A5079627298- Pharmacological Receptor Mechanisms and Effects
- Receptor Mechanisms and Signaling
- Radiopharmaceutical Chemistry and Applications
- Neuropeptides and Animal Physiology
- Alzheimer's disease research and treatments
- Medical Imaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Lanthanide and Transition Metal Complexes
- Transportation Planning and Optimization
- Synthesis and Biological Evaluation
- Cancer, Stress, Anesthesia, and Immune Response
- Peptidase Inhibition and Analysis
- Vehicle Routing Optimization Methods
- Medical Imaging and Pathology Studies
- Transportation and Mobility Innovations
- Fungal Biology and Applications
- Traffic Prediction and Management Techniques
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Chemical Synthesis and Analysis
- Lipid metabolism and disorders
- Axial and Atropisomeric Chirality Synthesis
Beijing Normal University
2016-2025
Hengshui University
2025
Chengdu University of Traditional Chinese Medicine
2024
Jiangsu University
2021-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2022
Texas A&M University – Commerce
2021
TED University
2011-2013
North China University of Science and Technology
2011-2013
Tangshan College
2012-2013
Hebei University
2012
Accurate predicting the yield and quality of medicinal materials before harvest can effectively guide post-harvest process, including processing storage, thereby ensuring final materials. Currently, traditional experimental methods for estimation are inadequate to offer reliable guidance harvesting plan. Uncrewed aerial vehicle (UAV) multispectral quickly accurately estimate field crops. Based on UAV data Ligusticum chuanxiong Hort. obtained about half a month near harvest, this study...
Rhenium and technetium-99m cyclopentadienyl tricarbonyl complexes mimicking the chalcone structure were prepared. These proved to have affinity β-amyloid (Aβ) in fluorescent staining on brain sections of Alzheimer's Disease (AD) patient binding assay using Aβ(1-42) aggregates, with K(i) values ranging from 899 108 nM as extension conjugated π system. In vitro autoradiograpy transgenic mouse confirmed [(99m)Tc]5 (K(i) = nM). biodistribution, all compounds showed good initial uptakes into fast...
A series of fluoro-pegylated (FPEG) 2-pyridinylbenzoxazole and 2-pyridinylbenzothiazole derivatives were synthesized evaluated as novel β-amyloid (Aβ) imaging probes for PET. They displayed binding affinities Aβ1–42 aggregates that varied from 2.7 to 101.6 nM. Seven ligands with high affinity selected 18F labeling. In vitro autoradiography results confirmed the these radiotracers. vivo biodistribution experiments in normal mice indicated radiotracers a short FPEG chain (n = 1) initial uptake...
Vehicle Routing Problems have very important applications in the area of distribution management. VRP is both theoretical and practical interest (due to its real world applications), which explains amount attention given by researchers past years, since an NP-Hard problems. In this paper, we designed realized a new Tabu Search introducing mutation mixed local searching tactics for overcoming weaknesses current TS. Here are concerned with algorithm strategies parameters how they affect...
We have designed and synthesized novel piperazine compounds with low lipophilicity as σ1 receptor ligands. 1-(4-Fluorobenzyl)-4-[(tetrahydrofuran-2-yl)methyl]piperazine (10) possessed a nanomolar affinity high selectivity toward the vesicular acetylcholine transporter (>2000-fold), σ2 receptors (52-fold), adenosine A2A, adrenergic α2, cannabinoid CB1, dopamine D1, D2L, γ-aminobutyric acid A (GABAA), NMDA, melatonin MT1, MT2, serotonin 5-HT1 receptors. The corresponding radiotracer [18F]10...
Mass customization (MC), as a completely new product mode; combine the advantages of both mass production and customized production. MC provides which satisfies increased consumer awareness quality functionality demands with low cost short lead time. Obviously garment industry necessary commodities. On other hand these goods include diverse fashionable elements, thus end customers have various choices among brands, drapes, fabrics colours. This paper will explore how mode integrates...
<sup>99m</sup>Tc-labeled probes in this study for the Aβ plaques blood vessels of brain may be used as SPECT imaging agents diagnosis CAA.
Direct bromination of the tyrosine residues peptides and antibodies with bromine-76, to create probes for PET imaging, has been reported. For that do not contain residues, however, a prosthetic group is required achieve labeling via conjugation other functional groups such as terminal α-amines or lysine ε-amines. The goal this study was develop new strategies small Br-76 using either direct method group, depending on available peptides. A agent,...
A series of spirocyclic piperidine derivatives were designed and synthesized as σ1 receptor ligands. In vitro competition binding assays showed that 1′-(4-(2-fluoroethoxy)benzyl)-3H-spiro[2-benzofuran-1,4′-piperidine] (19) possessed high affinity (Ki = 0.79 nM) excellent σ1/σ2 subtype selectivity (350-fold) well σ1/VAChT (799-fold). The radiolabeled compound [18F]19 was by substitution the tosylate precursor 24 with [18F]fluoride, an isolated radiochemical yield 35–60%, a purity >99%,...
We report the design, synthesis, and evaluation of a series novel cyclopentadienyl tricarbonyl (99m)Tc complexes as potent σ1 receptor radioligands. Rhenium compounds 3-(4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl)propylcarbonylcyclopentadienyl rhenium (10a) 4-(4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl)butylcarbonylcyclopentadienyl (10b) possessed high in vitro affinity for receptors moderate to selectivity σ2 vesicular acetylcholine transporter. Biodistribution studies mice demonstrated...
The σ<sub>1</sub> receptors (S1Rs) are implicated in a variety of diseases including Alzheimer disease and cancer. Previous PET S1R radiotracers characterized by slow kinetics or off-target binding that impedes their use humans. Here, we report the first imaging evaluation rhesus monkeys 4 <sup>18</sup>F-labeled spirocyclic piperidine-based (<sup>18</sup>F-<b>1</b> to <sup>18</sup>F-<b>4</b>). <b>Methods:</b> Baseline scans for were obtained on an adult male monkey. Blocking with...
We report the syntheses and evaluation of series novel piperidine compounds with low lipophilicity as σ1 receptor ligands. 8-(4-(2-Fluoroethoxy)benzyl)-1,4-dioxa-8-azaspiro[4.5]decane (5a) possessed high affinity (K(i) = 5.4 ± 0.4 nM) for receptors selectivity σ2 (30-fold) vesicular acetylcholine transporter (1404-fold). [(18)F]5a was prepared using a one-pot, two-step labeling procedure in an automated synthesis module, radiochemical purity >95%, specific activity 25-45 GBq/μmol. Cellular...
We have designed and synthesized a series of cyclopentadienyl tricarbonyl rhenium complexes containing 5,6-dimethoxyisoindoline or 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline pharmacophore as σ2 receptor ligands. Rhenium compound 20a possessed low nanomolar affinity (K(i) = 2.97 nM) moderate subtype selectivity (10-fold). Moreover, it showed high toward vesicular acetylcholine transporter (2374-fold), dopamine D2L receptor, NMDA opiate transporter, norepinephrine serotonin transporter. Its...