A5058104472- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Air Quality and Health Impacts
- Toxic Organic Pollutants Impact
- Per- and polyfluoroalkyl substances research
- Carcinogens and Genotoxicity Assessment
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Indoor Air Quality and Microbial Exposure
- Health, Environment, Cognitive Aging
- Maternal Mental Health During Pregnancy and Postpartum
- Chemical Analysis and Environmental Impact
- Noise Effects and Management
- Heavy Metal Exposure and Toxicity
- Pediatric health and respiratory diseases
- Folate and B Vitamins Research
- Allergic Rhinitis and Sensitization
- Obesity, Physical Activity, Diet
- Cardiovascular Health and Disease Prevention
- Mercury impact and mitigation studies
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Breastfeeding Practices and Influences
- Child Nutrition and Feeding Issues
- Workplace Health and Well-being
Hokkaido University
2016-2025
Shimada Municipal Hospital
2025
Sapporo University
2015-2024
Health Sciences University of Hokkaido
2012-2024
Fukushima Medical University
2024
National Institute for Environmental Studies
2024
Nagoya City University
2024
Yokohama City University
1993-2024
University of Yamanashi
2024
The University of Tokyo
2024
There is global concern over significant threats from a wide variety of environmental hazards to which children face. Large-scale and long-term birth cohort studies are needed for better management based on sound science. The primary objective the Japan Environment Children's Study (JECS), nation-wide study that started its recruitment in January 2011, elucidate factors affect children's health development.Approximately 100,000 expecting mothers who live designated areas will be recruited...
Fluorinated organic compounds (FOCs), such as perfluorooctane sulfonate (PFOS), perfluoro-octanoate (PFOA), and sulfonylamide (PFOSA), are widely used in the manufacture of plastic, electronics, textile, construction material apparel, leather, upholstery industries. FOCs have been detected human blood samples. Studies indicated that may be detrimental to rodent development possibly by affecting thyroid hormone levels. In present study, we determined concentrations maternal cord Pregnant...
BackgroundPerfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are man-made, ubiquitous, persistent contaminants in the environment, wildlife, humans. Although recent studies have shown that these chemicals interfere with fetal growth humans, results inconsistent.ObjectivesOur goal was to investigate correlation between relatively low levels of PFOS PFOA maternal serum birth weight size.MethodsWe conducted a hospital-based prospective cohort study July 2002 October 2005 Sapporo,...
The aim of this study was to evaluate the levels semi-volatile compounds (SVOCs) in residential detached houses Sapporo, Japan, and whether exposure these SVOCs associated with development building-related symptoms named 'sick house syndrome' (SHS). definition SHS is fundamentally same as that sick building syndrome (SBS). presence evaluated using a validated self-administered questionnaire. Surveys samplings air dust 41 dwellings were performed from October 2006 January 2007, 134 occupants...
Organophosphate esters are used as additives in flame retardants and plasticizers, they ubiquitous the indoor environment. Phosphorus (PFRs) present residential dust, but few epidemiological studies have assessed their impact on human health. We measured levels of 11 PFRs floor dust multi-surface 182 single-family dwellings Japan. evaluated correlations with asthma allergies inhabitants. Tris(2-butoxyethyl) phosphate was detected all samples (median value: 580 μg/g 111 dust)....
Prenatal di(2-ethylhexyl) phthalate (DEHP) exposure can produce reproductive toxicity in animal models. Only limited data exist from human studies on maternal DEHP and its effects infants. We aimed to examine the associations between utero hormone levels cord blood. Between 2002 2005, 514 pregnant women agreed participate Hokkaido Study Sapporo Cohort. Maternal blood samples were taken 23-35 weeks of gestation concentration primary metabolite DEHP, mono(2-ethylhexyl) (MEHP), was measured....
The Hokkaido Study on Environment and Children's Health is an ongoing study consisting of two birth cohorts different population sizes: the Sapporo cohort cohort. Our primary goals are (1) to examine effects low-level environmental chemical exposures outcomes, including defects growth retardation; (2) follow development allergies, infectious diseases, neurobehavioral developmental disorders perform a longitudinal observation child development; (3) identify high-risk groups based genetic...
Fatty acids (FAs) are essential for fetal growth. Exposure to perfluorinated chemicals (PFCs) may disrupt FA homeostasis, but there no epidemiological data regarding associations of PFCs and concentrations.We estimated between perfluorooctane sulfonate (PFOS)/perfluorooctanoate (PFOA) concentrations maternal levels FAs triglyceride (TG) birth size the offspring.We analyzed 306 mother-child pairs in this cohort 2002 2005 Japan. The prenatal PFOS PFOA were measured serum samples by liquid...
Background:Perfluorinated chemicals (PFCs) disrupt cholesterol homeostasis. All steroid hormones are derived from cholesterol, and such as glucocorticoids androgenic mediate several vital physiologic functions. However, the in utero effects of PFCs exposure on homeostasis these not well understood humans.Objectives:We examined relationship between prenatal to perfluorooctane sulfonate (PFOS)/perfluorooctanoate (PFOA) cord blood levels glucocorticoid hormones.Methods:We conducted a...
Capturing epidemiological signatures is essential to document burdens of disease and design health care services, including prevention measures, clinical interventions, policies. There are large geographical ethnic variations in the epidemiology allergic immunological diseases. Various data available from North America Europe, but diseases Asia not well documented.
Recent studies have suggested that the elevated C-reactive protein (CRP) levels are associated with body fat, especially visceral adipose tissue, but most of them were investigated in Westerners who had higher mass index (BMI) than Asians. To investigate association between CRP concentrations, parameters obesity, insulin resistance syndrome and carotid atherosclerosis healthy Japanese a lower BMI Westerners.We explored relationships fatness obesity [by anthropometry, bioelectrical impedance...