A5047243131- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Peptidase Inhibition and Analysis
- Advanced Neuroimaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- Medical Imaging Techniques and Applications
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Neuropeptides and Animal Physiology
- Pharmacological Receptor Mechanisms and Effects
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Protease and Inhibitor Mechanisms
- RNA modifications and cancer
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Hematological disorders and diagnostics
- Prostate Cancer Treatment and Research
- Advanced MRI Techniques and Applications
- Diet and metabolism studies
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
Huashan Hospital
2017-2025
Fudan University
2016-2025
South China Agricultural University
2022-2025
Nanjing Medical University
2024-2025
Nanjing University
2024-2025
Nanjing General Hospital of Nanjing Military Command
2024-2025
Nanjing University of Chinese Medicine
2025
Nanfang Hospital
2024
Shanghai Jiao Tong University
2013-2024
Ruijin Hospital
2010-2024
MicroRNAs (miRNAs), which regulate gene expression by partial complementarity to the 3' untranslated region of their target genes, have been implicated in cancer initiation and progression. However, molecular mechanism underlying regulation miRNA during pancreatic tumorigenesis has not extensively reported. In this study, we first compared human cancers adjacent normal tissues array identified 12 differentially expressed miRNAs. miR-132, is downregulated tumors, was further studied greater...
Background Fibroblast activation protein (FAP) is commonly expressed in activated stromal fibroblasts various epithelial tumours. Recently, 68 Ga-FAPI-04 has been used for tumour imaging positron emission tomography/computed tomography (PET/CT). This study aimed to compare the diagnostic performances of PET/CT and 18 F-FDG hepatocellular carcinoma (HCC), assess factors associated with uptake HCC. Materials Methods Twenty-nine patients suspiciously HCC who received both were included this...
Synapse loss has been considered as a major pathological change in Alzheimer’s disease (AD). It remains unclear about whether and how synapse relates to functional structural connectivity dysfunction AD. We measured synaptic vesicle glycoprotein 2 A (SV2A) binding using 18 F-SynVesT-1 PET evaluate alterations 33 participants with AD, 31 mild cognitive impairment (MCI), 30 controls. examined the correlation between density function. Functional MRI was performed analyze lower regions. tracked...
Abstract Accurately predicting and selecting patients who can benefit from targeted or immunotherapy is crucial for precision therapy. Trophoblast cell surface antigen 2 (Trop2) has been extensively investigated as a pan-cancer biomarker expressed in various tumours plays role tumorigenesis through multiple signalling pathways. Our laboratory successfully developed two 68 Ga-labelled nanobody tracers that rapidly specifically target Trop2. Of the tracers, [ Ga]Ga-NOTA-T4, demonstrated...
The metabolic implications in Alzheimer's disease (AD) remain poorly understood. Here, we conducted a metabolomics study on moderately aging Chinese Han cohort (n = 1397; mean age 66 years). Conjugated bile acids, branch-chain amino acids (BCAAs), and glutamate-related features exhibited strong correlations with cognitive impairment, clinical stage, brain amyloid-β deposition 421). These demonstrated synergistic performances across stages subpopulations enhanced the differentiation of AD...
Abstract INTRODUCTION We aimed to investigate the effect of apolipoprotein E4 ( APOE) ε4 on synaptic density in cognitively impaired (CI) participants. METHODS One hundred ten CI participants underwent amyloid positron emission tomography (PET) with 18 F‐florbetapir and PET F‐SynVesT‐1. evaluated influence APOE allele investigated effects genotype associations Alzheimer's disease (AD) biomarkers. The mediation AD biomarkers ε4‐associated loss were analyzed. RESULTS Compared non‐carriers,...
Metabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5 signaling relevant failure play a key role the initial pathophysiological mechanism of Alzheimer's disease (AD). The study aims to investigate association between availability AD's biomarkers cognitive function.
A newly developed SV2A radiotracer, 18 F-SynVesT-1, was used in this study to investigate synaptic density and its association with Alzheimer’s disease (AD) “A/T/N” biomarkers. The included a cohort of 97 subjects, consisting 64 patients cognitive impairment (CI) 33 individuals normal cognition (CU). All subjects underwent F-SynVesT-1 PET/MR F-florbetapir PET/CT scans. Additionally, subgroup also F-MK-6240, F-FDG PET/CT, plasma Aβ42/Aβ40 p-tau181 tests. differences between the groups...
Metabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5 signaling relevant failure play a key role the pathophysiological mechanism of Alzheimer's disease (AD).
We investigated the association between white matter hyperintensities (WMH) and regional cortical thickness, amyloid tau deposition, synaptic density in WMH-connected cortex using multimodal images.
Background The current research was to investigate the relationship between prognostic nutritional index (PNI) and mortality, with a focus on all-cause cardiovascular disease (CVD) for those non-alcoholic fatty liver (NAFLD). Methods Data from 20,142 patients who participated in National Health Nutrition Examination Survey (NHANES), which carried out 2005 2014, were included this research. To examine PNI both we employed weighted Cox regression models multiple variables. Kaplan–Meier...
Various indicators of neurodegeneration (N) are used in the assessment neuronal injury Alzheimer's disease (AD). The heterogeneity such is less clear. A total 416 individuals with different cognitive statuses were recruited for this study. Differential associations hippocampal volume (HV), 18F-fluorodeoxyglucose positron emission tomography (FDG PET) standardized uptake value ratios (SUVRs), and plasma neurofilament light chain (NfL) levels amyloid beta (Aβ)-tau pathology impairment...
// Junyun Wang 1,2,* , Nan Ding Yongjun Li 1,* Hua Cheng 3,* Dong 4 Qiong Yang 1,2 Youhui Deng Yaran 1 Yanming Xiuyan Ruan Fang Xie Zhao and Xiangdong CAS Key Laboratory of Genome Sciences Information, Beijing Institute Genomics, Chinese Academy Sciences, Beijing, China 2 University 3 Biology, Hebei Shijiazhuang, Department Dermatology, General Hospital People's Liberation Army, * These authors have contributed equally to this work Correspondence to: Fang, email: Zhao, Keywords : IGFBP5;...
BackgroundGenomic aberrations have been identified in metastatic castration-resistant prostate cancer (mCRPC), but molecular predictors of resistance to abiraterone acetate/prednisone (AA/P) treatment are not known.Patients and methodsIn a prospective clinical trial, mCRPC patients underwent whole-exome sequencing (n = 82) RNA 75) biopsies before initiating AA/P with the objective identifying genomic alterations associated AA/P. Primary was determined at 12 weeks using criteria for...
Abstract Objectives Transfusional iron overload is of major concern in hematological disease. Iron‐overload‐related dyserythropoiesis and reactive oxygen species (ROS)‐related damage to hematopoietic stem cell (HSC) function are setbacks treatment for such disorders. We therefore aim investigate the effect on hematopoiesis patients explore role ROS iron‐induced oxidative cells microenvironment vitro . Patients methods The colony‐forming capacity level bone marrow were tested before after...
Reactive astrocytes play an important role in the development of Alzheimer's disease (AD). Here, we aimed to investigate temporospatial relationships among monoamine oxidase-B, tau and amyloid-β (Aβ), translocator protein, glucose metabolism by using multitracer imaging AD transgenic mouse models. Positron emission tomography (PET) with [
<h3>Background</h3> Graves' disease is a female preponderant autoimmune illness and the contribution of X chromosome to its risk has long been appreciated. However, no X-linked susceptibility loci have indentified from recent genome-wide association studies (GWAS). <h3>Methods</h3> We re-examined data our GWAS for by including males that were previously excluded analyses. The analysed using logistic regression analysis sex as covariate, an additive method assuming inactivation, implemented...
Abstract Genetic risks in breast cancer remain only partly understood. Here, we report the results of a genome-wide association study germline DNA from 4,658 women, including 252 women experiencing recurrence, who were entered on MA.27 adjuvant trial comparing aromatase inhibitors (AI) anastrozole and exemestane. Single-nucleotide polymorphisms (SNP) top significance identified gene encoding MIR2052HG, long noncoding RNA unknown function. Heterozygous or homozygous individuals for variant...
Type 2 diabetes mellitus (T2DM) is associated with a greater risk of Alzheimer's disease. Synaptic impairment and protein aggregates have been reported in the brains T2DM models. Here, we assessed whether neurodegenerative changes synaptic vesicle A (SV2A), γ-aminobutyric acid type (GABA