A5023561910- Ear Surgery and Otitis Media
- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Ear and Head Tumors
- Surgical Simulation and Training
- Bone Tumor Diagnosis and Treatments
- Head and Neck Surgical Oncology
- Neuroscience and Neuropharmacology Research
- Meningioma and schwannoma management
- Soft Robotics and Applications
- Augmented Reality Applications
- Noise Effects and Management
- Dental Radiography and Imaging
- Speech and Audio Processing
- Indoor and Outdoor Localization Technologies
- Oral and Maxillofacial Pathology
- Spinal Fractures and Fixation Techniques
- Facial Nerve Paralysis Treatment and Research
- Ion channel regulation and function
- Craniofacial Disorders and Treatments
- Subtitles and Audiovisual Media
- Dysphagia Assessment and Management
- Assistive Technology in Communication and Mobility
- Photoreceptor and optogenetics research
Kyushu University
2015-2025
Kyushu University Hospital
2022
University of Fukui
2020-2022
Onomichi General Hospital
2020-2022
Mita Hospital
2019
Kindai University
2015
Kindai University Sakai Hospital
2015
House Clinic
2005-2010
The ganglioside GM3 synthase (SAT-I), encoded by a single-copy gene, is primary glycosyltransferase for the synthesis of complex gangliosides. In SAT-I null mice, hearing ability, assessed brainstem auditory-evoked potentials (BAEP), was impaired at onset and had been completely lost 17 days after birth (P17), showing deformity in hair cells organ Corti. By 2 months age, Corti selectively disappeared without effect on balance or motor function histology vestibule. Interestingly,...
Abstract Brain‐type fatty acid‐binding protein (B‐FABP) belongs to a family of intracellular lipid‐binding proteins. B‐FABP exhibits binding affinity long‐chain acids (FAs) whose effects on brain functions including development, emotion, learning and memory have been proposed. is localized in the ventricular germinal cells embryonic astrocytes developing mature rodents. In present study we generated mouse harboring null mutation gene studied its phenotype. mutant mice exhibited enhanced...
1 Nystatin-perforated patch recordings were made from mechanically dissociated basolateral amygdala neurons with preserved intact native presynaptic nerve terminals to study the mechanism of 5-HT3 receptor-mediated serotonergic modulation GABAergic inhibition. 2 The specific agonist mCPBG (1 μM) rapidly facilitated frequency miniature inhibitory postsynaptic currents (mIPSCs) and this facilitation desensitized within min. Tropisetron (30 nM), a antagonist, blocked effect. 3 augmented mIPSC...
<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> An image-guided surgical system for otologic surgery was developed and clinically evaluated. With reliable hybrid registration, real-time patient movement compensation virtual intraoperative computed tomography imaging have been originally proposed. In contrast to the commercially available systems that mainly use 2-D images pointing probes, in this system, drill position is navigated displayed...
Objectives/Hypothesis Image‐guided optical tracking systems are being used with increased frequency in lateral skull base surgery. Recently, electromagnetic have become available for use this region. However, the clinical accuracy of system has not been examined This study evaluates navigation Study Design Cadaveric and radiographic study. Methods Twenty cadaveric temporal bones were dissected a surgical setting under commercially available, system. The target registration error (TRE) was...
Objectives/Hypothesis The extreme rarity of temporal bone squamous cell carcinoma (TB‐SCC) has delayed the accumulation high‐quality clinical evidence. For purposes retrospective meta‐analysis in future, a large dataset with information from various institutions would be ideal. Our objective here was to retrospectively review cases TB‐SCC encountered at single tertiary referral center and explore survival outcomes prognostic factors. Study Design Retrospective chart review. Methods medical...
OBJECTIVE A new, minimally invasive registration method was developed for image‐guided otologic surgery. We utilized laser‐sintered template of the patient's bone surface to transfer virtual markers intraoperatively and eliminated necessity preoperative marker positioning or additional CT scan. STUDY DESIGN Simulation surgeries clinical application. SUBJECTS AND METHODS measured errors in 10 trials using replicas six ear (two cochlear implant insertions, four translabyrinthine acoustic tumor...
Objective We recently developed a new noninvasive registration method for image-guided otologic surgery (STAMP method). investigated the benefit and potential drawback of our in clinical application tested feasibility routine surgery. Study Design Retrospective case review. Setting Tertiary referral university hospital. Patients Forty-six cases (45 patients) that underwent cochlear implantation Kyushu University Hospital during period 2007 2010 were informed option to use navigated...
Peristomal wound infections are common complications of percutaneous endoscopic gastrostomy (PEG). The Funada-style gastropexy device has two parallel needles with a wire loop and suture thread, was developed about 20 years ago in Japan. This kit allowed us to perform dual very easily; PEG become popular technique present study aimed compare the advantages disadvantages standard 'pull' method.We retrospectively reviewed 182 consecutive, non-randomized patients undergoing our hospital,...
Conclusion: The surface template-assisted marker positioning (STAMP) method is useful for successful Bonebridge™ (BB) implantation on a planned site while avoiding dangerous positions. Objectives: To confirm the usefulness of STAMP safe operation BB. Methods: From patient's temporal bone CT data, guide plate and confirmation were generated by method. used to mark correct place implantation, lets us know angle depth hole. Results: With plate, BB was easily found. hole made be an appropriate...
Williams syndrome (a.k.a. Williams-Beuren Syndrome) is a multisystem disorder caused by the hemizygous deletion of 1.6 Mb region at 7q11.23 encompassing about 26 genes, including that encoding LIM kinase 1 (LIMK1). Individuals with Syndrome manifest hyperacusis and progressive hearing loss, early onset suggests it could be associated one deleted genes. Based on our results critical role kinases in regulation motile responses cochlear outer hair cells (OHC) amplification, we propose here...
To obtain new insights into research questions on how executive function and social interaction would be observed to change after the introduction of hearing aids (HAs) in older people with impairment.Multi-institutional prospective single-arm observational study.Outpatients complaints difficulty who visited HA clinics between October 18, 2017, June 30, 2019, 7 different university hospitals Japan.The inclusion criteria study named Hearing-Aid Introduction for Hearing-Impaired Seniors...
Abstract Background Cartilage conduction hearing aids (CCHAs) were newly devised and spread fast in Japan since their launch 2017. However, little knowledge is available for this new device. Purpose The aim of study was to establish the CCHAs suggest indication. Research Design Correlational study. Study Sample A total 256 patients registered. Data Collection Analysis fitting surveyed nine institutions. outcomes assessed by audiometric tests. classified into seven groups, depending on ear...
Presynaptic and postsynaptic membrane activities during experimental metabolic inhibition were analysed in mechanically dissociated rat hippocampal neurons using nystatin‐perforated conventional whole‐cell patch clamp recordings. NaCN, an inhibitor of mitochondrial ATP synthesis, induced outward current across the soma membrane. This was blocked by tolbutamide, a sulfonylurea, which blocks ATP‐sensitive K + (K ) channels. The presynaptic effect inhibitors such as NaN 3 , or glucose‐free...