A5061041268- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Coronary Interventions and Diagnostics
- Eicosanoids and Hypertension Pharmacology
- Cardiac Imaging and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Congenital Heart Disease Studies
- Metabolism and Genetic Disorders
- Cardiac pacing and defibrillation studies
- Organ Transplantation Techniques and Outcomes
- Pancreatic and Hepatic Oncology Research
- Head and Neck Surgical Oncology
- Pancreatic function and diabetes
- Ginkgo biloba and Cashew Applications
- Tea Polyphenols and Effects
- Neonatal Health and Biochemistry
- Nutritional Studies and Diet
- Acute Myocardial Infarction Research
- Liver physiology and pathology
- Family and Disability Support Research
- Ultrasound in Clinical Applications
- Pericarditis and Cardiac Tamponade
- Magnesium in Health and Disease
- Neurofibromatosis and Schwannoma Cases
Kyushu University
2019-2025
Shimane Prefectural Central Hospital
2017-2025
Okinawa Prefectural Chubu Hospital
2022
Juntendo University
2017
Katsushika Medical Center
2017
Adeka (Japan)
2012
Yamaguchi University
2005
Koga Hospital
2005
Kagawa Prefectural Central Hospital
1996
Background:We investigated the incidence of acute coronary syndrome (ACS) in a non-epidemic area coronavirus disease-2019 (COVID-19) Japan.
Aim . Immune checkpoint inhibitors (ICIs) have improved the survival rate of patients carrying various malignant neoplasms. Despite their efficacy, ICIs occasionally induce liver injury as an immune-related adverse event (irAE). This study aimed to reveal clinical features hepatic irAE in Japanese patients. Methods Among 387 treated with ICIs, those who developed drug-induced were investigated. We also describe histological findings and courses four underwent biopsy. Results 56 all-grade...
Abstract Acute liver failure (ALF) is a serious disease that progresses from acute injury (ALI) and often leads to multiorgan ultimately death. Currently, effective treatment strategies for ALF, aside transplantation, remain elusive, partly because ALI highly heterogeneous. Furthermore, clinicians lack quantitative indicator they can use predict which patients hospitalized with will progress ALF the need transplantation. In our study, we retrospectively analyzed data 319 admitted hospital...
The differentiation of the Academic Research Consortium high bleeding risk (HBR) (ARC-HBR) criteria and those modified for Japanese patients (J-HBR) predicting events following discharge in with acute coronary syndrome (ACS) has yet to be clarified. In this study, we compared ARC-HBR J-HBR post-discharge associated ACS. We retrospectively analyzed data from 889 ACS discharged alive at two tertiary hospitals Japan between August 2009 July 2018. identified HBR using both sets criteria....
The Fontan procedure has improved the prognosis of patients with a functional single ventricle; however, late complications-including Fontan-associated liver disease (FALD)-have surfaced as clinical concerns. FALD signs portal hypertension been defined advanced (aFALD) due to its poor prognosis. Recently, noninvasive tests (NITs) have found predict fibrosis in FALD. Liver stiffness measurement excluding strain elastography (SE) was affected by hepatic congestion; our knowledge, not many...
Objective. Metabolic alteration is widely considered as one of the hallmarks cancer. Hepatocellular carcinoma (HCC) presents a unique pathological feature in which lipid accumulation common well-differentiated HCC and rare poorly differentiated HCC; however, underlying mechanism remains unclear. Methods. Tissue samples were obtained from 103 patients who had undergone hepatic resection 12 living donors liver transplantation. We evaluated metabolic gene expressions cancer tissues well...
Abstract Background Ornithine transcarbamylase deficiency (OTCD) is most common among urea cycle disorders (UCDs), defined by defects in enzymes associated with ureagenesis. Corticosteroid administration to UCD patients, including OTCD suggested be avoided, as it may induce life-threatening hyperammonemia. The mechanism has been considered nitrogen overload due the catabolic effect of corticosteroids; however, pathophysiological process unclear. Methods To elucidate hyperammonemia induced...
Bacillus cereus is a gram-positive rod bacterium that responsible for food poisoning. It naturally widely distributed, and thus often contaminates cultures. Although it rarely considered responsible, can cause serious infections under certain conditions. However, lethal infections, especially in immunocompetent patients, are rare. A healthy 60-year-old man developed community-acquired B. pneumonia alveolar hemorrhage unveiled by abrupt chest pain hemoptysis with no other advance symptoms....
