A5063489151- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Eosinophilic Esophagitis
- Dermatology and Skin Diseases
- Neonatal Respiratory Health Research
- Eosinophilic Disorders and Syndromes
- Contact Dermatitis and Allergies
- Immunodeficiency and Autoimmune Disorders
- Urticaria and Related Conditions
- Pregnancy and Medication Impact
- Transgenic Plants and Applications
- Birth, Development, and Health
- Immune Cell Function and Interaction
- Air Quality and Health Impacts
- Vitamin C and Antioxidants Research
- Iron Metabolism and Disorders
- Viral gastroenteritis research and epidemiology
- Reproductive System and Pregnancy
- Probiotics and Fermented Foods
- Child Nutrition and Feeding Issues
- Proteins in Food Systems
- Occupational exposure and asthma
- Virology and Viral Diseases
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Tokushima Prefectural Central Hospital
2025
National Center For Child Health and Development
2018-2024
Tokushima Municipal Hospital
2023
Tokushima University Hospital
2019-2023
Tokushima University
2016-2020
Capturing epidemiological signatures is essential to document burdens of disease and design health care services, including prevention measures, clinical interventions, policies. There are large geographical ethnic variations in the epidemiology allergic immunological diseases. Various data available from North America Europe, but diseases Asia not well documented.
Abstract Background Oral immunotherapy ( OIT ) induces desensitization and/or tolerance in patients with persistent food allergy, but the biomarkers of clinical outcomes remain obscure. Although ‐induced changes serum allergen‐specific IgE and IgG4 levels have been investigated, response other IgG subclasses IgA during remains Methods A pilot study was conducted to investigate egg IgE, subclasses, search for possible prediction desensitization. We measured white‐, ovomucoid‐,...
We evaluated the efficacy and safety of oral immunotherapy (OIT) combined with 24 weeks omalizumab (OMB) at inducing desensitization in children cow's milk allergy (CM) compared an untreated group. The present study was a prospective randomized controlled trial. Sixteen patients (age, 6-14 years) high IgE levels to CM were enrolled study. Patients 1:1 receive OMB-OIT group or primary outcome induction 8 after OMB discontinued treated 32 entry. None 6 developed while all 10 OIT-OMB achieved...
Safer and more effective cow milk (CM)-oral immunotherapy that does not induce allergic reactions has yet been standardised. We sought to explore the efficacy feasibility of a combination heat-killed Lactiplantibacillus plantarum YIT 0132 (LP0132) oral for treating IgE-mediated allergy (CMA). conducted 24-week, double-blind, randomised (1:1), two-arm, parallel-group, placebo-controlled, phase 2 trial LP0132 intervention CMA in children aged 1-18 years (n=60) from January 29, 2018 July 12,...
Allergic rhino-conjunctivitis with pollen allergy has been prevalent worldwide and Pollen-food syndrome (PFAS) refers to individuals who develop oral (OAS) on consuming fruits vegetables. The prevalence of PFAS varies by region that in Japanese adolescents remains be elucidated. In this cross-sectional study, we examined the epidemiological characteristics a general population according allergy, OAS, IgE component sensitization. Participants comprised adolescents, at age 13 years, from...
Allergen-specific immunoglobulin isotype formation associated with class-switching during the lactation period is immunological background for food allergy in infants. We analyzed serial changes production of feeding type-related egg- and milk-specific isotypes from birth to 6 months age or without eczema 84 infants.Allergen-specific G1 (IgG1), IgG2, IgG3, IgG4, IgA, IgE levels hen's egg bovine milk were measured cord blood samples infants at 2, 4, by densely carboxylated protein...
The oral food challenge test (OFC) is the gold standard for evaluating remission of protein-induced enterocolitis syndrome (FPIES). Few acute FPIES remissions confirmed by OFC were reported. This study aimed to examine Japanese children with evaluate its remission. A retrospective cohort was performed on evaluation based one dose (1/50, 1/10, 1/2, and full per day). Acute observed in 65.2% patients (15/23 patients). Vomiting episodes occurred 1/50 doses first day among 75% positive patients....
Background In Japan, swimming school attendance is promoted as a form of therapy or prophylactic measure against asthma in young children. However, the putative beneficial effects have not been sufficiently verified. Objective The aim present study was to clarify whether at age 3 years affects onset and/or improvement wheeze and rhinitis 5 years. Methods This single-center, prospective, general, longitudinal cohort (T-CHILD Study). Between November 2003 December 2005, 1776 pregnant women...
