A5035606493- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Health and Disease Prevention
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Gout, Hyperuricemia, Uric Acid
- Alcohol Consumption and Health Effects
- Cardiovascular Disease and Adiposity
- Nutritional Studies and Diet
- Adipose Tissue and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Regulation of Appetite and Obesity
- Chronic Kidney Disease and Diabetes
- Neonatal Health and Biochemistry
- Genetic Associations and Epidemiology
- Cerebrovascular and Carotid Artery Diseases
- Dialysis and Renal Disease Management
- Diet, Metabolism, and Disease
- Inflammatory Biomarkers in Disease Prognosis
- Lipoproteins and Cardiovascular Health
- Nutrition and Health in Aging
- Folate and B Vitamins Research
- Epigenetics and DNA Methylation
- Heart Rate Variability and Autonomic Control
- Apelin-related biomedical research
Kawamura Hospital
2014-2025
Ehime University
2016-2025
Osaka University
2025
Osaka Metropolitan University
2024
Ehime Medical Center
2011
Yokohama City University Medical Center
2010
Shiga University of Medical Science
2010
Yokohama City University
2010
Ehime Prefectural Central Hospital
1988
The present study was conducted to confirm possible associations between candidate genes from genome-wide association studies and type 2 diabetes in Japanese diabetic patients a community-based general population. A total of 11 previously reported single-nucleotide polymorphisms (SNPs) the TCF7L2, CDKAL1, HHEX, IGF2BP2, CDKN2A/B, SLC30A8, KCNJ11 were analyzed.Candidate SNPs genotyped 506 402 control subjects meta-analyzed with six previous patients. Associations fasting plasma insulin levels...
Hypertension is one of the most common complex genetic disorders. We have described previously 38 single nucleotide polymorphisms (SNPs) with suggestive association hypertension in Japanese individuals. In this study we extend our previous findings by analyzing a large sample individuals (n=14 105) for associated SNPs. also conducted replication analyses susceptibility loci identified recently from genome-wide studies European ancestries. Association analysis revealed significant ATP2B1...
The aim of the present study was to examine how liver markers are associated with insulin resistance in Japanese community-dwelling adults. This cross-sectional included 587 men aged 58 ± 14 (mean standard deviation; range, 20–89) years and 755 women 60 12 (range, 21–88) years. sample consisted 998 (74.4%) non-obese [body mass index (BMI) <25.0 kg/m2] 344 (25.6%) overweight (BMI ≥25 kg/m2) subjects. Insulin defined by homeostasis model assessment (HOMA-IR) at least 2.5, HOMA-IR potential...
There are few studies to demonstrate the associations between newly addressed lipid profiles and metabolic syndrome (MetS)-associated variables.Study participants without medications for hypertension, diabetes, or dyslipidemia {614 men aged 58 ± 14 (mean standard deviation; range, 20-89) years 779 women 60 12 (range, 21-88) years} were randomly recruited from a single community at time of their annual health examination. The association (total cholesterol (T-C), triglycerides (TG),...
Objective Carotid intima-media thickness (IMT) is a useful surrogate marker of cardiovascular disease. In addition to low-density lipoprotein cholesterol (LDL-C), metabolic syndrome has been linked the pathogenesis atherosclerosis. The present study investigated whether clustering multiple components greater impact on vascular parameters than individual syndrome, and assessed association between carotid IMT LDL-C syndrome.Methods was evaluated B-mode ultrasonography in 760 patients (340 men...
Variants in the CDH13 gene have been identified as determinants of blood levels adiponectin, an insulin-sensitizing adipokine. However, their association with other metabolic risk factors remains unclear. We examined variants at relation to total and high-molecular-weight (HMW) adiponectin using data from a genome-wide study performed 2,434 Singaporean Chinese replication up 3,290 Japanese 1,610 Koreans. The top signal rs4783244 showed strong associations (standardized β [β] = -0.34, 95% CI...
The correlation between serum uric acid/creatinine (SUA/Cr) ratio and hypertension risk has not been well studied. This study aims to examine whether the SUA/Cr is a predictor of hypertension. cohort comprised 171 men aged 64 ± 11 (mean standard deviation) years 266 women 65 10 recruited for survey at community-based annual medical check-up. main outcome was presence (antihypertensive medication) having systolic blood pressure (SBP) ≥ 140 mmHg diastolic (DBP) 90 mmHg. baseline significantly...
Abstract Background Decreased levels of high‐molecular‐weight (HMW) adiponectin are associated with metabolic syndrome and insulin resistance. This relationship may be further confounded by alcohol consumption, which plays a role in the development liver dysfunction. In Japan, few studies have investigated between HMW consumption mortality. Methods The study included 845 male participants (mean age, 61 ± 13 years; range, 20–89 years) 1065 female 63 11 22–88 years). Of participants, 809...
