A5100703930- Cancer Treatment and Pharmacology
- Traditional Chinese Medicine Studies
- Chemotherapy-related skin toxicity
- Pain Mechanisms and Treatments
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Cardiac Imaging and Diagnostics
- Diabetes Treatment and Management
- Traditional Chinese Medicine Analysis
- Trace Elements in Health
- Insect and Pesticide Research
- Oceanographic and Atmospheric Processes
- Intracranial Aneurysms: Treatment and Complications
- Lipid metabolism and disorders
- Heavy Metal Exposure and Toxicity
- Renal and Vascular Pathologies
- Family and Disability Support Research
- Plant-based Medicinal Research
- Monoclonal and Polyclonal Antibodies Research
- Plant and animal studies
- Medical Imaging and Pathology Studies
- Neonatal and fetal brain pathology
- Retinal and Optic Conditions
- Pediatric Urology and Nephrology Studies
- Acute Myocardial Infarction Research
Hunan University of Traditional Chinese Medicine
2015-2024
Chongqing Public Health Medical Center
2023
Chongqing Medical University
2023
Nanjing Audit University
2022
Nanjing University
2022
Shanxi Provincial Children's Hospital
2021
Nanjing University of Chinese Medicine
2019-2020
Johns Hopkins University
2020
Johns Hopkins Medicine
2020
Hunan University
2018
Chemotherapy-induced peripheral neuropathy (CIPN) is a severe, toxic side effect that frequently occurs in anticancer treatment and may result discontinuation of as well serious reduction life quality. The CIPN incidence rate high 85%-90%. Unfortunately, there currently no standard evidence-based treatment. In several clinical trials, it has been reported duloxetine can improve pain induced by oxaliplatin (OXA) paclitaxel (PTX); thus, American Society Clinical Oncology (ASCO) recommends the...
Paclitaxel (PTX) is an antineoplastic drug extracted from the <i>Taxus</i> species, and peripheral neuropathy a common side effect. Paclitaxel-induced (PIPN) seriously affects patient quality of life. Currently, mechanism PIPN still unknown, few treatments are recognized clinically. Duloxetine recommended as only potential treatment chemotherapy-induced (CIPN) by American Society Clinical Oncology. However, this guidance lacks theoretical basis experimental evidence. Our study suggested that...
Paclitaxel, a commonly used chemotherapeutic agent, is usually associated with peripheral neuropathy. Paclitaxel induced neuropathy (PIPN) can be dose limiting and may have detrimental influence on patients' quality of life. However, the mechanism PIPN remains unclear. Medicinal herbs their formulas might offer neuronal protection multitarget integrated benefits in chemotherapy-induced (CIPN). Siwei Jianbu decoction (J12) classic formula traditional Chinese medicine which promote blood...
Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect caused by chemotherapy drugs, and its existence seriously affects the quality of life patients. We first established an oxaliplatin-induced (OIPN) model then measured evaluated mechanical hyperalgesia, thermal nociception, cold allodynia, intraepidermal nerve fiber (IENF) density to determine Siwei Jianbu Decoction’s role in preventing OIPN. Then, we conducted systematic pharmacological study that revealed...
Compound 6c was a potent DPP-4 inhibitor designed and synthesized by our group. Previous study indicated that compound had long terminal half time could be administrated once week. In vitro in vivo biological evaluation showed good antidiabetic activity. For further development, more pharmacokinetic behavior needed to investigated. this paper, rapid sensitive method for the quantification of UPLC-MS/MS established validated. Chromatographic separation achieved an Exsil Mono C18 (50 mm * 2...
Background: Diabetic macular edema (DME) is the main cause of irreversible vision loss in patients with diabetes mellitus (DM), resulting a certain burden to and society. With increasing incidence DME, more researchers are focusing on it. Methods: The papers related DME between 2012 2022 from Web Science core Collection were searched this study. Based CiteSpace VOS viewer, these publications analyzed terms spatiotemporal distribution, author subject classification, topic citations. Results:...
The study focused on the application value of ultrasound Doppler fetal heart rate detection algorithm based short-time Fourier transform (STFT) in diagnosis twin-to-twin selective intrauterine growth restriction (sIUGR) and correlation between sIUGR sFas/sFasL levels umbilical cord blood. normalized method was introduced into STFT to optimize it detect instantaneous rate. 82 pregnant women with twin pregnancies were selected as research subjects they divided restricted group (41 cases)...