A5012755658- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Nanoplatforms for cancer theranostics
- Glioma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced Neuroimaging Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Renal cell carcinoma treatment
- Photodynamic Therapy Research Studies
- RNA modifications and cancer
- Congenital heart defects research
- MicroRNA in disease regulation
- Medical Imaging Techniques and Applications
- Thyroid Disorders and Treatments
- Advanced X-ray and CT Imaging
- Liver Disease Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Gene expression and cancer classification
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Renal and related cancers
- Multiple Sclerosis Research Studies
- Zebrafish Biomedical Research Applications
South China University of Technology
2019-2025
Guangzhou Medical University
2016-2025
Guangzhou First People's Hospital
2016-2025
Xiangya Hospital Central South University
2024
Central South University
2024
Shanghai Jiao Tong University
2015-2024
Shanghai Ninth People's Hospital
2018-2024
Tianjin Medical University
2023-2024
City Of Hope National Medical Center
2024
City of Hope
2023-2024
To characterize and compare the initial clinical imaging features of coronavirus disease 2019 (COVID-19) in pediatric adult patients undergoing chest CT.A total 61 patients, consisting 47 adults (aged 18 years or older) 14 younger than years) with laboratory-confirmed COVID-19 confirmed by real-time reverse-transcription polymerase chain reaction between January 25 February 15, 2020, were enrolled this study. All underwent CT within 3 days after reverse transcription test. The presentation,...
MicroRNAs (miRNAs) can act as oncogenes or tumor suppressors by controlling cell proliferation, differentiation, metastasis and apoptosis, miRNA dysregulation is involved in the development of pancreatic cancer (PC). Our previous study demonstrated that Gabra3 plays critical roles progression. However, whether regulated miRNAs PC remains unknown. The expression levels miR-92b-3p were measured quantitative PCR (qPCR), immunoblotting, situ hybridization (ISH) immunohistochemistry (IHC)....
Abstract: Theranostic nanoparticles with both imaging and therapeutic abilities are highly promising in successful diagnosis treatment of the most devastating cancers. In this study, dual-modal photothermal effect hyaluronan (HA)-modified superparamagnetic iron oxide (HA-SPIONs), which was developed a previous were investigated for CD44 HA receptor-overexpressing breast cancer vitro vivo experiments. Heat is found to be rapidly generated by near-infrared laser range irradiation HA-SPIONs....
BackgroundPancreatic cancer (PC) is one of the most lethal solid malignancies in world due to its excessive cell proliferation and aggressive metastatic features. Emerging evidences revealed importance posttranscriptional modifications RNAs PC progression. However, knowledge about 5-methylcytosine (m5C) RNA modification still extremely limited. In this study, we attempted explore expression changes clinical significances 12 known m5C-related genes among patients.MethodsA total 362 normal 382...
The codelivery of drugs at specific optimal ratios to cancer cells is vital for combination chemotherapy. However, most the current strategies are unable coordinate loading and release drug combinations acquire precise controllable synergistic ratios. In this work, we designed an innovative dual-drug backboned reduction-sensitive polyprodrug PEG-P(MTO-ss-CUR) containing anticancer mitoxantrone (MTO) curcumin (CUR) ratio reverse resistance. Due synchronous activation polymer backbone...
The normoxic and hypoxic microenvironments in solid tumors cause cancer cells to show different sensitivities various treatments. Therefore, it is essential develop therapeutic modalities based on the tumor microenvironment. In this study, we designed size-switchable nanoparticles with self-destruction penetration characteristics for site-specific phototherapy of cancer. This was achieved by photodynamic therapy perivascular microenvironment due high local oxygen concentrations photothermal...
Pancreatic ductal adenocarcinoma (PDAC) with cystic features presents significant challenges in achieving an accurate preoperative diagnosis and implementing appropriate clinical management. The aim of this study was to analyze the dynamic contrast-enhanced computed tomography (DCE-CT) findings PDACs lesions correlate them histopathological findings. We retrospectively reviewed 40 patients pathology-proven exhibiting who underwent DCE-CT imaging. CT manifestations were classified into three...