Microcirculatory disturbance is thought to be involved in the pathogenesis of acute liver injury (ALI). The current study examined pathophysiologic role hepatic microcirculatory patients with ALI and mouse models ALI. Using serum aminotransferase (ALT)/lactate dehydrogenase (LDH) ratio as a hypoxic marker, 279 were classified into low ALT/LDH (ALT/LDH ≤1.5) high group >1.5). In group, ALT, LDH, fibrinogen degradation products prothrombin time‑international normalized increased relative...
α-Amylase (EC 3.2.1.1) hydrolyzes an internal α-1,4-glucosidic linkage of starch and related glucans. Alkalophilic liquefying enzymes from Bacillus species are utilized as additives in dishwashing laundry detergents. In this study, we found that sp. AAH-31, isolated soil, produced alkalophilic α-amylase with high thermostability. Extracellular AAH-31 (AmyL) was purified seven steps. The enzyme showed a single band 91 kDa on SDS-PAGE. Its specific activity hydrolysis 0.5% soluble 16.7 U/mg....
Abstract The study aimed to evaluate the association between green tea and coffee consumption risk of kidney cancer using data from a large prospective cohort in Japan (the Public Health Center-based Prospective Study: JPHC Study). A total 102,463 participants aged 40–69 were followed during 1,916,421 person-years (mean follow-up period, 19 years). 286 cases (199 men, 87 women) identified. Cox proportional hazards regression models used estimate hazard ratios (HRs) 95% confidence intervals...
Acute liver failure (ALF) is a life-threatening disorder that progresses from self-limiting acute injury (ALI). Microcirculatory disturbance characterized by sinusoidal hypercoagulation and subsequent massive hypoxic hepatocyte damage have been proposed to be the mechanism which ALI deteriorates ALF; however, precise molecular pathway of remains unknown. Here, we analyzed patients mice models uncover pathogenesis with microcirculatory disturbance.
Abstract The distribution of human herpesvirus 6 (HHV‐6) and varicella‐zoster virus (VZV) was examined in autopsy samples from a fatal case with both infections. A 9‐month‐old boy developed convulsive seizures followed by macular skin rashes, rapidly progressed to brain death, died 15 days after the onset, when signs varicella were noted. An isolation HHV‐6 blood evaluation antibody activities various viral agents including performed before his death. Postmortem examinations included: (i)...
The increasing number of patients with fatty liver disease is a major health problem. Fatty metabolic dysfunction has been recognized as nonalcoholic (NAFLD). Although there no standard therapy for NAFLD, previous reports support the effect sodium-glucose cotransporter 2 (SGLT2) inhibitors on NAFLD. Recently, was proposed to be defined novel concept, “metabolic associated (MAFLD)”, and it that new criteria MAFLD diagnosis established. To clarify SGLT2 MAFLD, we analyzed efficacy...
In developed countries, the incidence of non-ST-segment elevation myocardial infarction (NSTEMI) has outpaced that ST-segment (STEMI). However, whether this trend is observed in Japan, which aging society rapidly progressing, remains to be elucidated.
Recombinant human soluble thrombomodulin alpha (rhTM) has been developed as an anticoagulant with anti-inflammatory activity. Notably, acetaminophen (APAP) -induced liver disease (AILI) is caused by direct metabolite-induced hepatotoxicity well hepatic hyper-coagulation. To evaluate the utility of for treatment AILI, rhTM was administered in a mouse AILI model and damage analyzed. induced 8-week-old mice intraperitoneal injection APAP. (20 mg/kg) or placebo injected at same time APAP...
Acute kidney injury (AKI) is a common complication of acute liver failure (ALF); but its pathogenesis unknown. ALF was divided into 2 subgroups; with hepatic coma, which corresponds to in the US and Europe, without coma. AKI has been shown worsen prognosis patients coma; however, prognostic significance coma remains A single-center retrospective study 174 performed. defined according KDIGO criteria. developed 29 (66.0%) 44 27 (38.5%) 130 Systemic inflammatory response syndrome (SIRS) found...