A5005133704- Effects and risks of endocrine disrupting chemicals
- Hippo pathway signaling and YAP/TAZ
- Advanced Photocatalysis Techniques
- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- RNA modifications and cancer
- Heavy Metal Exposure and Toxicity
- Electrocatalysts for Energy Conversion
- Air Quality Monitoring and Forecasting
- Perovskite Materials and Applications
- Photochromic and Fluorescence Chemistry
- Pharmacological Effects of Natural Compounds
- Cancer-related molecular mechanisms research
- Advanced Battery Technologies Research
- Immune Cell Function and Interaction
- Autonomous Vehicle Technology and Safety
- Gut microbiota and health
- Functional Brain Connectivity Studies
- Immune cells in cancer
- Electric and Hybrid Vehicle Technologies
- RNA Research and Splicing
- Plant Molecular Biology Research
- Vehicle Dynamics and Control Systems
- Traditional Chinese Medicine Analysis
- Advanced Battery Materials and Technologies
Shenyang Medical College
2016-2025
Fudan University
2020-2025
Xinjiang Medical University
2025
First Affiliated Hospital of Xi'an Jiaotong University
2014-2025
Xian Central Hospital
2014-2025
Hainan University
2024-2025
Northwest University
2025
China Institute of Water Resources and Hydropower Research
2025
Harvard University
2024-2025
Wenzhou Medical University
2025
The aim of this study was to evaluate the levels semi-volatile compounds (SVOCs) in residential detached houses Sapporo, Japan, and whether exposure these SVOCs associated with development building-related symptoms named 'sick house syndrome' (SHS). definition SHS is fundamentally same as that sick building syndrome (SBS). presence evaluated using a validated self-administered questionnaire. Surveys samplings air dust 41 dwellings were performed from October 2006 January 2007, 134 occupants...
Abstract Designing definite metal‐support interfacial bond is an effective strategy for optimizing the intrinsic activity of noble metals, but rather challenging. Herein, a series quantum‐sized metal nanoparticles (NPs) anchored on nickel metal–organic framework nanohybrids (M@Ni‐MOF, M=Ru, Ir, Pd) are rationally developed through spontaneous redox strategy. The metal‐oxygen bonds between NPs and Ni‐MOF guarantee structural stability sufficient exposure surface active sites. More...
Mutations in the neurofibromatosis type 2 (NF2) gene that limit or abrogate expression of functional Merlin are common malignant mesothelioma. activates Hippo pathway to suppress nuclear translocation YAP and TAZ, major effectors associate with TEAD transcription factors nucleus promote genes involved cell proliferation survival. In this article, we describe discovery compounds selectively inhibit YAP/TAZ-TEAD promoted transcription, block auto-palmitoylation, disrupt interaction between...
An IR-driven photocatalytic water splitting system based on WO2–NaxWO3 (x > 0.25) hybrid conductor materials was established for the first time; this can be directly applied in seawater. The material readily prepared by a high-temperature reduction process of semiconductor NaxWO3 < nanowire bundles. A novel ladder-type carrier transfer is suggested system.
Abstract Modulating the microenvironment of single‐atom catalysts (SACs) is critical to optimizing catalytic activity. Herein, we innovatively propose a strategy improve local reaction environment Ru single atoms by precisely switching crystallinity support from high crystalline and low crystalline, which significantly improves hydrogen evolution (HER) The catalyst anchored on low‐crystalline nickel hydroxide (Ru−LC−Ni(OH) 2 ) reconstructs distribution balance interfacial ions due activation...
Abstract Designing definite metal‐support interfacial bond is an effective strategy for optimizing the intrinsic activity of noble metals, but rather challenging. Herein, a series quantum‐sized metal nanoparticles (NPs) anchored on nickel metal–organic framework nanohybrids (M@Ni‐MOF, M=Ru, Ir, Pd) are rationally developed through spontaneous redox strategy. The metal‐oxygen bonds between NPs and Ni‐MOF guarantee structural stability sufficient exposure surface active sites. More...
