopathological features...
Allergen-specific sublingual immunotherapy is a potential disease-modifying treatment for allergic asthma. Galectin-9 (Gal-9), β-galactoside-binding protein with various biologic effects, acts as an immunomodulator in excessive immunologic reactions by expanding regulatory T cells (Treg) and enhancing transforming growth factor (TGF)-β signaling. We investigated the efficacy of sublingually administered Gal-9 adjuvant to specific allergen Dermatophagoides farinae (Df)-induced mouse model...
Abstract Background Lymphovascular invasion (LVI) is a poor prognostic factor in various malignancies. However, its effect remnant gastric cancer (RGC) remains unclear. We examined the correlation between LVI and disease prognosis patients with T1N0-3 or T2-3N0 RGC whom adjuvant chemotherapy was not indicated treatment strategy established. Methods retrospectively analyzed who underwent curative surgery at Kyoto Prefectural University of Medicine 1997 2019 Chubu Medical Center 2009 2019....
Ten of 140 patients (7.1%) showed negative results on a QFT-2G test. The 10 consisted seven males and three females (mean age: 66.0 years old). Three the had no clinical symptoms underlying diseases. They test repeatedly within 1 month response tuberculin skin (TST). Six remaining were advanced age, all them Although month, one TST. lymphocyte count was normal range in with nutritional conditions. five nine pulmonary tuberculosis cavitary lesions, six lesions one-third unilateral lung field....
Much attention has been directed to the induction of arginase I in lung asthmatic mice. However, there is no agreement on changes serum activity patients among previous studies.The aim this study was evaluate clinical relevance patients.Serum examined cross-sectionally non-smoking (n = 23) and healthy individuals 30) using enzyme-linked immunosorbent assay (ELISA) its correlations with several parameters were investigated.Serum levels significantly increased (mean ± SD 67.4 41.0 ng/mL)...