A5087872533- Birth, Development, and Health
- Per- and polyfluoroalkyl substances research
- Air Quality and Health Impacts
- Toxic Organic Pollutants Impact
- Gestational Diabetes Research and Management
- Effects and risks of endocrine disrupting chemicals
- Health, Environment, Cognitive Aging
- Pregnancy and preeclampsia studies
- Breastfeeding Practices and Influences
- Cleft Lip and Palate Research
- Smoking Behavior and Cessation
- Folate and B Vitamins Research
- Heavy Metal Exposure and Toxicity
- Carcinogens and Genotoxicity Assessment
- Chemical Analysis and Environmental Impact
- Pediatric health and respiratory diseases
- Infant Health and Development
- Neuroscience of respiration and sleep
- Craniofacial Disorders and Treatments
- Epigenetics and DNA Methylation
- Obesity, Physical Activity, Diet
- Neonatal Respiratory Health Research
- Mercury impact and mitigation studies
- Prenatal Substance Exposure Effects
- Climate Change and Health Impacts
Sapporo University
2016-2024
Hokkaido University
2015-2024
National Institute of Occupational Safety and Health
2023-2024
Center for Environmental Health
2018-2024
Health Sciences University of Hokkaido
2017-2024
Shimane University
2023
Adult Congenital Heart Association
2023
Kanazawa Medical University
2023
Hokkaido Institute of Public Health
2011-2016
The Hokkaido Study on Environment and Children's Health is an ongoing study consisting of two birth cohorts different population sizes: the Sapporo cohort cohort. Our primary goals are (1) to examine effects low-level environmental chemical exposures outcomes, including defects growth retardation; (2) follow development allergies, infectious diseases, neurobehavioral developmental disorders perform a longitudinal observation child development; (3) identify high-risk groups based genetic...
Abstract Background The Hokkaido Study on Environment and Children’s Health is an ongoing study consisting of two birth cohorts different population sizes: the Sapporo cohort cohort. Our primary objectives are to (1) examine effects that low-level environmental chemical exposures have outcomes, including defects growth retardation; (2) follow development allergies, infectious diseases, neurobehavioral developmental disorders, as well perform a longitudinal observation child development; (3)...
The extremes of maternal pre-pregnancy body mass index (BMI) are known to be risk factors associated with obstetric and adverse perinatal outcomes. Among Japanese women aged 20 years or older, the prevalence underweight (BMI < 18.5 kg/m2) was 11.5% in 2019. Maternal thinness is a health problem caused by desire become slim. This study aimed investigate association between severity low BMI outcomes, including preterm birth (PTB), weight (LBW), small-for-gestational age (SGA).We conducted...
It is necessary to determine whether there are adverse health effects of prenatal exposure long-term, low levels mercury and selenium. However, limited that reports on the association between by selenium birth size. Therefore, we examined maternal during pregnancy had any effect infant size, influenced this relationship.To examine with size.The Japan Environment Children's Study a prospective cohort conducted 2011 2014. Total total in blood second third trimesters were measured using...
Thyroid antibodies (TAs) are the most common cause of hypothyroidism during gestation. Although previous studies found that prenatal exposure to perfluoroalkyl substances (PFASs) disrupts thyroid hormones (THs) in humans, their effects on TAs perinatal period have not been investigated.To explore associations between eleven different PFASs from two groups (carboxylates and sulfonates) expression THs maternal cord blood while considering TA status.In a prospective birth cohort (the Hokkaido...
Exposure to phthalates and phosphorus flame retardants (PFRs) is considered be a risk factor for asthma allergies. However, little known about the contribution of loss-of-function mutations in gene encoding filaggrin (FLG) gene, which are predisposing factors eczema asthma, these associations. We investigated associations between exposure PFRs dust eczema/wheeze among Japanese children, taking into consideration FLG. This study was part Hokkaido on Environment Children's Health. Seven 11...
There have been inconsistent findings reported on maternal passive smoking during pregnancy and child risk of ADHD. In this study, ADHD symptoms at pre-school age children in association with prenatal active tobacco smoke exposure determined by plasma cotinine levels the third trimester were investigated.This was a follow-up study birth cohort: Hokkaido Study Environment Children's Health. Children whose parents answered Strengths Difficulties Questionnaire (SDQ) to identify...
Exposure to bisphenol A (BPA) in utero is associated with adverse health outcome of the offspring. Differential DNA methylation at specific CpG sites may link BPA exposure impacts. We examined association prenatal genome-wide changes cord blood 277 mother-child pairs Hokkaido Study on Environment and Children's Health, using Illumina HumanMethylation 450 BeadChip. observed that a large portion BPA-associated differentially methylated CpGs p-value < 0.0001 was hypomethylated among all...
Abstract Maternal smoking is reported to cause adverse effects on the health of unborn child, underlying mechanism for which thought involve alterations in DNA methylation. We examined maternal methylation cord blood, 247 mother–infant pairs Sapporo cohort Hokkaido Study, using Infinium HumanMethylation 450K BeadChip. first identified differentially methylated CpG sites with a false discovery rate (FDR) <0.05 and magnitude changes (|β| >0.02) from pairwise comparisons never-smokers...
Hypertension during pregnancy causes a greater risk of adverse birth outcomes worldwide; however, formal evidence hypertensive disorders (HDP) in Japan is limited. We aimed to understand the association between maternal characteristics, HDP, and outcomes. In total, 18,833 mother-infant pairs were enrolled Hokkaido study on environment children’s health, Japan, from 2002 2013. Medical records used identify outcomes, namely, small for gestational age (SGA), SGA at full term (term-SGA), preterm...
Objectives Multimorbidity is defined as the coexistence of two or more chronic physical psychological conditions within an individual. The association between maternal multimorbidity and adverse perinatal outcomes such preterm delivery low birth weight has not been well studied. Therefore, this study aimed to investigate association. Methods We conducted a prospective cohort using data from Japan Environment Children’s Study pregnant women 2011 2014. Those with on were included in...