Eosinophilic gastrointestinal disorders are chronic inflammatory diseases in which eosinophils highly infiltrate into tissue, resulting dysfunction. Here, we report a case of pediatric eosinophilic gastroenteritis (EGE). A 7-year-old boy with multiple food allergies (cow milk, hen's egg, fish,shellfish, and chicken) was admitted to our hospital because continuous abdominal pain vomiting. His soy allergy had been diagnosed have oral tolerance based on an challenge at the age 6 years. He EGE...
Few epidemiologic studies have examined the role of maternal iron status in allergic diseases offspring and findings been inconsistent. We used a large birth cohort Japan to explore association markers for (maternal hemoglobin, hematocrit dietary intake during pregnancy) with allergy development early childhood. analyzed information on children age 0–3 years from Environment Children’s Study (JECS). logistic models generalized estimating equation evaluate effect hemoglobin levels allergies...
Abstract Background The study aim was to obtain epidemiological data on vitamin D levels for the pediatric population in Japan. We assessed prevalence of deficiency and insufficiency 2-year-old Japanese children using from a large ongoing birth cohort study. Methods Data analysis obtained Japan Environment Children’s Study (JECS) Sub-Cohort (SCS) JECS. evaluated children’s serum 25(OH) by 5th, 10th, 25th, 50th, 75th, 90th, 95th percentiles, rates or insufficiency. also presented weighted...
Non-esophageal eosinophilic gastrointestinal disorders (non-EoE EGIDs) are chronic inflammatory with massive infiltration of eosinophils into the tract. Food elimination diets potentially effective treatments. But existing dietary therapies have various weak points. We developed a new regimen to compensate for shortcomings elemental diet and 6-food diet. The consists an amino-acid-based formula, potatoes, vegetables, fruits restricted seasonings. named it "Rainbow Elimination Diet (ED)."...
Previous studies have reported that maternal asthma increases the risk of preterm birth. We hypothesized inflammatory reactions caused by allergic diseases might affect uterine environment and, subsequently, perinatal outcomes. The objective this study was to examine associations between features among mothers and pregnancy outcomes in a nationwide birth cohort.We analyzed data from pregnant women obtained Japanese Environment Children's Study (JECS), general cohort study. used binomial...
Allergen-specific immunoglobulins have a crucial role in allergic diseases. Most wheeze episodes develop before school age, and rhinitis later develops during early elementary years. However, the clinical background cytokine/chemokine profiles associated with changes school-age are poorly understood.This study used blood samples from children participating JECS Pilot Study. We examined nineteen kinds of aeroallergen-specific (IgE, IgG1, IgG4, IgA) levels patients at age 6 8. Fluctuations Der...
Background: Although hen's egg (HE) allergy was thought to be usually resolved by late childhood, majority of HE patients with a high level white (HEW)-specific IgE could not acquire tolerance for age 8 years. Objective: The aim is investigate whether the avoidance until 6 years increased risk heated at Methods: This retrospective case-control study. children ( n = 17) and low-dose reactor [a positive reaction ≤ 4 g HEW in oral food challenges (OFCs)] 26) were included based on results OFC...
Background The relationship between allergic individuals and their responsiveness to routine vaccines has rarely been investigated. This study examined whether the seroprevalence of measles antibody differed children with without diseases in general pediatric population. Methods cross-sectional was performed within a prospective birth cohort (a pilot Japan Environment & Children’s Pilot Study [JECS]) aged 8 years. clinical history diseases, measles, concentration immunoglobulin G titers...
Hypertensive disorders of pregnancy (HDP) are one the most common medical conditions that women encounter during pregnancy. Whether or not hypertensive associated with allergic in offspring is unclear. This study used data from a large Japanese birth cohort to investigate whether HDP contributes development at 3 years. We also assessed effect blood pressure different trimesters on children's allergies.We obtained Japan Environment and Children's Study (JECS), which included 104 062 fetal...
Although endotoxin concentration in the environment is negatively associated with atopic dermatitis (AD) onset early childhood, association between and eczema resolution children preexisting unclear. The aim of this study was to evaluate house dust persistence young children. authors used data from participating JECS (Japan Environment Children's Study). In who had AD or AD-like lesions at age 1 year, investigated prevalence 3 years (categorized by quartiles) on children's mattresses ages...