We evaluated the effects of inhaled di(2-ethylhexyl)phthalate (DEHP) on onset puberty and postpubertal reproductive functions in prepubertal female rats. DEHP was administered by inhalation at doses 0, 5, 25 mg/m3 to groups rats for 6 h/day, 5 contiguous days/week from postnatal days (PNDs) 22 41 PND 84. The determined daily examination vaginal opening (VO) first estrous cycle. Reproductive function observing cyclicity PNDs 49 Upon completion exposure, were sacrificed 42 85–88 during...
Sertraline, one of the oldest antidepressants, remains to be most efficacious treatment for depression. However, major depression disorder (MDD) is characterized by altered emotion processing and deficits in cognitive control. In interference tasks, patients with MDD have shown excessive hypothalamus activity. The purpose this study was examine effects antidepressant (sertraline) on hypothalamus-anchored resting brain circuitry. Functional magnetic resonance imaging conducted depressed...
The rational design of carbonaceous hybrid nanostructures is very important for obtaining high photoactivity. TiO2 particles strewn with an optimal quantity carbon nanodots have a much higher photoactivity than that covered layer, showing the importance morphology in photocatalysis nanostructures.
Due to inevitable parameter uncertainties and disturbances, four-wheel independent drive automated vehicles (4WIDAVs) will produce tracking deviation during the path following process, which have a negative impact on driving safety. Meanwhile, over-actuated feature of 4WIDAVs also increase if not properly handled. To solve this problem, specific adaptive model predictive control strategy for is proposed. Firstly, obtain real-time accurate vehicle dynamics model, recursive least square method...
Bisphenol A (BPA) is a widespread endocrine disruptor that induces the impairment of immune cells, but mechanism remains unknown. Macrophages are one most important cells in innate and adaptive immunity. In this study, we aimed to probe effects BPA on damage RAW264.7 its mechanisms action, especially focusing relationship between autophagy apoptosis. Cells were pretreated with 10 mg/L LPS, or added activator RAPA, inhibitor 3-MA Bcl-2 ABT-737, then treated (0, 10, 100 200 μmol/L) for 12 h....
Abstract Na metal has shown great promise as anode material for Na‐based batteries due to its high theoretical capacity, low potential, abundance, and cost. However, the uneven solid electrolyte interphase layer formed on surface caused by side reactions with serious corrosion will lead dendrite formation safety issues. Here we report a stable coating Bi layer, which is in situ through simple ion‐exchange. The compact can effectively prevent reacting suppress of dendrites. Na/Bi exhibits...
Photorespiratory hydrogen peroxide (H2 O2 ) plays key roles in pathogenesis responses by triggering the salicylic acid (SA) pathway Arabidopsis. However, factors linking intracellular H2 to activation of SA remain elusive. In this work, catalase-deficient Arabidopsis mutant, cat2, was exploited elucidate impact S-nitrosoglutathione reductase 1 (GSNOR1) on -dependent signalling pathways. Introducing gsnor1-3 mutation into cat2 background increased S-nitrosothiol levels and abolished...
Germline alterations of the NF2 gene cause neurofibromatosis type 2, a syndrome manifested with benign tumors, and Nf2 deletion in mice also results slow tumorigenesis. As regulator Hippo signaling pathway, induces LATS1/2 kinases consequently represses YAP/TAZ. YAP/TAZ oncoproteins are inhibited by motin family proteins (Motins). Here, we show that is fine-tuned Motins NF2-dependent manner, which recruits E3 ligase RNF146 to facilitate ubiquitination subsequent degradation Motins. In...
A recruiting rate (krc) of 0.1–5 s–1 has been proposed as the criterion for super-resolution spontaneously blinking rhodamines. Accurate prediction rhodamines is very important developing However, far we know, there no reliable theoretical method to predict krc. Herein, meticulously investigated effect intermolecular hydrogen bonds on spirocyclization reactions Moreover, a descriptor (ΔEC–T) was reliably assess ΔEC–T quantified ring-opening energy barrier reactions. robust linear correlation...
<title>Abstract</title> <bold>Objectives: </bold>This study aimed to: (1) Rigorously validate the Chinese PrAS-S psychometrically; (2) Precisely determine pregnancy-related anxiety prevalence and severity among pregnant women; (3) Scrutinize its significant influencing factors. <bold>Background:</bold> Given anxiety’s importance for maternal mental health, we used a cross-sectional of 300 Urumqi women. We to evaluate levels, analyze status factors, support clinical psychological nursing....