A5082276529- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Epigenetics and DNA Methylation
- Receptor Mechanisms and Signaling
- Cancer Risks and Factors
- Phosphodiesterase function and regulation
- Genetic Associations and Epidemiology
- Heart Rate Variability and Autonomic Control
- Diabetes Treatment and Management
- Peroxisome Proliferator-Activated Receptors
- Toxic Organic Pollutants Impact
- HER2/EGFR in Cancer Research
- Nutritional Studies and Diet
- Cancer Treatment and Pharmacology
- Renin-Angiotensin System Studies
- Estrogen and related hormone effects
- Protein Kinase Regulation and GTPase Signaling
- Phytoestrogen effects and research
- Effects and risks of endocrine disrupting chemicals
- Genetic Syndromes and Imprinting
Ehime University
2011-2024
Nagano Red Cross Hospital
2008-2022
Daiichi-Sankyo (Japan)
2013-2021
Tokyo Women's Medical University
2019-2021
Chuo University
2020
Tokyo Women's Medical University Yachiyo Medical Center
2019
Osaka International Cancer Institute
2019
Osaka National Hospital
2019
Sapporo National Hospital
2019
National Cancer Center Hospital East
2019
OBJECTIVE—Resistin, secreted from adipocytes, causes insulin resistance in rodents. We previously reported that the G/G genotype of a resistin gene promoter single nucleotide polymorphism (SNP) at −420 increases type 2 diabetes susceptibility by enhancing activity. report here on relation between plasma and either SNP or factors related to resistance. RESEARCH DESIGN AND METHODS—We cross-sectionally analyzed 2,078 community-dwelling Japanese subjects attending yearly medical checkup. The was...
The present study was conducted to confirm possible associations between candidate genes from genome-wide association studies and type 2 diabetes in Japanese diabetic patients a community-based general population. A total of 11 previously reported single-nucleotide polymorphisms (SNPs) the TCF7L2, CDKAL1, HHEX, IGF2BP2, CDKN2A/B, SLC30A8, KCNJ11 were analyzed.Candidate SNPs genotyped 506 402 control subjects meta-analyzed with six previous patients. Associations fasting plasma insulin levels...
Hyperglycemia is a risk factor for sarcopenia when comparing individuals with and without diabetes. However, no studies have investigated whether the findings could be extrapolated to patients diabetes relatively higher glycemic levels. Here, we aimed clarify control was associated in type 2 diabetes.Study participants consisted of (n = 746, average age 69.9 years) an older general population 2,067, 68.2 years). Sarcopenia defined as weak grip strength or slow usual gait speed low skeletal...
Glucose-6-phosphatase catalyzes the final step in gluconeogenic and glycogenolytic pathways. Glucocorticoids stimulate glucose-6-phosphatase catalytic subunit (G6Pase) gene transcription studies performed H4IIE hepatoma cells demonstrate presence of a glucocorticoid response unit (GRU) proximal G6Pase promoter. In vitro deoxyribonuclease I footprinting analyses show that receptor binds to three elements (GREs) -231 -129 promoter region transfection results indicate all contribute induction...
To characterize the clinical, autoimmune, and genetic features in Japanese adult-onset diabetic patients with GAD autoantibodies.GAD autoantibodies (GADab) were screened 4,980 age of onset >20 years hospital-based Ehime Study, GADab-positive (GADab(+)) then divided into two groups according to their insulin secretion compared nondiabetic subjects. The insulin-deficient state was defined as <0.33 nmol/l serum C-peptide (CPR) at 2 h postprandial or 6 min after a 1-mg glucagon load.GADab...
We investigated associations among intake of folate, vitamin B2, B6, B12, and polymorphisms 5,10-methylenetetrahydrofolate reductase (MTHFR) methionine synthase (MTR) genes breast cancer risk in a Japanese population. A hospital based, case-control study was conducted Nagano Prefecture, Japan, 388 pairs patients with histologically confirmed invasive age- area-matched controls selected from medical checkup examinees. Energy-adjusted intakes folate other B vitamins were derived validated food...
