A5083314513- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Reproductive tract infections research
- HIV, Drug Use, Sexual Risk
- Antimicrobial Resistance in Staphylococcus
- HIV/AIDS drug development and treatment
- Bacterial biofilms and quorum sensing
- Pneumocystis jirovecii pneumonia detection and treatment
- Syphilis Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Colorectal and Anal Carcinomas
- Blood groups and transfusion
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Microbial infections and disease research
- Bacterial Infections and Vaccines
- COVID-19 and healthcare impacts
- Nutritional Studies and Diet
- Herpesvirus Infections and Treatments
- Ginkgo biloba and Cashew Applications
- Adolescent Sexual and Reproductive Health
- Influenza Virus Research Studies
- Antibiotic Resistance in Bacteria
- Reproductive Health and Contraception
National Center for Global Health and Medicine
2015-2025
Kumamoto University
2023
University of Birmingham
2021-2022
Center for Global Health
2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Association for Cancer Surgery
2021
The University of Tokyo
2013-2017
Osaka Prefectural Institute of Public Health
2017
ABSTRACT Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) strains, which often produce Panton-Valentine leucocidin (PVL), are increasingly noted worldwide. In this study, we examined 42 MRSA strains (25 PVL-positive [PVL + ] and 17 PVL-negative − strains) isolated in Taiwan for their molecular characteristics. The PVL included CA-MRSA with multilocus sequence type (ST) 59 (major Taiwan), its variants, worldwide ST30 strains. the pandemic Hungarian ST239 strain,...
ABSTRACT Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) was collected from children with bullous impetigo in 2003 and 2004. One strain Panton-Valentine leucocidin (PVL) positive. In 2004, a multiple-drug-resistant PVL + CA-MRSA isolated an athlete cutaneous abscess. These strains were analyzed by multilocus sequence typing, spa agr coagulase staphylococcal cassette chromosome mec (SCC ) PCR assay for 30 virulence genes, drug susceptibility testing, pulsed-field gel...
Background. Tenofovir is a widely used antiretroviral drug although it can cause kidney tubular dysfunction (KTD). The aim of this study was to determine the association between polymorphisms in genes encoding transporters and KTD Japanese patients treated with tenofovir. Methods. tenofovir-induced 14 single nucleotide (SNPs) ABCC2, ABCC4, ABCC10, SCL22A6, ABCB1 investigated 190 patients. diagnosed by presence at least 3 abnormalities following parameters: fractional resorption phosphate,...
AimsAlthough dietary saturated fatty acids (SFA) are considered atherogenic, associations between SFAs intake and stroke coronary heart disease still debated. We sought to test the hypothesis that SFA is associated inversely with risk of its subtypes positively among Japanese, whose average lower than Westerners.
SUMMARY Invasive pneumococcal disease (IPD) is of concern in Japan, where the heptavalent conjugate vaccine (PCV7) unavailable. We determined serotypes, genotypes indicating β-lactam resistance, and antibiotic susceptibilities 496 isolates from normally sterile sites patients (193 children, 303 adults) 186 institutions between August 2006 July 2007. Disease presentations included sepsis (46·2%), pneumonia (31·5%), meningitis (17·5%). Mortality was 1·4% children 22·1% adults, many whom had...
The ST5 lineage of methicillin-resistant Staphylococcus aureus (MRSA) is one the most globally disseminated hospital-associated MRSA (HA-MRSA) lineages. We isolated a new local variant (designated ST764) over at least 5 years that causes invasive infections, including necrotizing fasciitis, and carried by medical students, as well household members. Analysis genome sequence isolate compared to reference strain revealed ST764 had acquired virulence traits similar those community-associated...
Background and Aims: Men who have sex with men (MSM) are vulnerable to contracting HBV as a sexually transmitted infection. We evaluated the incidence of infection (HBI) prophylactic effect tenofovir-based pre-exposure prophylaxis (PrEP) on HBI in an MSM cohort. Methods Results: were older than 16 years enrolled from January 2018 followed up until June 2021 tested for HIV, bacterial infections, HBsAg/ HBsAb HBcAb every 3 months based inclusion criteria, including HBsAg, HBcAb, HBsAb, HIV...
We prospectively assessed asymptomatic monkeypox virus infections among men who have sex with in Tokyo, Japan, during the initial phase of mpox epidemic. Our findings suggest that were likely underestimated and comparable magnitude to symptomatic infections, highlighting need improve testing accessibility high-risk populations.
