A5072453184- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Total Knee Arthroplasty Outcomes
- Visual perception and processing mechanisms
- Ovarian cancer diagnosis and treatment
- Neural dynamics and brain function
- Endometrial and Cervical Cancer Treatments
- Estrogen and related hormone effects
- Orthopaedic implants and arthroplasty
- Endometriosis Research and Treatment
- Orthopedic Infections and Treatments
- Urologic and reproductive health conditions
- Bladder and Urothelial Cancer Treatments
- Wildlife Ecology and Conservation
- Knee injuries and reconstruction techniques
- Cervical Cancer and HPV Research
- Advanced Radiotherapy Techniques
- Uterine Myomas and Treatments
- Venous Thromboembolism Diagnosis and Management
- Radiation Therapy and Dosimetry
- Radiopharmaceutical Chemistry and Applications
- Effects of Radiation Exposure
- DNA Repair Mechanisms
- CCD and CMOS Imaging Sensors
- Shoulder Injury and Treatment
Jikei University School of Medicine
2015-2024
Chikushi Jogakuen University
2009-2024
Fukui University of Technology
2004-2022
Osaka Medical and Pharmaceutical University
2010-2020
Kobe Kaisei Hospital
2013-2019
Kyoto University
1989-2019
Jikei University Kashiwa hospital
2017-2018
Kobe University
2005-2017
Osaka University
2006-2008
Kyushu University
1991-2006
Abstract Objective Autophagy, an evolutionarily conserved process for the bulk degradation of cytoplasmic components, serves as a cell survival mechanism. The purpose this study was to elucidate role autophagy in human chondrocytes and pathophysiology osteoarthritis (OA). Methods Autophagy articular cartilage primary assessed using antibodies markers light chain 3 beclin 1. states under catabolic nutritional stresses were examined. We also examined effects inhibition or induction stimulation...
The mouse insulin-like growth factor 2 ( Igf2 ) locus is a complex genomic region that produces multiple transcripts from alternative promoters. Expression at this regulated by parental imprinting. However, despite the existence of putative imprinting control elements in upstream region, imprinted transcriptional repression abolished null mutations linked H19 locus. To clarify extent to which contains autonomous we have performed functional and comparative analyses human. Here report...
Abstract In this study, we examined the effects of overexpression SIRT1 on IL‐1β‐induced gene expression changes in human chondrocytes to explore a protective role chondrocytes. was overexpressed by plasmid under stimulation with IL‐1β. also inhibited siRNA Gene were real‐time PCR. The interaction and p65 (NF‐κB) Western blotting. SIRT1, MMP‐13, ADAMTS‐5 expressions cartilage immunohistochemistry. IL‐1β significantly up‐regulated MMP‐1 , 2 9 13 . Overexpression up‐regulation those genes...
G protein-coupled receptor 30 (GPR30) is a 7-transmembrane estrogen that functions alongside traditional receptors to regulate the cellular responses estrogen. Recent studies suggest GPR30 expression associated with poor prognosis, and this due GPR30-mediated transactivation of EGFR in breast cancer. However, biological contribution ovarian cancer remains unclear. The purpose study was elucidate relationships between clinicopathological findings, determine how signaling cascade influences...
It has been recently reported that human anterior cruciate ligament (ACL) ruptured tissue contains abundant vascular stem cells contribute to tendon-bone healing in an immunodeficient rat model of ACL reconstruction.Autologous effect on the maturation bone-tendon integration reconstruction.Controlled laboratory study.Twenty healthy adult beagle dogs underwent bilateral reconstruction using ipsilateral flexor digitorum superficialis tendon and were divided into 2 groups: right knee (a...
Abstract Background Ovarian cancer (OC) is a leading cause of cancer-related death in women, and thus an accurate diagnosis the predisposition its early detection necessary. The aims this study were to determine whether serum exosomal microRNA-34a (miR-34a) ovarian could be used as potential biomarker. Methods Exosomes from OC patients’ collected, miRNAs extracted. relative expression miR-34a was calculated 58 samples by quantitative real-time polymerase chain reaction. Results Serum levels...
Progression of endometriosis is considered estrogen-dependent. Dietary soy isoflavones may affect the risk endometriosis, and polymorphisms in estrogen receptor genes modify this association. We examined associations among isoflavone intake, 2 (ESR2) gene endometriosis.We recruited women age 20-45 years old who had consulted a university hospital for infertility Tokyo, Japan 1999 or 2000. A total 138 eligible were diagnosed laparoscopically classified into 3 subgroups: control (no...
Recently, cytology has been applied to the diagnosis of oral lesions. We aimed explore diagnostic accuracy based on histological diagnosis. Histological diagnoses 327 cases were classified as Negative, Borderline lesion –, +, intraepithelial neoplasia/carcinoma in situ (OIN/CIS), or Positive. Cytological NILM (negative for malignancy), LSIL (low-grade squamous lesion), HSIL (high-grade SCC (squamous cell carcinoma). The slides evaluated by 10 raters and results compared with histology...
The rate of lymph node metastasis is extremely low in patients with low-risk endometrial cancer; lymphadenectomy may be unnecessary for these under an accurate preoperative diagnosis. aim this study was to evaluate the diagnostic accuracy myometrial invasion (MI) on magnetic resonance imaging (MRI) and intraoperative frozen sections (FSs).Endometrial cancer diagnosed a total 378 by curettage, MRI, FSs; underwent hysterectomy. depth MI evaluated between FSs, final paraffin (PSs). histologic...
(Objectives) We herein assessed the influence of Epidermal Growth Factor Receptor (EGFR) gene mutations on EGFR expression levels, downstream mediators such as Akt or ERK, and overall survival in patients with ovarian cancer. Study Design) mutation status was analyzed by direct sequencing 102 Japanese cancer patients. The expression, phosphorylated (pAkt), ERK (pERK) were determined immunohistochemistry. (Results) Twenty-nine detected 24 patinets (23.5%). observed 27.9% (19/68) serous...
<b><i>Objective:</i></b> To evaluate the sensitivity and specificity of endometrial cytology obtained by intrauterine sample using a descriptive reporting format for cytological diagnosis. <b><i>Study Design:</i></b> 10,152 consecutive scrapings in 13 different Japanese hospitals were analyzed. Cytological results classified as ‘negative malignancy’, ‘atypical cells’ (ATEC), ‘endometrial hyperplasia’, hyperplasia’ or ‘malignant tumor’. ATEC was...
The Japanese otter lived throughout four main islands, but it has not been observed in the wild since 1979 and was declared extinct 2012. Although recent taxonomic molecular phylogenetic studies suggest that should be treated as an independent species, International Union for Conservation of Nature Red List considers subspecies Lutra lutra. Therefore, status this species needs to resolved. Here we determined complete mitochondrial genome two otters caught Kanagawa Kochi prefectures five...
BACKGROUND: Endometriosis, an estrogen-dependent disease, is believed to be influenced by multiple genetic and environmental factors. Here, we evaluated whether the risk severity of endometriosis are associated with polymorphisms in estradiol-synthesizing enzyme genes: Ser312Gly polymorphism 17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1) Arg264Cys cytochrome P450, subfamily XIX (CYP19). METHODS: All participants underwent diagnostic laparoscopy, stage was determined according Revised...