A5100769585- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Peptidase Inhibition and Analysis
- Cardiac Imaging and Diagnostics
- Pharmacological Receptor Mechanisms and Effects
- Cancer Research and Treatments
- Advanced MRI Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Click Chemistry and Applications
- Receptor Mechanisms and Signaling
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Neuropeptides and Animal Physiology
- Marine Bivalve and Aquaculture Studies
- Biochemical and Structural Characterization
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Supramolecular Self-Assembly in Materials
- Advanced Nanomaterials in Catalysis
- Cancer therapeutics and mechanisms
- Drug Transport and Resistance Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Colorectal Cancer Treatments and Studies
Beijing Normal University
2014-2025
Huazhong University of Science and Technology
2006-2025
Tongji Hospital
2017-2025
Sun Yat-sen University
2022-2024
Sun Yat-sen University Cancer Center
2022-2024
State Key Laboratory of Oncology in South China
2022
Shandong Provincial QianFoShan Hospital
2019-2021
Shandong First Medical University
2015-2021
Southern Medical University
2020
Nanfang Hospital
2020
An anthelminthic, pyrvinium pamoate (PP), 6‐(dimethylamino)‐2‐[2‐(2,5‐dimethyl‐1‐phenyl‐1 H ‐pyrrol‐3‐yl)ethenyl]‐1‐methyl‐quino‐linium salt, has been found to be extremely toxic PANC‐1 cells in glucose‐free medium, but not the same cultured ordinary Dulbecco's modified Eagle's medium (DMEM). It showed preferential toxicity for various cancer cell lines during glucose starvation. When 0.1 μg/ml PP was added spheroid growth of human colon line WiDr strongly inhibited a diameter 750 μm, and...
With the development of PD-1/PD-L1 immune checkpoint inhibitor therapy, ability to monitor PD-L1 expression in tumor microenvironment is important for guiding therapy. This study was performed develop a novel radiotracer with optimal pharmacokinetic properties reflect vivo via single-photon emission computed tomography (SPECT) imaging. [99mTc]Tc-HYNIC-WL12-tricine/M (M = TPPTS, PDA, ISONIC, 4-PSA) complexes high radiochemical purity (>97%) and suitable molar activity (from 100.5 GBq/μmol...
ABSTRACT This study reports the automated radiosynthesis and evaluation of [ 18 F]FPMBBG, a radiopharmaceutical designed to target norepinephrine transporter (NET). A newly developed fully protected benzylguanidine precursor, which prevents interference from non‐protected part during nucleophilic process, has enabled one‐pot two‐step cassette‐based synthesis F]FPMBBG. advancement enhances feasibility synthesis, ensures reproducibility, allows for production substantial quantities...
Abstract Objectives To report a rare case of jelly-like urine associated with urinary tract infection (UTI) and to review relevant literature on its potential causes clinical significance. Case Presentation An 81-year-old male patient presented lower abdominal discomfort urethral meatal pain. Urinalysis revealed yellow, high viscosity, accompanied by significant increase in white blood cells, red bacterial counts. Additional tests confirmed diagnosis UTI, cystitis renal function...
Various microorganisms were screened for their ability to desulfurize dibenzothiophene (DBT) via a sulfur-specific pathway. Based on the desulfurization activity, strain G3 was selected as best strain. From taxonomical studies, shown belong genus Mycobacterium. Dibenzothiophene degraded by both growing and resting cells of this strain, 2-hydroxybiphenyl detected dead-end product. Strain could also 4,6-dimethylDBT. Sulfate ion repressed expression DBT desulfurizing enzyme(s). Accumulation...
To develop radiolabeled FGFR2-targeting probes for visualizing fibroblast growth factor receptor (FGFR) expression levels in the tumor microenvironment, four novel 99mTc-labeled peptides ([99mTc]Tc-FGFR2-1, [99mTc]Tc-FGFR2-2, [99mTc]Tc-FGFR2-3, and [99mTc]Tc-FGFR2-4) with different amino acid linkers between targeted peptide moiety 99mTc chelating group were designed synthesized. The vitro cellular inhibition, internalization, efflux results demonstrated that complexes exhibited...
