A5059197002- Nanoparticles: synthesis and applications
- Cancer-related molecular mechanisms research
- Anesthesia and Neurotoxicity Research
- Metabolomics and Mass Spectrometry Studies
- Advanced Nanomaterials in Catalysis
- Glycosylation and Glycoproteins Research
- Gut microbiota and health
- Monoclonal and Polyclonal Antibodies Research
- Galectins and Cancer Biology
- Chromium effects and bioremediation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Inflammatory Biomarkers in Disease Prognosis
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Heavy Metal Exposure and Toxicity
- Liver Disease Diagnosis and Treatment
- Tannin, Tannase and Anticancer Activities
- Cancer, Stress, Anesthesia, and Immune Response
- Medicinal Plants and Neuroprotection
- COVID-19 Clinical Research Studies
- Blood Pressure and Hypertension Studies
- Colorectal Cancer Surgical Treatments
- Paraoxonase enzyme and polymorphisms
- Dementia and Cognitive Impairment Research
- Chronic Kidney Disease and Diabetes
National Institutes for Food and Drug Control
2025
Tufts University
2023
Zhongshan Hospital
2022
Fudan University
2022
Sun Yat-sen University
2022
The First Affiliated Hospital, Sun Yat-sen University
2022
Capital Medical University
2020-2021
Peking University
2008-2021
Capital University
2020
Kunming Medical University
2019
Abstract Background Cross-sectional studies have reported that insulin resistance (IR) is associated with arterial stiffness. However, the relationship between IR and stiffness progression remains unclear. This study aims to evaluate association of triglyceride glucose (TyG) index high-density lipoprotein cholesterol (TG/HDL-C) ratio in a non-normotensive population. Methods A total 1895 prehypertensive (systolic pressure 120–139 mmHg or diastolic 80–90 mmHg) hypertensive ≥ 140 90 using...
The present study explored the role of gut microbiota and gut-associated metabolism in oral toxicity induced by TiO<sub>2</sub> NPs.
Due to its excellent physicochemical properties and wide applications in consumer goods, titanium dioxide nanoparticles (TiO2 NPs) have been increasingly exposed the environment public. However, health effects of oral exposure TiO2 NPs are still controversial. This study aimed illustrate hepatotoxicity induced by underlying mechanisms. Rats were administered with (29 nm) orally at doses 0, 2, 10, 50 mg/kg daily for 90 days. Changes gut microbiota hepatic metabolomics analyzed explore role...
The current pandemic of coronavirus disease 2019 (COVID-19) has affected >160 million individuals to date, and caused millions deaths worldwide, at least in part due the unclarified pathophysiology this disease. Identifying underlying molecular mechanisms COVID-19 is critical overcome pandemic. Metabolites mirror progression an individual can provide extensive insights into their pathophysiological significance each stage We a comprehensive view metabolic characterisation sera from...
The present study investigated the effect of oral exposure to TiO<sub>2</sub> NPs on lipid metabolism by serum lipidomics.
Existing literature pointed out that the liver may be target organ of toxicity induced by titanium dioxide nanoparticles (TiO2 NPs) via oral exposure. Gender differences in health effects widely exist and relevant toxicological research is important for safety assessment. To explore gender susceptibility TiO2 NP-induced hepatic underlying mechanism, we examined female male Sprague-Dawley rats administrated with NPs orally at doses 0, 2, 10 50 mg/kg body weight per day 90 days. The serum...
Objective: This study aimed to develop and validate a simple-to-use nomogram for early hepatocellular carcinoma (HCC) patients undergoing preoperative consultation doctors conducting postoperative evaluation. Methods: A total of 2, 225 HCC confirmed with stage I or II were selected from the Surveillance, Epidemiology, End Results database between January 2010 December 2015. The randomly divided into two groups: training group (N=1557) validation (N=668). Univariate multivariate hazards...
Background Myeloperoxidase (MPO) has been demonstrated to be a local mediator of inflammation in tissue damage various inflammatory diseases. Given its controversial effect on colorectal cancer (CRC), there growing interest investigating the role this enzyme CRC. The mechanism underlying MPO activity and CRC progression requires further clarification. Methods expression function were evaluated using TCGA analysis. TCGA, TIMER, Human Cell Landscape analyses used analyze correlation between...
Animal-derived foods are essential sources of vitamin D and 25-hydroxyvitamin in the human diet. Currently, relevant regulatory methods China limited to using non-derivatization determine content. In this study, 4-phenyl-1,2,4-triazoline-3-5-dione (PTAD) was used as a derivative reagent, ionization efficiencies were improved by introducing readily ionizable groups via Diels-Alder reaction. This method allowed for simultaneous determination animal-derived derivatization ultra performance...
