A5102888186- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Cancer Cells and Metastasis
- PARP inhibition in cancer therapy
- Advanced Breast Cancer Therapies
- Metastasis and carcinoma case studies
- Cervical Cancer and HPV Research
- Intraperitoneal and Appendiceal Malignancies
- Estrogen and related hormone effects
- Ectopic Pregnancy Diagnosis and Management
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- BRCA gene mutations in cancer
- Radiomics and Machine Learning in Medical Imaging
- Nausea and vomiting management
- Urinary and Genital Oncology Studies
- Anesthesia and Pain Management
- PI3K/AKT/mTOR signaling in cancer
- FOXO transcription factor regulation
- Colorectal and Anal Carcinomas
- MicroRNA in disease regulation
- Ultrasound and Hyperthermia Applications
- Sympathectomy and Hyperhidrosis Treatments
Osaka University of Pharmaceutical Sciences
2021-2025
Osaka Medical and Pharmaceutical University
2011-2021
The epithelial-mesenchymal-transition (EMT) is an important step in the invasion and metastasis of cancer. A critical molecular feature this process downregulation E-cadherin expression, which primarily controlled by Snail-related zinc-finger transcription factors. aim study was to evaluate prognostic impact expression EMT-related proteins (E-cadherin Snail) patients with ovarian An immunohistochemical analysis conducted using tissue microarray samples 174 primary tumors 34 metastases...
The degree of peritoneal dissemination and chemotherapy-resistant tumors is related to the prognosis in patients with advanced-stage ovarian cancer. epithelial-mesenchymal-transition (EMT) a multifaceted pathological program that endows cancer cells ability invade disseminate. CD24 frequently overexpressed various human cancers correlated poor prognosis. We herein examined functions cell lines evaluated how it contributes molecular mechanism underlying regeneration stem-like (CSCs) through...
The epithelial-mesenchymal-transition (EMT) is an important step in the invasion and metastasis of cancer. A critical molecular feature this process downregulation E-cadherin expression, which mainly controlled by Snail-related zinc-finger transcription factors (Snail Slug). aim study was to evaluate prognostic impact EMT-related protein (E-cadherin, Snail Slug) expression endometrial cancer.An immunohistochemical analysis conducted using tissue microarray samples 354 primary tumors 30...
G protein-coupled receptor 30 (GPR30) is a 7-transmembrane estrogen that functions alongside traditional receptors to regulate the cellular responses estrogen. Recent studies suggest GPR30 expression associated with poor prognosis, and this due GPR30-mediated transactivation of EGFR in breast cancer. However, biological contribution ovarian cancer remains unclear. The purpose study was elucidate relationships between clinicopathological findings, determine how signaling cascade influences...
Abstract Background Ovarian cancer (OC) is a leading cause of cancer-related death in women, and thus an accurate diagnosis the predisposition its early detection necessary. The aims this study were to determine whether serum exosomal microRNA-34a (miR-34a) ovarian could be used as potential biomarker. Methods Exosomes from OC patients’ collected, miRNAs extracted. relative expression miR-34a was calculated 58 samples by quantitative real-time polymerase chain reaction. Results Serum levels...
The rate of lymph node metastasis is extremely low in patients with low-risk endometrial cancer; lymphadenectomy may be unnecessary for these under an accurate preoperative diagnosis. aim this study was to evaluate the diagnostic accuracy myometrial invasion (MI) on magnetic resonance imaging (MRI) and intraoperative frozen sections (FSs).Endometrial cancer diagnosed a total 378 by curettage, MRI, FSs; underwent hysterectomy. depth MI evaluated between FSs, final paraffin (PSs). histologic...
(Objectives) We herein assessed the influence of Epidermal Growth Factor Receptor (EGFR) gene mutations on EGFR expression levels, downstream mediators such as Akt or ERK, and overall survival in patients with ovarian cancer. Study Design) mutation status was analyzed by direct sequencing 102 Japanese cancer patients. The expression, phosphorylated (pAkt), ERK (pERK) were determined immunohistochemistry. (Results) Twenty-nine detected 24 patinets (23.5%). observed 27.9% (19/68) serous...
This is the first report to determine feasibility and safety of total laparoscopic modified radical hysterectomy (TLMRH) in treatment presumed stage I endometrial cancer.This was a retrospective study 132 consecutive patients who underwent surgery for early cancer. Thirty-nine TLMRH bilateral salpingo-oophorectomy (BSO), 93 had abdominal extrafascial BSO. Lymphadenectomy performed 87 patients. The groups were compared epidemiological clinical characteristics, surgical outcomes, hospital...
