A5102941715- HIV Research and Treatment
- Herpesvirus Infections and Treatments
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Enhanced Recovery After Surgery
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Tendon Structure and Treatment
- RNA modifications and cancer
- Foot and Ankle Surgery
- Medical Research and Treatments
- Cancer-related Molecular Pathways
- Immune cells in cancer
- Autophagy in Disease and Therapy
- Biomarkers in Disease Mechanisms
- Advanced Sensor and Energy Harvesting Materials
- Cancer survivorship and care
- Acupuncture Treatment Research Studies
- Lung Cancer Treatments and Mutations
- Inflammatory Biomarkers in Disease Prognosis
- Central Venous Catheters and Hemodialysis
- Biochemical and biochemical processes
- Cognitive and developmental aspects of mathematical skills
- Acne and Rosacea Treatments and Effects
- interferon and immune responses
- Zebrafish Biomedical Research Applications
Shanghai Ninth People's Hospital
2020-2025
Shanghai Jiao Tong University
2020-2025
Beijing Technology and Business University
2023-2024
Xuzhou Medical College
2023
Shaanxi University of Technology
2023
Southeast University
2023
Nanjing Drum Tower Hospital
2013-2023
National Medical Products Administration
2023
State Key Laboratory of Plant Genomics
2023
National Vaccine and Serum Institute
2023
Abstract Background: Growing evidence suggests that long non-coding RNAs (lncRNAs) exert pivotal roles in fostering chemoresistance across diverse tumors. Nevertheless, the precise involvement of lncRNAs modulating within context gallbladder cancer (GBC) remains obscure. This study aimed to uncover how regulate cancer, offering potential targets overcome drug resistance. Methods: To elucidate relationship between gemcitabine sensitivity and small nucleolar RNA host gene 1 ( SNHG1 )...
Abstract With the spread of infectious diseases around world, health monitoring is gaining importance as a key technology for disease prevention. Contact inevitably causes potential transmission between patient and physician. Hence, research on contactless patients medical workers leads to increased attention. Current systems provide various wireless solutions, but two dilemmas need be solved urgently. The first replacing rigid substrate with an all‐flexible structure. second ability...
Background The correlation between high white blood cell (WBC) count and poor prognosis has been identified in various types of cancer; however, the clinical significance immune context WBC colorectal cancer remains unclear. Methods Between February 2009 November 2014, 7,433 patients at Shanghai Cancer Center who had undergone elective surgery for were enrolled this retrospective cohort study. Patients divided into two groups: low preoperative groups. Propensity score matching was used to...
Abstract Microglia are the primary immune cells in central nervous system, which plays a vital role neuron development and neurodegenerative diseases. Microglial precursors peripheral hematopoietic tissues colonize system during early embryogenesis. However, how intrinsic extrinsic signals integrate to regulate microglia’s differentiation remains undefined. In this study, we identified cerebral white matter hyperintensities susceptibility gene, programmed cell death protein 11 ( PDCD11 ), as...
Oncolytic herpes simplex virus (oHSV) is a type of that selectively targets and kills cancer cells, leaving normal cells unharmed. Accurate viral titer great importance for the production application oHSV products. Droplet digital PCR (ddPCR) known having good reproducibility, not requiring standard curve, being affected by inhibitors, precise even in detection low copies. In present study, we developed droplet assay quantification HSV-1 applied it production. The established ddPCR showed...
The innate immune restriction factor SAMHD1 can inhibit diverse viruses in myeloid cells. Mechanistically, inhibits lentiviral replication including HIV-1 by depleting the nucleotide pool to interfere with their reverse transcription. Equine infectious anemia virus (EIAV) is an ancient lentivirus that preferentially attacks macrophages. However, mechanism which EIAV successfully establishes infection macrophages functional remains unclear. Here, we demonstrate while equine SAMDH1 limit at...
