A5033625421- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Asthma and respiratory diseases
- Ear and Head Tumors
- Oral and Maxillofacial Pathology
- Mast cells and histamine
- Multiple and Secondary Primary Cancers
- Cervical Cancer and HPV Research
- Bone Tumor Diagnosis and Treatments
- Tumors and Oncological Cases
- Crystallization and Solubility Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Head and Neck Surgical Oncology
- X-ray Diffraction in Crystallography
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Viral-associated cancers and disorders
- Ginkgo biloba and Cashew Applications
- Tea Polyphenols and Effects
- Neurofibromatosis and Schwannoma Cases
- Allergic Rhinitis and Sensitization
- T-cell and Retrovirus Studies
- Food Allergy and Anaphylaxis Research
- Autoimmune Bullous Skin Diseases
Japan Atomic Energy Agency
2024
Futaba (Japan)
2024
University of the Ryukyus
2012-2022
University of the Ryukyus University Hospital
2007-2021
Hyogo Prefectural Institute of Environmental Sciences
1999
We investigated the value of deep learning (DL) in differentiating between benign and metastatic cervical lymph nodes (LNs) using pretreatment contrast-enhanced computed tomography (CT). This retrospective study analyzed 86 234 (non-metastatic) LNs at levels I–V 39 patients with oral squamous cell carcinoma (OSCC) who underwent preoperative CT neck dissection. were randomly divided into training (70%), validation (10%), test (20%) sets. For sets, I–II evaluated. Convolutional neural network...
Low-grade myofibroblastic sarcoma (LGMS) is a neoplasm of the soft tissue characterized by differentiation. This type tumor has been observed in various sites whole body, but frequently occurs head and neck region. It typically presents as slow-growing painless mass, which often mistaken for benign lesion due to its indolent growth; however, LGMS malignant neoplasm. In present study, 43-year-old female presented with 14-mm buccal subcutaneous tissues buccinator muscle. The patient had...
MicroRNAs (miRs) are expected to serve as prognostic tools for cancer. However, many miRs have been reported markers of recurrence or metastasis in oral squamous cell carcinoma patients. We aimed determine the early-stage tongue (TSCC). Based on previous studies, we hypothesized that miR-10a, 10b, 196a-5p, 196a-3p, and 196b were retrospectively performed miR expression analyses using formalin-fixed paraffin-embedded sections surgical specimens. Total RNA was isolated from cancer tissues...
Low-risk human papillomavirus (HPV), such as types 6 and 11, is considered non-oncogenic, but these have been detected in oral cancer tissue samples, suggesting their possible involvement carcinogenesis. Because double infection of high-risk HPV Epstein-Barr virus (EBV) known to be involved carcinogenesis, we hypothesized that low-risk EBV co-infection can transform the cells. To verify our hypothesis, evaluated transformation activity cell lines expressing both E6/E7 LMP-1.We transduced...
Reports of synchronous multiple primary cancers in patients with oral cancer have recently been increasing because progress radiographic diagnostic techniques. Multiple cavity mainly occur the head and neck region, lung, esophagus. 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography is usually used to identify cancers.We herein describe a 69-year-old woman diagnosed quadruple cancers, namely squamous cell carcinoma mobile tongue, invasive ductal right breast, intraductal left...
Inflammation is associated with disease progression and, by largely unknown mechanisms, has been said to drive oncogenesis. At inflamed sites, neutrophils deploy a potent antimicrobial arsenal that includes proteinases, peptides, and ROS. Reactive oxygen species (ROSs) induce chemokines. In the present study, concentrations of IL-8 in culture supernatants HeLa cells treated ROS were determined enzyme-linked immunosorbent assay. We used -phenanthroline deplete order investigate mechanisms...
Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare self‑limiting disorder typically affecting the cervical lymph nodes (LNs), which often misdiagnosed other LN‑associated diseases. KFD frequently presents with necrotic lesions and recurrences, are features of metastatic LNs. Clinicians may thus suspect LN metastasis when they encounter ipsilateral lymphadenopathy in patient head neck cancer. The present study reports case 48‑year‑old man tongue...