CD24, a small heavily glycosylated mucin-like glycosyl-phosphatidylinositol-anchored cell surface protein, plays an important role in the carcinogenesis of various human malignancies. However, its function cervical cancer remains unclear. The aim present study was to evaluate expression CD24 clinicopathologically and analyze functional behavior biologically cancer. A total 117 uterine tumors were immunohistochemically analyzed using monoclonal antibody on paraffin blocks. We also examined...
Gemcitabine (2′, 2′ –difluorodeoxycytidine) is one of many nonplatinum drugs that exhibit activity in recurrent, platinum-resistant ovarian cancer. However, the molecular mechanisms by which treatment inhibits proliferation cancer cells still remain unclear. We investigated whether increases efficacy Cisplatin models vitro and vivo. used Cisplatin-resistant Caov-3 cells, A2780CP Cisplatin-sensitive A2780 to examine sensitivity cell viability using a...
Objective: There is no research regarding the appropriate antiemetic agents for female patients, especially those receiving moderately emetogenic chemotherapy (MEC).We evaluated efficacy of a combination 5-HT 3 receptor with/ without aprepitant in patients with gynecological cancer treated TC (paclitaxel and carboplatin) regimen MEC.Methods: We enrolled 38 diagnosed gynecologic scheduled to receive regimen.The were randomly assigned antagonist, either palonosetron first cycle followed by...
// Tomohito Tanaka 1, 4 , Yoshito Terai Satoe Fujiwara 1 Yoshimichi Hiroshi Sasaki Satoshi Tsunetoh Kazuhiro Yamamoto 2, 5 Takashi Yamada 3 Yoshifumi Narumi 2 and Masahide Ohmichi Department of Obstetrics Gynecology, Osaka Medical College, Takatsuki, Japan Radiology, Pathology, First Towakai Hospital, Correspondence to: Tanaka, email: gyn123@osaka-med.ac.jp Keywords: endometrial cancer; diffusion weighted image; apparent coefficient; frozen section; grade Received: February 28, 2018...
Background PD-0332991, the selective cyclin-dependent kinase 4/6 inhibitor palbociclib, causes cell cycle arrest by inhibiting phosphorylation of retinoblastoma (Rb) protein. The aim this study was to evaluate therapeutic potential PD-0332991 in endometrial cancer. Methods and findings Four human cancer lines, ECC, HEC1A, HEC108 TEN, were treated with their function evaluated. In vivo, efficacy evaluated a model subcutaneous An immunohistochemical analysis performed 337 specimens. A...
Mature cystic teratomas (MCTs) are the most common germ cell tumors of ovary. Malignant tranformation occurs in 1-2% these neoplasms. Although malignancies arising from MCTs squamous carcinomas, adenocarcinoma gastrointestinal type is extremery rare. We herein present a case intestinal MCT.A 49-year-old female underwent surgery for left ovarian tumor. The histology cyst walls revealed MCT with few hair shafts and layer, while another part tumor showed type. Five years after surgery, she...
We investigated predictors of olaparib discontinuation owing to adverse effects. Patients with ovarian, peritoneal, or fallopian tube cancers treated at Osaka Medical and Pharmaceutical University Hospital between April 2018 September 2022 were included in this study. The exclusion criteria as follows: treatment due disease progression, use anaemia medications, cytochrome P450 (CYP3A4) inhibitors. follow-up period was 90 d. Of the 46 eligible patients, 21 patients discontinued olaparib,...
Ovarian carcinosarcoma, which contains sarcomatous and carcinomatous components, is a very rare tumor. The component often adenocarcinoma, squamous cell carcinoma extremely rare. We herein report case of ovarian carcinosarcoma in the was carcinoma. A 68-year-old woman presented with huge tumor clinical diagnosis malignant ovary. She underwent hysterectomy, bilateral adnexectomy, omentectomy lymphadenectomy. Histologically, cells showed undifferentiated pleomorphic sarcoma as component. final...
Abstract Background There is uncertainty surrounding the prognostic value of peritoneal cytology in low-risk endometrial cancer, especially laparoscopic surgery. The objective this retrospective study to determine significance positive among patients with cancer and compare it between surgery conventional laparotomy. Methods From August 2008 December 2019, all cases pathologically confirmed stage IA grade 1 or 2 were reviewed at Osaka Medical College. Statistical analyses used Chi-square...
Ovarian clear cell carcinoma (OCCC) is a rare and distinct histological type of epithelial ovarian in terms its histopathological, clinical genetic features. Patients with OCCC are younger diagnosed at earlier stages than those the most common type-high-grade serous carcinoma. Endometriosis considered direct precursor OCCC. Based on preclinical data, frequent gene alternations mutations AT-rich interaction domain 1A phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha. The...