A5003951722- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Nanoparticle-Based Drug Delivery
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Virus-based gene therapy research
- Click Chemistry and Applications
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Inflammation biomarkers and pathways
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- Cardiac, Anesthesia and Surgical Outcomes
- MicroRNA in disease regulation
- Neonatal and Maternal Infections
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Advanced Fluorescence Microscopy Techniques
- Polymer Surface Interaction Studies
- Supramolecular Self-Assembly in Materials
- Collagen: Extraction and Characterization
- Nanowire Synthesis and Applications
- Radio Wave Propagation Studies
- Graphene and Nanomaterials Applications
- Sulfur Compounds in Biology
Xi'an Jiaotong University
2025
Second Affiliated Hospital of Zhejiang University
2025
Shenyang Pharmaceutical University
2024
Affiliated Hospital of Nantong University
2020-2024
Nantong University
2020-2024
South China University of Technology
2018-2023
Guangzhou First People's Hospital
2020-2021
Guangzhou Medical University
2020-2021
Wuhan University
2014
Abstract Prodrugs activated by endogenous stimuli face the problem of tumor heterogeneity. Bioorthogonal prodrug activation that utilizes an exogenous click reaction has potential to solve this problem, but most strategies currently used rely on presence receptors or overexpressed enzymes. We herein integrate acidic, extracellular microenvironment a and as general strategy for activation. This was achieved using pH‐responsive polymer containing tetrazine groups, which formed unreactive...
Adoptive cellular therapy utilizing chimeric antigen receptor redirected T (CAR-T) cells has shown impressive therapeutic effects on hematological malignancies. In contrast, the efficacy of CAR-T therapies in treating solid tumors is still poor, which largely due to inefficient penetration into and immunosuppressive tumor microenvironment. Herein, we engineered hyaluronidase (HAase) checkpoint blocking antibody α-PDL1 cell surface via highly efficient biocompatible bioorthogonal click...
Glioblastoma (GBM) is a highly invasive tumor with poorly defined boundaries, often leaving residual tissue after surgery, which contributes to the recurrence and poor prognosis. A critical challenge in GBM treatment precise identification of boundaries during surgery achieve safe complete resection. In this study, we present novel near-infrared fluorescent agent, IR-PEG-cRGD, that designed accurately delineate for surgical navigation IR-PEG-cRGD successfully prepared from cyanine dye...
Thyroid cancer treatments often impact patients' quality of life (QOL). The transoral endoscopic thyroidectomy vestibular approach (TOETVA) gets lot attention as a scarless alternative, but its influence on postoperative QOL remains unclear. This study compares TOETVA and open surgery outcomes regarding QOL, scar satisfaction, mental health in thyroid patients to inform surgical decision-making. We retrospectively analyzed 221 treated between January 2017 September 2024: 136 underwent...
Abstract Prodrugs activated by endogenous stimuli face the problem of tumor heterogeneity. Bioorthogonal prodrug activation that utilizes an exogenous click reaction has potential to solve this problem, but most strategies currently used rely on presence receptors or overexpressed enzymes. We herein integrate acidic, extracellular microenvironment a and as general strategy for activation. This was achieved using pH‐responsive polymer containing tetrazine groups, which formed unreactive...
Developing novel activatable photosensitizers with excellent plasma membrane targeting ability is urgently needed for smart photodynamic therapy (PDT). Herein, a tumor acidity-activatable photosensitizer combined two-step bioorthogonal pretargeting strategy to anchor on the effective PDT developed. Briefly, artificial receptors are first anchored cell using cell-labeling agents (Az-NPs) via enhanced permeability and retention effect achieve labeling. Then, pH-sensitive nanoparticles (S-NPs)...
This study aimed to explore the impact of hypoxic hepatitis (HH) on survival in heart failure (HF) patients and develop an effective machine learning model predict 30-day mortality risk HF with HH.In Medical Information Mart for Intensive Care (MIMIC)-III IV databases, clinical data situations admitted intensive care unit (ICU) were retrospectively collected. Propensity Score Matching (PSM) analysis was used balance baseline differences between without HH. Kaplan Meier multivariate Cox...
Activatable dual-modal molecular imaging probes present a promising tool for the diagnosis of malignant tumors. However, synchronously enhancing signals under single stimulus is challenging. Herein, we propose an activatable bimodal probe that integrates aggregation-induced emission luminogens (AIEgens) and iron oxide nanoparticles (IOs) to synergistically enhance near-infrared fluorescence (NIRF) intensity magnetic resonance (MR) contrast through tumor acidity-mediated click reaction. Tumor...
The aims of this study were to prepare the collagen-poly (3-acrylamidophenylboronic acid) nanoparticles (collagen-PAPBA NPs) encapsulating doxorubicin (DOX) and research their anticancer efficacy in ovarian cancer.Collagen-PAPBA NPs prepared, morphology stability observed by transmission electron microscopy (TEM) dynamic light scattering system (DLS). Preparation doxorubicin-loaded Collagen-PAPBA (DOX-loaded then drug-loading content, encapsulation efficiency, vitro drug-release profiles...
Abstract Background Gram-negative bacterial lipopolysaccharide (LPS) is a major component of inflammation and plays key role in the pathogenesis sepsis. According to our previous study, expression lipoprotein-associated phospholipase A2 (Lp-PLA2) significantly upregulated septic patients positively correlated with severity this disease. Herein, we investigated potential roles Lp-PLA2-targeting microRNAs (miRNAs) LPS-induced murine mononuclear macrophages (RAW264.7 cells). Methods In...
An accurate assessment of the severity and prognosis sepsis, especially septic shock, is vital for tailored treatment this condition. miRNA participates in inflammatory response cell apoptosis regulates inflammation-related signaling pathways. Immune disorders often accompany sepsis. Since serum expression superior to traditional biological markers terms sensitivity specificity, its role sepsis has increasingly been recognized.Serum miRNAs were extracted from patients healthy individuals by...
In the pathogenic yeast Candida albicans, DNA damage response contributes to pathogenicity by regulating cell morphology transitions and maintaining survival in induced reactive oxygen species (ROS) host cells. However, function of nucleotide excision repair (NER) C. albicans has not been extensively investigated. To better understand its role virulence, we studied Rad23 protein detail. The RAD23 deletion strain overexpression both exhibit UV sensitivity, confirming critical pathway. Genetic...
Background: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia encountered in clinical practice, and it associated with an increased risk of mortality, stroke, peripheral embolism. The stroke AF heterogeneous dependent on underlying conditions included current stratification schemes. Recently, CHA2DS2-VASc score has been incorporated into guidelines to encompass common factors observed routine practice. aim this study was predictive value prognosis patients determine...
Background: The purpose of this study was to investigate the tolerance and safety carbohydrate administration patients with multiple injuries prior surgery, analyze effects intake on their immediate insulin resistance (IR), postoperative complications, length hospital stay.