Abstract Purpose: We previously reported the usefulness of a qualified highly sensitive detection method for human telomerase reverse transcriptase (hTERT) mRNA in serum with 89.7% sensitivity hepatocellular carcinoma (HCC). In this study, we developed quantitative hTERT and examined clinical significance HCC diagnosis. Experimental Background: 64 patients HCC, 20 liver cirrhosis, chronic hepatitis, 50 healthy individuals, measured by using newly real-time transcription-PCR SYBR Green I. its...

Abstract Background Cartilage conduction hearing aids (CCHAs) were newly devised and spread fast in Japan since their launch 2017. However, little knowledge is available for this new device. Purpose The aim of study was to establish the CCHAs suggest indication. Research Design Correlational study. Study Sample A total 256 patients registered. Data Collection Analysis fitting surveyed nine institutions. outcomes assessed by audiometric tests. classified into seven groups, depending on ear...

To investigate the usefulness of magnetic resonance imaging (MRI) including three-dimensional (3D) sequences in differentiation between Bell's palsy (BP) and Ramsay Hunt syndrome (RHS).A prospective study.Tertiary care center.Twenty patients: 15 patients with BP five RHS.Diagnostic.Clinical diagnosis (BP or RHS).The presence hyperintensity on 3D-fluid-attenuated inversion recovery sequence (3D-FLAIR) enhancement gadolinium-enhanced (CE)-3D-FLAIR CE-3D-T1-weighted image (3D-T1WI) along...

Abstract Background Innovated hearing aids (HAs), termed cartilage conduction (CC-HAs), show good performance in patients with closed ears and continuous otorrhea. However, factors other than the ear condition that influence purchase rate of CC-HAs remain unclear. Purpose To identify CC-HAs. Research Design A correlational study. Study Sample total 249 were enrolled. Data Collection Analysis The patients' demographics, clinical characteristics, outcomes, CC-HA transducer types compared. data...

Objective Glucosylceramide (Glu‐Cer), a glycosylated form of ceramide, has been reported to have cytotoxic effects in the cells various cancers. We previously that dietary Glu‐Cer from rice bran had inhibitory on human head and neck squamous cell carcinoma (HNSCC) nonobese diabetes (NOD)/severe combined immunodeficiency (SCID) mice. In HNSCC, preventing recurrence second primary cancer is required improve prognosis. The purpose present study was determine whether anticarcinogenic...

Numerous studies have reported sound-induced motion of the tympanic membrane (TM). To demonstrate sequential characteristics entire TM by noncontact laser Doppler vibrometry (LDV), we investigated multipoint measurement.A vibrometer was mounted on a surgical microscope. The velocity measured at 33 points using LDV without any reflectors. Measurements were performed with tonal stimuli 1, 3, and 6 kHz. Amplitudes calculated from these measurements, time-dependent changes in described graphics...

Objective: In order to help a surgeon make the best decision, more objective method of measuring ossicular motion is required.Methods: A laser Doppler vibrometer was mounted on surgical microscope. To measure chain vibrations, eight patients with cochlear implants were investigated. assess motions chain, velocities at five points measured tonal stimuli 1 and 3 kHz, which yielded reproducible results. The sequential amplitude change each point calculated phase shifting from stimulus. Motion...

The cartilage-conduction pathway was recently proposed as a third auditory pathway; however, middle-ear vibrations have not yet been investigated in vivo. We aimed to measure the ossicles and bone vibration upon stimulation with non-contact laser Doppler vibrometer. recruited adult patients normal ear structures who underwent cochlear implant surgery at our hospital between April 2020 December 2022. For sound input, transducer, custom-made by RION Corporation (Tokyo, Japan), fixed surface of...

Gorham-Stout disease, a rare and intractable disease of unknown etiology, causes systemic bone lysis replacement with lymphoid tissue. Here, we report case cerebrospinal fluid leakage in 16-year-old boy. The patient complained nasal discharge, right ear obstruction, fever, headache. A computed tomography scan the head showed osteolysis around internal carotid artery, vestibule, cochlea osteolytic changes left parietal bone. It was suggested that had bacterial meningitis owing to from fistula...

Anaplastic thyroid carcinoma (ATC) is an aggressive type of cancer, and its metastasis requires cell motility. Ceramide involved in a variety biological processes, including inflammation, signaling, motility, induction apoptosis, however has not previously been reported to inhibit the motility ATC cells. We evaluated effect short chain C6-ceramide on cells.Cell 8305C line treated with was assessed using transwell migration assay pseudopodia formation assay.Treatment 10 µM resulted...