Dedifferentiated liposarcoma (DDLS) has a relatively poor prognosis, however this neoplasm rarely occurs in the head and neck. To date, no definite protocol been established for diagnosis treatment of neck DDLS. The present study reports case 69‑year‑old male patient with DDLS oral floor. best our knowledge, is first documented floor In addition, reported development second primary malignancy following A literature review 50 cases revealed that preoperative biopsy not reliable these tumors...
Mixed tumour of the skin or chondroid syringoma (CS) is a rare and mostly benign neoplasm sweat glands. Although CS frequently located on varied parts head neck region, lower lip rarely reported site. The present report describes case in 58-year-old male as an expository to further emphasise need for proper diagnosis, appropriate treatment prognostic evaluation. patient presented with round, non-tender, slightly hard mobile mass beneath mucocutaneous junction his left lateral side lip....
Background/Aim: Oral squamous cell carcinoma (OSCC) is a common malignancy with poor prognosis. Therefore, novel therapeutic options are needed to improve prognosis of OSCC. Recently, microRNAs (miRs) have received increasing attention as potential tool for carcinomas. However, no definitive miR-based drugs patients OSCC been reported date. The aim this study was identify new miRs potentially involved in cellular processes associated malignancy, which could lead strategies. Materials and...
頸部リンパ節は舌癌の予後に影響する。1986年から2004年までにおけるstage I,II舌癌113例の検討を行った。26例に予防的頸部郭清術が行われ,これら8例に一次転移が認められた。一方,87例には予防的頸部郭清術は行わず,26例に後発転移が認められた。今回の検討において,悪性度とリンパ節転移に明らかな関連性は示されなかった。一方,浸潤様式はリンパ節転移に有意な因子であった。5年累積生存率に関しては一次転移群が87.5%,後発転移群が57.5%であった。頸部死,遠隔転移死はそれぞれ6例に認められた。また,被膜外浸潤は,後発転移群のみに認められた。これらの結果より,リンパ節転移において浸潤様式と被膜外浸潤が重要な予後因子であることが示唆された。Stage I,II舌癌における予防的郭清術の適用について,さらなる研究を検討するべきであろう。
Mucoepidermoid carcinomas (MECs) are rare head and neck malignant tumours that were originally considered to be benign. It has been estimated ~20% of MECs in the major salivary glands, such as parotid gland, 50% several minor glands found oral cavity, malignant. The diagnosis is mainly based on ancillary immunohistochemistry testing. However, owing difficulty harvesting adequate material for histological examination, histopathological intraoral may particularly challenging. We herein report...
Macroglossia is the most prominent oral manifestation occurring in 20% of patients with amyloidosis, but resection tongue rarely needed. We report a case amyloidosis that presented remarkable enlargement due to which was successfully resected excellent cosmetic results. A 74-year-old woman referred 6-month history progressive tongue, difficulty closing mouth, and dysphagia associated solid food. Amyloidosis macroglossia suspected, biopsy were performed. The 100 × 80 65 mm 76.7 g....
Second primary cancer (SPC) is an important prognostic factor for patients with head and neck (HNC); therefore, the association between prognosis development of SPC has been well-reported. The use 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) valuable to examine stage, evaluate treatment responses investigate suspected relapses or metastases. In present study, case a male patient who was diagnosed three types, including well moderately differentiated squamous cell...
Currently, Kaposi's sarcoma (KS) is treated following the recommendations of international guidelines. These guidelines recommend esophagogastroduodenoscopy/colonoscopy for detecting multicentric KS visceral lesions. Second primary malignancies (SPMs) are also a common complication; however, information on their detection and treatment unfortunately not yet indicated in these This paper reports an 86-year-old man who suffered from quadruple malignancies: skin classic with colon...