A5054154742- Inflammatory Bowel Disease
- Birth, Development, and Health
- Immunodeficiency and Autoimmune Disorders
- Health, Environment, Cognitive Aging
- Per- and polyfluoroalkyl substances research
- Air Quality and Health Impacts
- Immune Cell Function and Interaction
- Heavy Metal Exposure and Toxicity
- Child Development and Digital Technology
- T-cell and B-cell Immunology
- Effects and risks of endocrine disrupting chemicals
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Helicobacter pylori-related gastroenterology studies
- IL-33, ST2, and ILC Pathways
- Cleft Lip and Palate Research
- Electromagnetic Fields and Biological Effects
- Systemic Lupus Erythematosus Research
- Chemical Analysis and Environmental Impact
- Toxic Organic Pollutants Impact
- Breastfeeding Practices and Influences
- Genetic Associations and Epidemiology
- Infant Health and Development
- Impact of Technology on Adolescents
- Tracheal and airway disorders
- Mercury impact and mitigation studies
Hokkaido University
2006-2025
Sapporo University
2018-2024
Center for Environmental Health
2018-2024
Shonan University of Medical Sciences
2024
Health Sciences University of Hokkaido
2021-2024
Chiba University
2022-2024
Adult Congenital Heart Association
2023
Kanazawa Medical University
2023
Shimane University
2023
RIKEN Center for Integrative Medical Sciences
2010-2022
The inflammatory bowel diseases (IBDs), Crohn's disease (CD) and ulcerative colitis, are chronic disorders of the digestive tract. pathogenesis IBD is complicated, it widely accepted that immunologic, environmental genetic components contribute to its etiology. To identify susceptibility factors in CD, we performed a genome-wide association study Japanese patients controls using nearly 80 000 gene-based single nucleotide polymorphism (SNP) markers investigated haplotype structure candidate...
The Hokkaido Study on Environment and Children's Health is an ongoing study consisting of two birth cohorts different population sizes: the Sapporo cohort cohort. Our primary goals are (1) to examine effects low-level environmental chemical exposures outcomes, including defects growth retardation; (2) follow development allergies, infectious diseases, neurobehavioral developmental disorders perform a longitudinal observation child development; (3) identify high-risk groups based genetic...
DNA polymorphisms in a region on chromosome 5q33.1 which contains two genes, immunity related GTPase family, M (IRGM) and zinc finger protein 300 (ZNF300), are associated with Crohn's disease (CD). The deleted allele of 20 kb copy number variation (CNV) upstream IRGM was recently shown to be strong linkage disequilibrium (LD) the CD-associated single nucleotide is itself CD (P < 0.01). deletion correlated increased or reduced expression transformed cells cell line-dependent manner, has been...
Abstract Background The Hokkaido Study on Environment and Children’s Health is an ongoing study consisting of two birth cohorts different population sizes: the Sapporo cohort cohort. Our primary objectives are to (1) examine effects that low-level environmental chemical exposures have outcomes, including defects growth retardation; (2) follow development allergies, infectious diseases, neurobehavioral developmental disorders, as well perform a longitudinal observation child development; (3)...
Abstract Background: Cytochrome P450 2D6 (CYP2D6), one of the most important drug-metabolizing enzymes, has been reported to possess variation in encoding CYP2D6 gene (cytochrome P450, family 2, subfamily D, polypeptide 6) that affects enzymatic activity. For pharmacogenetic study CYP2D6, accurate measurement dosage functional is essential; however, current genotyping techniques are insufficient because their inability provide exact copy number genes. Methods: We developed 3 quantitative...
A large-scale meta-analysis of a series European genome-wide association studies revealed 71 susceptibility loci for Crohn's disease (CD). However, it is not clear whether these are also shared with Japanese populations.We genotyped single-nucleotide polymorphisms (SNPs) comprising 1311 CD cases and 6585 controls descent, their associations were evaluated using the Cochran-Armitage trend test. In addition, genotype-phenotype analyses conducted on SNPs showing based Montreal...
Genotype imputation of the human leukocyte antigen (HLA) region is a cost-effective means to infer classical HLA alleles from inexpensive and dense SNP array data. In research setting, helps avoid costs for wet lab-based typing thus renders association analyses in large cohorts feasible. Yet, most reference panels target Caucasian ethnicities multi-ethnic are scarce. We compiled high-quality panel based on genotypes measured with Illumina's Immunochip genotyping types established using...
It is necessary to determine whether there are adverse health effects of prenatal exposure long-term, low levels mercury and selenium. However, limited that reports on the association between by selenium birth size. Therefore, we examined maternal during pregnancy had any effect infant size, influenced this relationship.To examine with size.The Japan Environment Children's Study a prospective cohort conducted 2011 2014. Total total in blood second third trimesters were measured using...
Thyroid antibodies (TAs) are the most common cause of hypothyroidism during gestation. Although previous studies found that prenatal exposure to perfluoroalkyl substances (PFASs) disrupts thyroid hormones (THs) in humans, their effects on TAs perinatal period have not been investigated.To explore associations between eleven different PFASs from two groups (carboxylates and sulfonates) expression THs maternal cord blood while considering TA status.In a prospective birth cohort (the Hokkaido...
<h3>Background and aims:</h3> A number of genome-wide association studies have been performed as a robust means identifying susceptibility loci for Crohn's disease (CD). The detected after the completion HapMap project are quite concordant among these studies, suggesting that results reliable. Recently, Wellcome Trust Case Control Consortium (WTCCC) reported primary scanning 17 000 individuals seven diseases, including CD, subsequent study has validated susceptible genetic variants in...
Studies reported adverse behavioral development including internalizing and externalizing problems in association with prenatal exposure to bisphenol A (BPA) phthalates; however, findings were not sufficient due using different assessment tools child ages among studies. This study aimed examine associations between maternal serum levels of BPA phthalate metabolites at preschool age.The Strengths Difficulties Questionnaire (SDQ) was used assess 5 years age. metabolite the first trimester...
There have been inconsistent findings reported on maternal passive smoking during pregnancy and child risk of ADHD. In this study, ADHD symptoms at pre-school age children in association with prenatal active tobacco smoke exposure determined by plasma cotinine levels the third trimester were investigated.This was a follow-up study birth cohort: Hokkaido Study Environment Children's Health. Children whose parents answered Strengths Difficulties Questionnaire (SDQ) to identify...
Streptococcus infection is a common and potentially severe bacterial which remains global public health challenge, underscoring the necessity of investigating potential risk factors. The present study aims to assess association between metal trace element exposure using prospective nationwide birth cohort, Japan Environment Children's Study (JECS). JECS obtained data from over 100,000 pregnancies through 15 Regional Centres across Japan. We assessed toxic levels among pregnant mothers their...
Although per- and polyfluoroalkyl substances (PFAS) have raised global concern due to their adverse effects on children's development, the association between prenatal exposure PFAS achievement of developmental milestones in preschool children remains unclear. This study aimed examine individual cumulative associations delay 4-year-old children. We used data from 15,131 mothers (15,175 children) Japan Environment Children Study (JECS), an ongoing nationwide prospective birth cohort. Among 28...