Colorectal cancer (CRC) is one of the most fatal cancers digestive system. Although stem cells and metabolic reprogramming have an important effect on tumor progression drug resistance, their combined CRC prognosis remains unclear. Therefore, we generated a 21-gene mRNA stemness index-related risk score model, which was examined in The Cancer Genome Atlas Gene Expression Omnibus databases (1323 patients) validated using Zhongshan Hospital cohort (200 patients). high-risk group showed more...
Abstract Background: Lumbar disc herniation (LDH) is a clinically common degenerative spinal disease that adversely affects patients’ quality of life and work ability. Although several articles have reported acupotomy can improve the clinical symptoms LDH, efficiency has not been scientifically or methodically evaluated. The primary objective this study to evaluate synthesize evidence on effectiveness safety therapy in patients with LDH. Method: We plan search eight English Chinese...
Background Tai Chi Chuan (TCC) is a physical activity modality that originated in China and now widely popular around the world. Although there are series of articles reporting TCC can improve balance other functional symptoms variety populations, including elderly, patients with stroke, Parkinson's disease, its efficiency has not been scientifically methodically evaluated subjects ankle instability (FAI). Moreover, no literature directly comparing conventional training (CBT) interventions...
Background. BRAF exon 15 p.V600E (BRAF V600E) mutation has been established as an important molecular marker for papillary thyroid carcinoma diagnosis by ultrasound-guided fine-needle aspiration biopsy (FNAB). Sanger sequencing is the gold standard detecting V600E mutations but fails to identify low-frequency mutations. However, droplet digital PCR (ddPCR) a popular new method Here, we compare efficiency of and detection in (FNA) samples. Methods. Thyroid samples from 278 patients with 310...
Abstract The pathogenesis of thyroid dysgenesis (TD) is not well understood. Here, using a combination single-cell RNA and spatial transcriptome sequencing, we identify subgroup NF-κB-activated thyrocytes located at the center tissues in postnatal mice, which maintained partially mesenchymal phenotype. These cells actively protruded out primordium generated new follicles zebrafish embryos through continuous tracing. Suppressing NF-κB signaling affected thyrocyte migration follicle formation,...
Abstract Objective: To provide evidence for selecting an appropriate peripherally inserted central catheter (PICC) insertion technique by comparing the success rate and incidence of complications with 3 PICC techniques. Methods: We assigned enrolled patients to groups according selected individual patient: Group A, usual (traditional, blind insertion); B, Modified Seldinger Technique (MST) without ultrasound guidance; group C, ultrasound-guided MST insertion. compared among these groups....
Tetherin is an interferon-inducible host cell factor that blocks the viral particle release of enveloped viruses. Most knowledge regarding interaction between tetherin and viruses has been obtained using primate lentiviral system. However, much less known about functional roles on other lentiviruses. Equine infectious anemia virus (EIAV) important macrophage-tropic lentivirus widely used as a practical model for investigating evolution host-virus relationship. The range EIAV reported to...
Propionibacterium acnes causes upregulation of inflammatory factors, such as cycloxygenase-2, prostaglandin E2, interleukin-1β, and tumor necrosis factor-alpha, increased levels reactive oxygen species (ROS) inward flow calcium ions. This the antimicrobial peptide LL-37 inflammation skin, leading to redness, swelling, itching other symptoms. Schisandra chinensis fruit oil (SCO) is rich in lignan active ingredients with various antioxidant anti-inflammatory properties.In this study, SCO...
Abstract Background We have developed a tridirectional regimen combining intraperitoneal, intravenous, and oral chemotherapy as treatment for patients with advanced gastric cancer individualized these chemotherapeutics according to mRNA expression. This multicenter Phase III umbrella study compared the efficacy safety of intraperitoneal systemic that standard chemotherapy. Methods BRCA1/TOPO1 expression was examined in all enrolled patients. The were then randomized ratio 3:1 an arm control...
To study the clinical features and prognosis of children their family members with clusters severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant infection under admission mode parent-child ward.A retrospective analysis was performed on medical data 190 SARS-CoV-2 who were admitted to Shanghai Sixth People's Hospital, designated hospital for disease 2019 (COVID-19), April 8 May 10, 2022.Both child adult groups mainly mild COVID-19, proportion cases in group higher than...