A5073540689- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Psoriasis: Treatment and Pathogenesis
- Drug-Induced Adverse Reactions
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- T-cell and B-cell Immunology
- Cutaneous lymphoproliferative disorders research
- Hair Growth and Disorders
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Cancer Immunotherapy and Biomarkers
- melanin and skin pigmentation
- CAR-T cell therapy research
- Immunodeficiency and Autoimmune Disorders
- Autoimmune Bullous Skin Diseases
- Cutaneous Melanoma Detection and Management
- Food Allergy and Anaphylaxis Research
- Inflammatory Myopathies and Dermatomyositis
- Melanoma and MAPK Pathways
- Nail Diseases and Treatments
- Nonmelanoma Skin Cancer Studies
- IL-33, ST2, and ILC Pathways
- Herpesvirus Infections and Treatments
- Immunotherapy and Immune Responses
Hamamatsu University School of Medicine
2015-2024
Hamamatsu University
2014
Abstract Background The incidence of melanoma among those an Asian ethnicity is lower than in Caucasians; few large‐scale studies that include follow‐up data have been reported. Objectives To investigate the clinical characteristics Japanese patients with and to evaluate prognostic factors. Methods Detailed patient information was collected from database Melanoma Study Group Skin Cancer Society. American Joint Committee on seventh Edition system used for TNM classification. Kaplan‐Meier...
Alopecia areata (AA) is regarded as a tissue-specific and cell-mediated autoimmune disorder. Regarding the cytokine balance, AA has been considered type 1 inflammatory disease. On other hand, often complicates atopic dermatitis (AD) AD 2 However, immunological aspects of in relation to are still poorly understood. Therefore, we aim clarify properties AD-associated AA. In this study, performed comparative analysis expression intracytoplasmic cytokines (IFN-γ, IL-4, IL-13), chemokine receptors...
In drug-induced hypersensitivity syndrome (DIHS), latent human herpesvirus (HHV)-6 is frequently reactivated in association with flaring of symptoms such as fever and hepatitis. We recently demonstrated an emergence monomyeloid precursors expressing HHV-6 antigen the circulation during this clinical course.To clarify mechanism reactivation, we immunologically investigated peripheral blood mononuclear cells (PBMCs), skin-infiltrating cells, lymphocytes expanded from skin lesions patients...
Alopecia areata (AA) is a tissue-specific autoimmune disease, and interferon (IFN)-γ has been regarded as the key cytokine in pathogenesis of AA. The clinical observation that AA can occur after viral infection or IFN-α administration implies IFN-α-producing plasmacytoid dendritic cells (pDCs) may be involved pathogenesis.We generated C3H/HeJ mice by intradermal injection T derived from lymph nodes AA-bearing syngeneic stimulated IL-2, IL-7, IL-15. Distribution IFN-γ producing pDCs were...
Abstract Background Mogamulizumab (Mog) is a defucosylated, therapeutic monoclonal antibody, targeting CCR4 and was first approved in Japan for the treatment of adult T‐cell leukaemia/lymphoma (ATLL), followed by cutaneous lymphoma peripheral lymphoma. Objective To retrospectively investigate development photosensitivity patients with mycosis fungoides other neoplasms after Mog. Methods We treated seven Upon combination narrow‐band UVB, we noticed that four developed dermatitis following Mog...
AbstractBenzo[a]pyrene [B(a)P], a potent procarcinogen found in combustion products such as diesel exhaust and cigarette smoke, has been recently shown to activate the c-Jun NH2-terminal kinase 1 (JNK1) induce caspase-3-mediated apoptosis Hepa1c1c7 cells. However, molecules of signaling pathway that control mitogen-activated protein cascades induced by B(a)P interaction between those have not well defined. We report here promoted Cdc42/Rac1, p21-activated (PAK1), JNK1 activities 293T HeLa...
Dermatomyositis (DM) and polymyositis (PM) are collectively termed autoimmune myopathy. To investigate the difference between muscle- skin-infiltrating T cells to address their role for myopathy, we characterized that were directly expanded from tissues. Enrolled into this study 25 patients with DM three PM. Muscle skin biopsied specimens immersed in cRPMI medium supplemented interleukin (IL)-2 anti-CD3/CD28 antibody-conjugated microbeads. The subjected flow cytometry examine phenotypes. We...
Palmar hyperlinearity is a typical clinical feature of Filaggrin gene (FLG) null mutations. There are reports FLG mutations and allergic sensitization; however, on the relationship between palmar to sensitization limited. This study aimed examine association in atopic dermatitis (AD) children.This cross-sectional, case-control included children ˂ 6 years old with moderate-severe AD whose parents consented for mutation analysis photographic documentation. Each child underwent genotyping...