Aim: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities and predictor both type 2 diabetes mellitus adverse cardiovascular events. Whether there are gender differences in the association between early atherosclerosis MetS has not yet been thoroughly elucidated.Methods: The subjects consisted 388 men aged 64±16 years 480 women 70±13 years. Early was assessed by carotid intima-media thickness (IMT) on B-mode ultrasonography.Results: Carotid IMT values were significantly greater...
Chronic kidney disease (CKD) is a major public health problem, but there controversy over whether or not CKD an independent risk factor for peripheral arterial stiffness in community residents.We randomly recruited 107 men, aged 68+/-9 (mean +/- standard deviation) years, and 203 women, 67+/-7 years during their annual examination single community. Study subjects did have clinical history of cerebrovascular current neurological abnormalities. Peripheral was evaluated by mean pulse wave...
In Western countries, one of the most important modifiable targets for prevention cardiovascular diseases is metabolic syndrome. Adiponectin an adipose tissue-specific plasma protein that inversely associates with Among several molecular isoforms, high-molecular-weight (HMW) complex considered active form. Increased serum high-sensitivity C-reactive (hsCRP) concentration also syndrome, and adiponectin could modulate levels. Here, through cross-sectional investigation, we investigated whether...
Pulse wave velocity (PWV) is a simple and noninvasive method of measuring arterial stiffness for the assessment cardiovascular disease in high-risk populations. This association may be further confounded by hemoglobin status, which involved development atherosclerosis. We randomly recruited 120 men 223 women aged 69 ± 9 68 7 years, respectively, during their annual health examination single community. Arterial was evaluated brachial–ankle PWV (baPWV). The value baPWV different from women. In...
Insulin resistance is a feature of type 2 diabetes. Resistin, secreted from adipocytes, causes insulin in mice. We previously reported that the G/G genotype single nucleotide polymorphism (SNP) at -420 (rs1862513) human resistin gene (RETN) increased susceptibility to diabetes by enhancing its promoter activity. Plasma was highest Japanese subjects with genotype, followed C/G, and C/C. In this study, we cross-sectionally analyzed plasma SNPs RETN region 2,019 community-dwelling subjects....
Abstract Background Low-density lipoprotein cholesterol (LDL-C) independently impacts aging-related health outcomes and plays a critical role in cardiovascular diseases (CVDs). However, there are limited predictive data on all-cause mortality, especially for the Japanese community population. In this study, it was examined whether LDL-C is related to survival prognosis based 7 or 10 years of follow-up. Methods Participants included 1610 men (63 ± 14 old) 2074 women (65 12 who participated...
High-sensitivity C-reactive protein (hsCRP) is a sensitive marker of inflammation. This study aimed to determine whether increased hsCRP levels are associated with all-cause mortality rate.
Aspiring to become a physician is natural expectation for applicants medical school. However, choosing career in medicine critical decision, especially countries where high school students can apply without an undergraduate degree. Students may select various reasons, including parental pressure and academic performance. The question of whether there are who enroll clear intentions becoming doctors has not been extensively investigated the literature. We conducted retrospective study at...
Chronic kidney disease (CKD) is a major public health problem. There conflicting evidence concerning whether CKD an independent risk factor for carotid intima-media thickness (IMT).The study subjects were 428 men aged 70+/-15 (mean+/-standard deviation) years and 582 women 75+/-12 enrolled consecutively from patients in the Medical Department of Seiyo Municipal Nomura Hospital. Carotid IMT was derived via B-mode ultrasonography evaluated by estimated glomerular filtration rate (eGFR) using...
Metabolic syndrome (MetS) is associated with an increased risk of major cardiovascular events. Increased high-sensitivity C-reactive protein (hsCRP) levels are MetS and its components. Changes in gamma-glutamyl transferase (GGT) response to oxidative stress also MetS, the could be modulated by hsCRP. From a single community, we recruited 822 men (mean age, 61 ± 14 years) 1,097 women (63 12 during their annual health examination. We investigated whether hsCRP GGT synergistically insulin...
There are few data focusing on the effect of insulin resistance a new risk category prehypertension (120-139 mmHg systolic and/or 80-89 diastolic blood pressure) recently established by The Seventh Report Joint National Committee High Blood Pressure (JNC-7). We aimed to determine whether was associated with for and hypertension.Of 3,164 (34.6% 9,133 adults aged 19 90 years) at community-based annual medical check-up, study participants without clinical history stroke, transient ischemic...