Global hypomethylation has been suggested to cause genomic instability and lead an increased risk of cancer. We examined the association between global methylation level peripheral blood leukocyte DNA breast cancer among Japanese women. conducted a hospital-based case–control study 384 patients aged 20–74 years with newly diagnosed, histologically confirmed invasive cancer, matched controls from medical checkup examinees in Nagano, Japan. levels were measured by LUminometric Methylation...
Background: Although impaired cardiac autonomic function is associated with an increased risk of type 2 diabetes in Caucasians, evidence Asian populations a lower body mass index limited.Methods: Between 2009–2012, the Toon Health Study recruited 1899 individuals aged 30–79 years who were not taking medication for diabetes. A 75-g oral glucose tolerance test was used to diagnose diabetes, and fasting 2-h-postload insulin concentrations measured. We assessed homeostasis model assessment...
Resistin is a novel polypeptide specifically secreted from adipocytes, and its serum levels are increased in obese diabetic mice. antagonizes insulin could account for resistance. To determine whether there single nucleotide polymorphisms (SNPs) the resistin gene associated with type 2 diabetes, sequences 24 Japanese patients were initially analyzed using PCR direct sequencing. Three SNPs found introns, but none present coding regions. The allele frequencies of genomic −167C&gt;T,...
To clarify heterogeneity in Japanese adult-onset type 1 diabetes, we analyzed the HLA-DR and -DQ haplotypes, depending on clinical phenotype, compared them with those childhood-onset diabetes (CO). The patients a previously reported Ehime Study were divided into subgroups by mode of onset diabetes: 68 acute-onset diabetic (AO) 28 slowly progressive (SO). HLA haplotypes 80 CO 190 control subjects. Two major susceptible Japanese, DRB1*0405-DQB1*0401 (DR4) DRB1*0901-DQB1*0303 (DR9),...
Insulin inhibits transcription of the genes encoding glucose-6-phosphatase catalytic subunit (G6Pase), phosphoenolpyruvate carboxykinase, and IGF binding protein-1 through insulin response sequences (IRSs) that share same core sequence, T(G/A)TTTT(G/T). The factors FOXO1a FOXO3a have been shown to bind these elements, but there are conflicting reports as whether this correlates with action on gene transcription. Some researchers concluded, from overexpression experiments using FOXO1a,...
Variants in the CDH13 gene have been identified as determinants of blood levels adiponectin, an insulin-sensitizing adipokine. However, their association with other metabolic risk factors remains unclear. We examined variants at relation to total and high-molecular-weight (HMW) adiponectin using data from a genome-wide study performed 2,434 Singaporean Chinese replication up 3,290 Japanese 1,610 Koreans. The top signal rs4783244 showed strong associations (standardized β [β] = -0.34, 95% CI...
The Japanese Society of Nuclear Medicine has recently published the consensus guidelines for pediatric nuclear medicine. This article is English version guidelines. Part 1 proposes dose optimization in medicine studies. 2 comprehensively discusses imaging techniques appropriate conduct procedures, considering characteristics children.
Insulin resistance is a feature of type 2 diabetes. Resistin, secreted from adipocytes, causes insulin in mice. We previously reported that the G/G genotype single nucleotide polymorphism (SNP) at -420 (rs1862513) human resistin gene (RETN) increased susceptibility to diabetes by enhancing its promoter activity. Plasma was highest Japanese subjects with genotype, followed C/G, and C/C. In this study, we cross-sectionally analyzed plasma SNPs RETN region 2,019 community-dwelling subjects....
Global hypomethylation of leukocyte DNA has been associated with an increased risk cancer. As dietary and genetic factors related to one-carbon metabolism may influence both the methylation synthesis DNA, we investigated associations between these global level peripheral blood based on a cross-sectional study 384 Japanese women. Dietary intake folate vitamins B2, B6, B12 was assessed validated semiquantitative food frequency questionnaire. Five polymorphisms in methylenetetrahydrofolate...
Although many in vitro and animal studies have suggested a protective effect of green tea against breast cancer, only few epidemiological examined this association, findings been inconsistent. We the association between consumption cancer risk consideration hormone receptor status tumors investigated whether was modified by dietary genetic factors based on hospital-based case-control study Nagano, Japan. A total 369 pairs completed validated food frequency questionnaire provided blood...