The highly malignant feature and difficulties for early diagnosis are the key reasons contributing to poor prognosis of pancreatic cancer (PC) patients. NFE2L3 is a nuclear transcription factor, which has been reported an important biomarker several tumors. But role in PC remained undefined. Herein, through qPCR immunohistochemistry, we found significantly increased tissues as compared with adjacent non-tumor tissues. While reducing expression suppressed invasion abilities cells, elevated...
Methylation of the O 6 -methylguanine methyltransferase (MGMT) gene promoter is correlated with effectiveness current standard care in glioblastoma patients. In this study, a deep learning pipeline designed for automatic prediction MGMT status 87 patients contrast-enhanced T1W images and 66 fluid-attenuated inversion recovery(FLAIR) images. The end-to-end completes both tumor segmentation classification. better performance comes from FLAIR (Dice score, <mml:math...
Low immune infiltration severely hinders the efficacy of cancer immunotherapy. Here, we developed a manganese-phenolic network platform (TMPD) to boost antitumor immunity via stimulator interferon gene (STING)-amplified activation cascade. TMPD is based on doxorubicin (DOX)-loaded PEG-PLGA nanoparticles and further coated with manganese (Mn2+)-tannic acid (TA) networks. Mechanistically, DOX-based chemotherapy Mn2+-mediated chemodynamic therapy effectively promoted immunogenic cell death...
Background: Congenital hypothyroidism (CH) is the most common neonatal metabolic disorder. In patients with CH in China, thyroid dyshormonogenesis more than dysgenesis; however, genetic causes of due to remain largely unknown. Therefore, we aimed identify novel candidate causative genes for CH. Methods: To genes, a total 599 were enrolled and next-generation sequencing was performed. The functions identified variants confirmed using HEK293T FTC-133 cell lines vitro mouse model organism vivo....
The highly refractory nature of pancreatic cancer (PC) to chemotherapeutic drugs is one the key reasons contributing poor prognosis this disease. MicroRNAs (miRNAs) are regulators gene expression and have been implicated in a variety processes from development through drug resistance. Herein, miRNA profiling gemcitabine-resistant (GR) parental PANC-1 cell lines, we found consistent reduction miR-3656 GR cells. overexpression enhanced antitumor effect gemcitabine, whereas silencing resulted...
Developing novel activatable photosensitizers with excellent plasma membrane targeting ability is urgently needed for smart photodynamic therapy (PDT). Herein, a tumor acidity-activatable photosensitizer combined two-step bioorthogonal pretargeting strategy to anchor on the effective PDT developed. Briefly, artificial receptors are first anchored cell using cell-labeling agents (Az-NPs) via enhanced permeability and retention effect achieve labeling. Then, pH-sensitive nanoparticles (S-NPs)...
Abstract Purpose To explore a subregion-based RadioFusionOmics (RFO) model for discrimination between adult-type grade 4 astrocytoma and glioblastoma according to the 2021 WHO CNS5 classification. Methods 329 patients (40 astrocytomas 289 glioblastomas) with histologic diagnosis was retrospectively collected from our local institution The Cancer Imaging Archive (TCIA). volumes of interests (VOIs) were obtained four multiparametric MRI sequences (T 1 WI, T WI + C, 2 -FLAIR) using (1) manual...
To determine if heroin body packing has occurred using computed tomography (CT), and to evaluate the role of CT in screening such cases.We collected 158 cases suspected drug packers' imaging materials (all underwent CT, 42 were imaged plain x-ray film) from September 5, 2005 April 23, 2008. Abdominal-pelvic appearances (shape, size, number, location density) abdominal film manifestations retrospectively observed for those who finally confirmed as packers through passing evacuated...