We have designed and synthesized novel piperazine compounds with low lipophilicity as σ1 receptor ligands. 1-(4-Fluorobenzyl)-4-[(tetrahydrofuran-2-yl)methyl]piperazine (10) possessed a nanomolar affinity high selectivity toward the vesicular acetylcholine transporter (>2000-fold), σ2 receptors (52-fold), adenosine A2A, adrenergic α2, cannabinoid CB1, dopamine D1, D2L, γ-aminobutyric acid A (GABAA), NMDA, melatonin MT1, MT2, serotonin 5-HT1 receptors. The corresponding radiotracer [18F]10...
The purpose of this study was to develop novel radiolabeled gonadotropin-releasing hormone (GnRH) receptor-targeting peptides for breast cancer imaging. Three 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-conjugated GnRH were designed and synthesized. radiometal chelator DOTA conjugated the epsilon or alpha amino group d-lysine, l-lysine via an Ahx {aminohexanoic acid} linker generate DOTA–Ahx–(d-Lys6-GnRH1), DOTA–Ahx–(d-Lys6-GnRH2) DOTA–Ahx–(l-Lys6-GnRH3), respectively....
We report the design, synthesis, and evaluation of a series novel cyclopentadienyl tricarbonyl (99m)Tc complexes as potent σ1 receptor radioligands. Rhenium compounds 3-(4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl)propylcarbonylcyclopentadienyl rhenium (10a) 4-(4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl)butylcarbonylcyclopentadienyl (10b) possessed high in vitro affinity for receptors moderate to selectivity σ2 vesicular acetylcholine transporter. Biodistribution studies mice demonstrated...
Lipophilic cations such as phosphonium salts can accumulate in mitochondria of heart response to the negative inner-transmembrane potentials. Two [18F]FMBTP and [18F]mFMBTP were prepared evaluated potential myocardial perfusion imaging (MPI) agents this study. The radiolabeled via a simplified one-pot method starting from [18F]fluoride followed by physicochemical property tests, vitro cellular uptake assay, ex vivo mouse biodistribution, rat microPET imaging. total radiosynthesis time was...
A 37 residue peptide, aglycin, has been purified from porcine intestine. The sequence is identical to that of residues 27–63 plant albumin 1 B precursor (PA1B, chain b) pea seeds. Aglycin resists in vitro proteolysis by pepsin, trypsin and Glu‐C protease, compatible with its intestinal occurrence an exogenous origin food. When subcutaneously injected into mice (at 10 µg·g −1 body weight), aglycin a hyperglycemic effect resulting doubling the blood glucose level within 60 min. Using surface...
The measurement of catecholamines in human body fluids is requested frequently for the differential diagnosis and monitoring pheochromocytoma. methods most clinical laboratories focus on high-performance liquid chromatography coupled with electrochemical detection, which suffers from high background noise, low sensitivity, poor separation. We reported developed a robust high-throughput tandem mass spectrometry method routine urinary was validated consistent linearity, good recovery...
The chemokine receptor 4 (CXCR4) has been an attractive molecular target for tumor imaging, because it is overexpressed in many types and involved progression metastasis. purpose of this study to examine the CXCR4 targeting properties 99m Tc‐labeled AMD3465, a small molecule antagonist CXCR4. Tc‐AMD3465 was prepared high yield (>95%) stable mice serum at least hours. In vitro cell binding experiments were performed with Chinese hamster ovary (CHO), MCF‐7 (breast cancer), CHO‐CXCR4 (CHO...
Supramolecular materials assembled by amide-functionalized surface active ionic liquid, N-dodecyl-N′-acetamido imidazolium bromide ([C12ImCONH2]Br), and europium-containing polyoxometalates (Eu-POM) were fabricated in aqueous solution a one-step method via self-assembly strategy. The [C12ImCONH2]Br/Eu-POM supramolecular structures exhibit favorable fluorescence properties represent 15-fold increase quantum yield (∼13.68%) compared to Eu-POM. Besides, more was quenched obviously with the...