Amoxicillin plus probenecid is an alternative to intramuscular benzathine penicillin G for treating syphilis in the United Kingdom. Low-dose amoxicillin treatment option used Japan.We conducted open-label, randomized, controlled, non-inferiority trial between 31 August 2018, and 3 February 2022, compare 1500 mg low-dose monotherapy with combination of 3000 (non-inferiority margin 10%). Patients human immunodeficiency virus (HIV) infection were eligible. The primary outcome was cumulative...
Mycoplasma genitalium has a tendency to develop macrolide and quinolone resistance.We investigated the microbiological cure rate of 7 day course sitafloxacin for treatment rectal urogenital infections in MSM.This open-label, prospective cohort study was conducted at National Center Global Health Medicine, Tokyo, Japan from January 2019 August 2022. Patients with M. or were included. The patients treated 200 mg daily days. isolates tested parC, gyrA 23S rRNA resistance-associated mutations.In...
Abstract The major methicillin‐resistant Staphylococcus aureus (MRSA) distributed among hospitals in Japan is New York/Japan clone [multilocus sequence type 5 (ST5), agr 2 and methicillin resistance locus (SCC mec ) II] which possesses both the toxic shock syndrome toxin 1 gene ( tst staphylococcal enterotoxin C sec ). In this study, we collected 245 MRSA strains from four during 2001 to 2005 Niigata, Japan, analyzed genes SCC them. A total of 13 were further examined for their genotypes,...
Men who have sex with men (MSM) are at high risk of HIV infection. However, there only few data on prevalence in MSM Japan. The objective this study was to explore the Shinjuku 2-chome, a well known gay quarter Tokyo.MSM directly collected dried blood spot (DBS) self-collection test kit from drop-in center 2-chome between August 2015 and December 2016. participants their own by finger-prick anonymously posted laboratory. accessed website checked results tests using unique ID password. DBS...
To assess the prevalence and antibiotic resistance profile of Mycoplasma genitalium detected from urogenital/rectal swab samples obtained MSM in Tokyo, Japan.We performed PCR-based screening for M. infection 982 asymptomatic between 1 January 2019 5 November 2020. Mutations resistance-associated genes gyrA parC 23S rRNA were analysed.The was 6.1%: rectal urogenital 4.7% 1.4%, respectively. Among cases, 48 successfully analysed rRNA, 41 mutations 37 mutations. Macrolide- quinolone-resistance...
Community‐acquired methicillin‐resistant Staphylococcus aureus (CA‐MRSA) with Panton‐Valentine leukocidin (PVL) genes is increasing worldwide. Nosocomial outbreak‐derived (hospital‐acquired) MRSA (HA‐MRSA) in Japan the 1980s was also largely PVL + . HA‐MRSA and CA‐MRSA shared same multi‐locus sequence type (ST30) methicillin resistance cassette (SCC mec IV), but were divergent oxacillin resistance, spa typing, PFGE analysis or clfA gene analysis. HA‐MRSA, which probably originated S. ST30,...
Among bullous impetigo isolates, exfoliative toxin (ET) gene carriage was found in 61.5% of methicillin-resistant Staphylococcus aureus (MRSA) isolates versus 90.6% methicillin-susceptible S. (MSSA) isolates. MRSA-only cases were ETB or ETA positive, while MRSA/MSSA coinfection ET negative for MRSA but positive MSSA. Collagen adhesin may facilitate some infections.
Abstract Background Mycoplasma genitalium, which causes sexually transmitted diseases, is increasingly resistant to key antibiotics such as macrolides and quinolones, posing a challenge for treatment. Objectives To assess the effectiveness of prolonged sitafloxacin doxycycline combination therapy new alternative treatment strategy highly drug-resistant M. genitalium strains Methods A prospective cohort study was conducted at National Center Global Health Medicine, Tokyo, Japan, from 1...
Objective To examine the prevalence of illicit drug use among men who have sex with (MSM) HIV-1 infection in Japan, where life-time general population is only 2.9%. Design A single-center cross-sectional study at a large HIV clinic Tokyo, which treats approximately 15% infected patients Japan. Methods The and assciation characteristics social demographics were examined. Patients visited for first time from 2005 to 2010 enrolled. Relevant variables collected using structured interview medical...