A5101797824- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Photochemistry and Electron Transfer Studies
- DNA and Nucleic Acid Chemistry
- Biosensors and Analytical Detection
- RNA Interference and Gene Delivery
- Analytical Chemistry and Sensors
- Bioactive Compounds and Antitumor Agents
- Alzheimer's disease research and treatments
- Supercapacitor Materials and Fabrication
- Computational Drug Discovery Methods
- Porphyrin and Phthalocyanine Chemistry
- Analytical chemistry methods development
- Electrochemical sensors and biosensors
- Synthesis and biological activity
- Conducting polymers and applications
- Microbial Natural Products and Biosynthesis
- Sulfur Compounds in Biology
- Nanowire Synthesis and Applications
- Graphene and Nanomaterials Applications
- Gas Sensing Nanomaterials and Sensors
- Photodynamic Therapy Research Studies
- Advanced Biosensing Techniques and Applications
- Traditional and Medicinal Uses of Annonaceae
Nanjing Agricultural University
2016-2025
Shandong University
2022
University of Wisconsin–Milwaukee
2018-2020
Wuhan Institute of Physics and Mathematics
2020
College of Medical Sciences
2018
Beijing National Laboratory for Molecular Sciences
2013-2017
Chinese Academy of Sciences
2013-2017
University of Chinese Academy of Sciences
2013-2016
Northwestern Polytechnical University
2016
Shanghai Institute of Microsystem and Information Technology
2013-2014
This work not only rules out the possibility of mutual transformation among BI3HC-A, BI3HC-B, and BI3HC-C forms in S 1 state but also proposes a solvent-polarity-regulated ESIPT behavior for BI3HC-A fluorophores.
Crops will be harmed by fungi, pests and weeds during their growth. In the past half century, scientists have conducted in-depth research on natural products extracted from microorganisms, plants or animals, used derivatives as lead for pesticides discovery. Natural product advantages of easy degradation in environment, selective control safety to non-target organisms. This review summarizes studies recent years, including chemical modification biosynthesis, mainly fungicides, herbicides,...
Putative G-quadruplex-forming sequences (PQS) are highly prevalent in human genome; however, the structures and functions of most PQSs genome poorly understood. Therefore, selective recognition certain types G-quadruplexes (G4s) is important for study G4s. A new light up fluorescent probe, BPBC composed benzimidazole carbazole moieties was designed synthesized. possesses a crescent-shaped π-conjugated planar core that slightly larger than dimension G-quartet plane This structure endows with...
DNA sequences that can form G-quadruplexes (G4s) are highly prevalent in the genome. However, structures and functions of most G4-forming genome poorly understood. Therefore, development molecular probes for G4 recognition biological samples, especially with long wavelength, important basic research G4s. Squaraines dyes exhibit sharp intense absorption strong emission red to NIR region, but very few them have been reported as nucleic acids. Here we report interactions two squaraine dyes, STS...
A new fluorophore based on guanidine substituted 1,8-naphthalimide was synthesized and characterized. In aqueous solution, the group undergoes deprotonation/protonation with a pKa of ∼8.5 in ground-state ∼0.9 excited-state. The emission its protonated deprotonated forms exhibits large Stokes shift (Ex/Em: 350/460 nm 400/580 nm) due to excited-state intramolecular charge transfer (ICT) process. form this dual fluorescence (Em: 460 580 nm; Ex: 350 that is contributed by an deprotonation...
LeuRS and PPO are important targets in the development of green pesticides; novel diphenyl-(thio)ether-containing benzoxaborole derivatives were designed synthesized as dual-target enzyme inhibitors; their antifungal activities against six kinds common plant pathogens vitro herbicidal purslane barnyard grass studied. Most target compounds showed excellent activity pathogenic fungi vitro, this is highlighted by 6c 6h, both displayed 100.0% inhibition effects three tested under concentrations...
The lack of ideal photosensitizers limits the clinical application photodynamic therapy (PDT). Here we report PDT efficiency dicyanomethylene substituted benzothiazole squaraine derivatives. This class derivatives possess strong absorption and long excitation emission wavelengths (ex/em, 685/720 nm). They show negligible dark toxicity, but can generate singlet oxygen under irradiation resulting in apoptosis necrosis cells (phototoxicity). Changing side chains these compounds greatly...
Herbal tea is widely consumed in Jianghua, a Yao autonomous county Hunan Province, China, to prevent and treat diseases. The materials herbal at the traditional medicinal markets Dragon Boat Festival remain unknown. aims of paper were (1) specifically investigate used by nationalities (2) record most common culturally important plant species markets, (3) compare medical tradition both for between Jianghua Lingnan regions. During 2016–2017, 215 vendors interviewed plants document knowledge...
Recent outbreaks of Ebola-virus infections in several countries demand a rapid point-of-care (POC)-detection strategy. This paper reports on an innovative pathway founded electronic-resonance-frequency modulation to detect Ebola glycoprotein (GP), the basis carrier-injection–trapping–release–transfer mechanism and standard antibody–antigen-interaction principle within dielectric-gated reduced graphene oxide (rGO) field-effect transistor (GFET). The sensitivity detection can be significantly...
The G-quadruplex (G4) structures of nucleic acids are considered to play an intrinsic role in gene expression. To this end, the development new G4 ligands has attracted extensive research interests towards potential applications as G4-targeted drugs and molecular probes. date, majority have been composed extended planar aromatic scaffold that interacts with terminal G-tetrad plane via π-π interactions, various side chains interact sugar-phosphate backbone, loops or grooves structures. act...
Based on the structures of natural products streptochlorin and pimprinine derived from marine or soil microorganisms, a series derivatives containing nitrile group were designed synthesized through acylation oxidative annulation. Evaluation for antifungal activity showed that compound 3a could be regarded as most promising candidate—it demonstrated over 85% growth inhibition against Botrytis cinerea, Gibberella zeae, Colletotrichum lagenarium, well broad spectrum in primary screening at...
The development of fluorescent probes to selectively and sensitively detect more than one target analyte under a given condition is challenging task due the lack designing strategies. In this paper, we report utilisation solvatochromic properties coumarin-pyridine based probe L1 Mg2+ PPi, respectively, by using different solvents such as acetonitrile, DMF DMF-HEPES buffered solutions. When acetonitrile was used solvent, weakly showed selective sensitive fluorescence "turn on" response...
A real-time FET sensor was demonstrated for detecting aqueous phosphate ions through molecular engineering of surface passivation and selective probes.
A highly sensitive and novel colorimetric rolling circle amplification (RCA) immunoassay for detecting C-reactive protein (CRP) has been developed. In the assay, a CRP capture antibody was immobilized on magnetic beads detection conjugated with single-stranded DNA (ssDNA) using N-[ε-maleimidocaproyloxy] sulfosuccinimide ester. Along addition of CRP, "sandwich" structure formed. Subsequently, ssDNA used as primer to initiate RCA reaction in presence circular template, phi29 polymerase...
Fumonisin B1 (FB1) is a toxin produced by the metabolism of Fusarium oxysporum, which can cause serious effects on nervous, respiratory, digestive, and reproductive systems humans or animals; it known as one highly toxic epidemic contaminants. Herein, we report visual inspection FB1 using bipolar electrodes (BPEs) with an array-based electrochemiluminescence (ECL) platform. The sensor consists PDMS cover glass substrate containing array 10 ITO electrodes. A specific sensing interface was...