BACKGROUND:Laparoscopic cholecystectomy (LC) is regarded as the criterion standard for gallstone therapy, but post-cholecystectomy syndrome (PCS) a common complication. This study aimed to analyze and identify differences in gut microbiome PCS patients. MATERIAL AND METHODS:This involved 8 patients (RS1), asymptomatic (RS2), healthy individuals (RS3). Genomic DNA of was extracted amplified with CTAB method. PCR products were sequenced Illumina High-Through Sequencing. Sequencing data...
Abstract Background To evaluate the association of physical activity (PA) intensity with cognitive performance at baseline and during follow-up. Methods A total 4039 participants aged 45 years or above from China Health Retirement Longitudinal Study were enrolled in visit 1 (2011–2012) followed for function 2 (2013–2014), 3 (2015–2016), 4 (2017–2018). We analyzed PA global cognition, episodic memory, mental intactness using adjusted regression methods evaluated long-term effect multiple...
Uncertainty remains regarding the association between resting heart rate (RHR) with hypertension and stroke because of limited inconsistent data. We assessed RHR, hypertension, stroke. In this cross‐sectional study, 14 677 participants from China Hypertension Survey study were analyzed. The history was conducted by questionnaires. RHR measured standardized electronic monitors. Multivariate logistic regression analyses performed to evaluate Moreover, a generalized additive model (GAM) smooth...
The relationship of immunoglobulin G (IgG) glycosylation with diabetes and diabetic nephropathy has been reported, but its role in retinopathy (DR) remains unclear. We aimed to investigate validate the association IgG DR.We analyzed N-linked profile primarily selected candidate glycans by lasso (least absolute shrinkage selection operator) regression analysis discovery population. findings were validated replication population using a binary logistics model. between significant panel...
Background The correlation between high white blood cell (WBC) count and poor prognosis has been identified in various types of cancer; however, the clinical significance immune context WBC colorectal cancer remains unclear. Methods Between February 2009 November 2014, 7,433 patients at Shanghai Cancer Center who had undergone elective surgery for were enrolled this retrospective cohort study. Patients divided into two groups: low preoperative groups. Propensity score matching was used to...
Metabolomics data analysis depends on the utilization of bioinformatics tools. To meet evolving needs metabolomics research, several integrated platforms have been developed. Our group has developed a desktop platform IP4M (integrated Platform for Data Analysis) which allows users to perform nearly complete in one-stop. With extensive usage IP4M, more and demands were raised from worldwide web version customized workflow. Thus, iMAP Analysis Platform) was with extended functions, improved...
Abstract Titanium dioxide nanoparticles (TiO 2 NPs) have already been used as food additive in various products and are usually consumed with a considerable amount of sugar. Oral consumption TiO NPs poses concerning health risks; however, research on the combined effect ingested glucose is limited. We examined young Sprague‐Dawley rats administrated orally at doses 0, 2, 10 50 mg/kg body weight per day without 1.8 g/kg for 30 90 days. Heart rate, systolic diastolic blood pressure,...
Colorectal cancer (CRC) is one of the most fatal cancers digestive system. Although stem cells and metabolic reprogramming have an important effect on tumor progression drug resistance, their combined CRC prognosis remains unclear. Therefore, we generated a 21-gene mRNA stemness index-related risk score model, which was examined in The Cancer Genome Atlas Gene Expression Omnibus databases (1323 patients) validated using Zhongshan Hospital cohort (200 patients). high-risk group showed more...
Abstract Introduction Adoptive cellular therapy with tumor‐infiltrating lymphocytes (TIL) has demonstrated promising clinical benefits in several solid tumors, but the efficacy of this might be compromised by “prone‐to‐exhaustion” phenotype TIL and poor persistence vivo. This calls for a robust expansion process to produce large number cells usage while at same time maintaining favorable anti‐tumor function memory phenotype. Previous studies showed that PI3K‐AKT signaling pathway plays key...
Background Perioperative anemia and transfusion are intertwined with each other, both have adverse impacts on the survival of colorectal cancer (CRC) patients. But treatment still relies in several countries, which leads us to question effects tolerance long-term outcomes CRC We investigated combined effect preoperative postoperative blood transfusion, imposes a greater risk survival, compare overall (OS) disease-free (DFS) patients undergoing surgery. Methods A retrospective...
Drug repositioning allows expedited discovery of new applications for existing compounds, but re-screening vast compound libraries is often prohibitively expensive. “Connectivity mapping” a process that links drugs to diseases by identifying compounds whose impact on expression in collection cells reverses the disease’s disease-relevant tissues. The LINCS project has expanded universe and which data are available, even with this effort, many clinically useful combinations missing. To...
This study aimed to investigate the association of IgG glycosylation and esophageal precancerosis for squamous cell carcinoma determine its role in inflammation. Primary glycans selected by least absolute shrinkage selection operator (LASSO) algorithm were validated using univariate multivariate logistics models plus restricted cubic spline functions. In total, 24 direct 27 derived traits detected, among which four three primarily selected. Then, GP5 (adjusted OR: 0.805), GP17 1.305), G12n...