A5101516344- Metabolomics and Mass Spectrometry Studies
- Drug Transport and Resistance Mechanisms
- Gut microbiota and health
- Bioinformatics and Genomic Networks
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Trace Elements in Health
- Gene expression and cancer classification
- Osteoarthritis Treatment and Mechanisms
- Pelvic floor disorders treatments
- Mass Spectrometry Techniques and Applications
- Microbial infections and disease research
- Hepatitis B Virus Studies
- Advanced Combustion Engine Technologies
- Animal Virus Infections Studies
- Seismology and Earthquake Studies
- Clostridium difficile and Clostridium perfringens research
- Biodiesel Production and Applications
- Peroxisome Proliferator-Activated Receptors
- Genomics and Phylogenetic Studies
- Cytokine Signaling Pathways and Interactions
- Inflammatory mediators and NSAID effects
- Hepatitis C virus research
- Amino Acid Enzymes and Metabolism
- Fibroblast Growth Factor Research
Shanghai Sixth People's Hospital
2021-2024
Shanghai Jiao Tong University
2015-2024
China Medical University
2024
First Hospital of China Medical University
2024
Institute of Computing Technology
2024
Chinese Academy of Sciences
2024
University of Shanghai for Science and Technology
2020
Liaoning Cancer Hospital & Institute
2016
Breast cancer (BC) is still a lethal threat to women worldwide. An accurate screening and diagnosis strategy performed in an easy-to-operate manner highly warranted clinical perspective. Besides the routinely focused protein markers, blood full of small molecular metabolites with diverse structures properties. This study aimed screen metabolite markers BC potentials.A dried spot-based direct infusion mass spectrometry (MS) metabolomic analysis was conducted for non-BC differentiation. The...
Cognitive impairment in the elderly is associated with alterations bile acid (BA) metabolism. In this study, we observe elevated levels of serum conjugated primary acids (CPBAs) and ammonia individuals, mild cognitive impairment, Alzheimer's disease, aging rodents, a more pronounced change females. These changes are correlated increased expression ileal apical sodium-bile transporter (ASBT), hippocampal synapse loss, brain CPBA rodents. vitro experiments confirm that CPBA, taurocholic acid,...
The metabolic implications in Alzheimer's disease (AD) remain poorly understood. Here, we conducted a metabolomics study on moderately aging Chinese Han cohort (n = 1397; mean age 66 years). Conjugated bile acids, branch-chain amino acids (BCAAs), and glutamate-related features exhibited strong correlations with cognitive impairment, clinical stage, brain amyloid-β deposition 421). These demonstrated synergistic performances across stages subpopulations enhanced the differentiation of AD...
A significant increase of bile acid (BA) levels has been recognized as a general metabolic phenotype diverse liver diseases. Monitoring BA profiles proposed for etiology differentiation on injury. Here, we quantitatively profiled serum BAs healthy controls and 719 patients with chronic disease five etiologies, hepatitis B virus (HBV), C (HCV), nonalcoholic steatohepatitis (NASH), alcohol-induced (ALD), primary biliary cirrhosis (PBC), investigated the generality specificity different...
The onset and progression of chronic liver disease (CLD) is a multistage process spanning years or several decades. Some bile acid (BA) features are identified as indicators for CLD progression. However, BAs highly influenced by various factors stage and/or population specific. Emerging evidences demonstrated the association structure conjugated Here, we aimed to investigate alteration identify new progression.Based on liquid chromatography-mass spectrometry platform, 15 were quantified in...
Abstract Bile acids (BAs) play important pathophysiological roles in both humans and mammalian animals. Laboratory rats mice are widely used animal models for assessing pharmacological effects their underlying molecular mechanisms. However, substantial physiological differences exist BA composition between murine rodents. Here, we comprehensively compare profiles, including primary secondary BAs, along with amino acid conjugates, sulfated metabolites serum, urine, feces two We further...
Abstract Sex disparities in serum bile acid (BA) levels and Alzheimer's disease (AD) prevalence have been established. However, the precise link between changes BAs AD development remains elusive. Here, authors quantitatively determined 33 58 BA features 4 219 samples collected from 1 180 participants Disease Neuroimaging Initiative. The findings revealed that these exhibited significant correlations with clinical stages, encompassing cognitively normal (CN), early late mild cognitive...
Metabolomics data analysis depends on the utilization of bioinformatics tools. To meet evolving needs metabolomics research, several integrated platforms have been developed. Our group has developed a desktop platform IP4M (integrated Platform for Data Analysis) which allows users to perform nearly complete in one-stop. With extensive usage IP4M, more and demands were raised from worldwide web version customized workflow. Thus, iMAP Analysis Platform) was with extended functions, improved...
Non-alcoholic fatty liver disease (NAFLD) is one of the main causes fibrosis. Liver biopsy remains gold standard for confirmation fibrosis in NAFLD patients. Effective and non-invasive diagnosis advanced essential to surveillance treatment decisions. Herein we used routine medical test markers logistic regression differentiate early patients from China, Malaysia, India ( n 1 = 540, 2 147, 3 97) who were confirmed by biopsy. Nine parameters, including age, body mass index, fasting blood...
The metabolome and microbiome disorders are highly associated with human health, there great demands for dual-omics interaction analysis. Here, we designed developed an integrative platform, 3MCor, correlation analysis under the instruction of phenotype consideration confounders.Many traditional novel methods were integrated intra- inter-correlation Three pipelines provided global, hierarchical pairwise incorporated network function is conducive to rapid identification clusters key nodes...
Abstract Given the pivotal roles of metabolomics and microbiomics, numerous data mining approaches aim to uncover their intricate connections. However, complex many‐to‐many associations between metabolome‐microbiome profiles yield statistically significant but biologically unvalidated candidates. To address these challenges, we introduce BiOFI, a strategic framework for identifying correlation pairs (Bi‐Omics). BiOFI employs comprehensive scoring system, incorporating intergroup differences,...
Abstract Background Microbiomic research has grown in popularity recent decades. The widespread use of next-generation sequencing technologies, including 16S rRNA gene-based and metagenomic shotgun-based methods, produced a wealth microbiome data. At present, most software analysis workflows for processing microbiomic data are command line-based, which requires considerable computing time makes interaction difficult. Results To provide command-line free, integrated, user interface friendly...
Abstract INTRODUCTION There is evidence that there are differences in the serum levels of bile acids (BAs) males and females their risk developing Alzheimer’s disease (AD). We previously reported BAs associated with AD. It remains unclear, however, how changes may relate to development AD a sex-dependent manner. METHODS analyzed 33 sera 4219 samples from 1180 subjects ADNI cohort. Using linear models, we examined associations between mild cognitive impairment (MCI) progression clinical...
Abstract Background: Mounting evidences have shown that microbiome and metabolome are closely linked to human health dual-omics studies expanded our knowledge understanding of life. Here, we designed developed a full-function easy-to-use platform, 3MCor (http://3mcor.cn/), for correlation analysis under the instruction phenotype with consideration confounders. Results: Many traditional newly reported methods were integrated intra- inter-correlation analysis. Three pipelines provided global,...