A 75-year-old female patient presented with a suspected recurrence of clival chordoma. The tumor was resected using the infratemporal fossa type B and anterior petrosal approach help neurosurgeon. During cauterization trigeminal nerve, developed cardiac arrest for approximately 10 seconds because trigemino-cardiac reflex (TCR). After several sternal compressions, there return spontaneous circulation. operation resumed after circulatory dynamics stabilized. Subsequently, surgery completed...

Postoperative hearing results of type IV tympanoplasty have been shown to poorer than other reconstruction techniques. There are numerous reports evaluating the factors for improvement. This preliminary study aimed analyze and determine that affect results.A total 80 patients who underwent were evaluated participate in this study. The medical records candidate collected retrospectively. Fifty out recruited excluded due following reasons: they could not be followed-up more a year after final...

Superficial siderosis is a disease in which iron from hemoglobin deposited the central nervous system, resulting conditions such as progressive sensorineural hearing loss, cerebellar ataxia, dementia, and pyramidal signs. A 30-year-old man with superficial received cochlear implant left ear, had shown complete loss. Good auditory responses were obtained at 14 days after implantation. The postoperative average level was 56.7 dB 3 months 55.0 6 months. However, patient showed gradual dynamic...

Objective Few reports discuss the characteristics of repeated recidivism cholesteatoma. We describe clinical patients with cholesteatoma who experienced at least two episodes after initial surgery for requiring canal wall reconstruction. Methods reviewed medical records 11 underwent reconstruction our department between April 2008 and March 2018 subsequently relapses that necessitated revision involving tympanomastoidectomy Patient age time first ranged from 6 to 56 (mean, 25.7) years. Seven...

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Vibration of human tympanic membrane induced by sound is transmitted to a cochlea via auditory ossicles and stimulates an nerve. Therefore, detailed study the vibration necessary elucidate mechanisms hearing. In present study, sound-induced analyzed numerically means multibody dynamics. Numerical model created precisely using pictures computerized axial tomography scan. Vibrational responses force are calculated with stimuli from 1 10 kHz.

The vibration of human tympanic membrane induced by sound is transmitted to a cochlea via auditory ossicles and stimulates an nerve. Therefore, the detailed study necessary elucidate mechanisms hearing. In present study, sound-induced was measured using laser doppler vibrometer optical system surgical microscope in three volunteers. Measurements were performed with stimuli 1 3 kHz at 100 dB SPL. examinees vibrated same frequency as that applied pressure. Malleus Incus rotational motion one...

An abstract is not available for this content. As you have access to content, full HTML content provided on page. A PDF of also in through the ‘Save PDF’ action button.

The vibration of human tympanic membrane induced by sound is transmitted to a cochlea via auditory ossicles and stimulates an nerve. Therefore, the detailed study motion necessary elucidate mechanisms hearing. In present study, sound-induced was measured using laser doppler vibrometer surgical microscope in subject at two frequencies. center stapes ossicles. Experimental results show that vibrate with frequency amplitude smaller than membrane. This important because it provides crucial...

耳鼻咽喉科・頭頸部外科医が，気管癌に遭遇する機会は殆んどない。その初発症状は，気管狭窄，喘鳴，血痰などであり，他科において気管支炎や気管支喘息として診断や治療を受けることが多い。このために診断が遅れ，不幸な転帰をとることも少なくない。今回，われわれは，健康診断で発見された，気管腺様嚢胞癌の症例を経験したので報告する。症例は39歳女性，胸部の異常陰影を指摘され，某大学病院呼吸器外科に紹介された。胸部CTにおいて，前縦隔と右頸部に結節状の陰影を認めた。さらに穿刺吸引細胞診検査により，前縦隔の腫瘤は胸腺腫，右頸部の腫瘤は腺様嚢胞癌と診断された。気管支鏡検査においても，声門直下から第7気管輪にいたる間に，腫瘍の浸潤が確認された。同部位からの生検でも，腺様嚢胞癌と診断された。また，PET/CT検査では，前縦隔と甲状腺右葉の背側に，FDGの集積を認めた。MRIでは，気管の右外側壁から，気管の内外に浸潤する腫瘍を認めた。この腫瘍に対する治癒切除術に際して，アプローチは気管支鏡で腫瘍を認めなかった第7気管輪の下方より開始したが，切除断端は陽性であった。切除マージンは迅速病理を繰り返して決定したが...

It is extremely rare to develop metastasis of differentiated thyroid carcinoma the axillary lymph nodes, non-regional nodes. The likely lymphogenous because patients showing only in axilla without other distant metastasis. Four 924 with who underwent curative resection our institution and Kyoto Medical Center showed (0.43%) during follow-up until July, 2008 from April, 1981. were aged 61-73 years old, 2 well-differentiated poorly-differentiated papillary carcinoma, 1 male 3 female, already...