A5046943650- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Nutritional Studies and Diet
- Glutathione Transferases and Polymorphisms
- Cancer Risks and Factors
- DNA Repair Mechanisms
- Gastric Cancer Management and Outcomes
- Air Quality and Health Impacts
- Folate and B Vitamins Research
- Fatty Acid Research and Health
- Helicobacter pylori-related gastroenterology studies
- Nutrition, Genetics, and Disease
- Epigenetics and DNA Methylation
- Occupational and environmental lung diseases
- Smoking Behavior and Cessation
- Alcohol Consumption and Health Effects
- Phytoestrogen effects and research
- Endometriosis Research and Treatment
- Genetic factors in colorectal cancer
- Tea Polyphenols and Effects
- Microplastics and Plastic Pollution
- Per- and polyfluoroalkyl substances research
- Genomics, phytochemicals, and oxidative stress
- Occupational exposure and asthma
Showa University
2006-2024
Hokkaido University
2011-2021
Sapporo University
2019
Yokufukai Hospital
2010-2016
Saitama Medical University
2014
Social Insurance Saitama Chuo Hospital
2014
National Cancer Centre Japan
1993-2013
Health Sciences University of Hokkaido
2011
University of Occupational and Environmental Health Japan
2006
Prevention Group
2004-2006
Observations of adverse developmental and reproductive effects in laboratory animals wildlife have fueled increasing public concern regarding the potential for various chemicals to impair human fertility.Our objective this study was assess effect occupational exposure high levels phthalate esters on balance gonadotropin gonadal hormones including luteinizing hormone, follicle-stimulating free testosterone (fT), estradiol.We examined urine blood samples 74 male workers at a factory producing...
The Hokkaido Study on Environment and Children's Health is an ongoing study consisting of two birth cohorts different population sizes: the Sapporo cohort cohort. Our primary goals are (1) to examine effects low-level environmental chemical exposures outcomes, including defects growth retardation; (2) follow development allergies, infectious diseases, neurobehavioral developmental disorders perform a longitudinal observation child development; (3) identify high-risk groups based genetic...
Aims: To evaluate effects of exposure to bisphenol A diglycidyl ether (BADGE) on urinary excretion A, and plasma gonadotrophic hormones testosterone in male epoxy resin sprayers. Methods: Cross sectional study 42 workers whose job was spray hardening agents including BADGE mixed organic solvents, matched control without use the same machine plants. Results: Concentrations were higher sprayers (median 1.06 μmol/mol creatinine) compared with controls 0.52 creatinine). Urinary metabolite...
Abstract Background: Although accumulating evidence suggests that Helicobacter pylori plays a role in gastric carcinogenesis, the magnitude of risk remains uncertain. Aim: We aimed to estimate cancer associated with H. infection by large case-control study nested within prospective cohort. Possible effect modification CagA status, and serum pepsinogen as marker atrophic gastritis, was also considered see its on developing cancer. Subjects Methods: (n = 123,576) were followed up from 1990...
An anthelminthic, pyrvinium pamoate (PP), 6‐(dimethylamino)‐2‐[2‐(2,5‐dimethyl‐1‐phenyl‐1 H ‐pyrrol‐3‐yl)ethenyl]‐1‐methyl‐quino‐linium salt, has been found to be extremely toxic PANC‐1 cells in glucose‐free medium, but not the same cultured ordinary Dulbecco's modified Eagle's medium (DMEM). It showed preferential toxicity for various cancer cell lines during glucose starvation. When 0.1 μg/ml PP was added spheroid growth of human colon line WiDr strongly inhibited a diameter 750 μm, and...
AimsAlthough dietary saturated fatty acids (SFA) are considered atherogenic, associations between SFAs intake and stroke coronary heart disease still debated. We sought to test the hypothesis that SFA is associated inversely with risk of its subtypes positively among Japanese, whose average lower than Westerners.
Abstract We assessed the possible association of gastrointestinal cancers with cruciferous vegetables and mushrooms in a multicenter, hospital-based case-control study an agricultural area Japan. One hundred forty-nine cases 287 controls for stomach cancer 115 230 colorectal were matched by age, sex, residential area. In cancer, protective effect (consumption total vegetable) was obscure, but it became clearer when we examined specific kinds vegetables. Marginal associations observed group...
The development of new strategies designed to detect DNA damage caused by oxidative stress and other means may advance our understanding the roles such types in etiology cancers, aging processes, as biomarkers exposure. A adduct detection method that uses liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC/ESI–MS/MS) multiple adducts human lung tissue is reported herein. This adductome analysis strategy neutral loss 2´-deoxyribose from positively ionized...
Abstract Abstract: We conducted a case-control study to investigate the association of nutrient intake involved in one-carbon pathway folate for DNA methylation and synthesis related enzyme genetic polymorphisms with colorectal cancer. Cases were 107 patients newly diagnosed Controls 224 subjects matched cases by sex, age, residential area. Nutrient was assessed self-administered, semiquantitative food-frequency questionnaire. Four polymorphisms—MTHFR C677T A1298C, MTRR A66G, ALDH2...
From 1985 to 2013, the mean birth weight of infants in Japan decreased from 3120 g 3000 g, and low-birth-weight rate among live births increased 6.3% 9.6%. No prospective study has elucidated risk factors for poor fetal growth preterm recent Japanese parents, such as parental age, maternal body figure, assisted reproductive technology (ART), socioeconomic status. Participants were mother-infant pairs (n = 18,059) enrolled a cohort Hokkaido, 2002 2013. Parental characteristics obtained via...
Background: Stomach cancer is an important health problem in Brazil, with estimated 20 000 new cases per year and it was the most frequent site men third women São Paulo 1993. Nevertheless, there are no reports of analytical epidemiological study on stomach Brazil.
Progression of endometriosis is considered estrogen-dependent. Dietary soy isoflavones may affect the risk endometriosis, and polymorphisms in estrogen receptor genes modify this association. We examined associations among isoflavone intake, 2 (ESR2) gene endometriosis.We recruited women age 20-45 years old who had consulted a university hospital for infertility Tokyo, Japan 1999 or 2000. A total 138 eligible were diagnosed laparoscopically classified into 3 subgroups: control (no...
We conducted a cross-sectional molecular epidemiological study of coke oven workers exposed to the established carcinogen polycyclic aromatic hydrocarbons (PAHs) evaluate relationships between both traditional 'exposure markers' and series biomarkers, including urinary 1-hydroxypyrene as marker internal dose, leukocyte DNA adducts markers biologically effective serum p53 protein response genetic polymorphisms cytochrome P4501A1 glutathione S-transferase MI susceptibility markers. Twenty-five...
Abstract To examine the hypothesis that tobacco smoke is associated with risk of female breast cancer, we estimated relative risks active and passive in middle‐aged Japanese women a population‐based prospective study. The cohort consisted residents 4 public health center areas, aged 40 to 59 years. A self‐administered questionnaire survey was conducted 1990. This analysis included 21,805 subjects, 180 whom had developed cancer by December 31, 1999. When reference defined as never‐active...